Cyclin D1 as a therapeutic target of renal cell carcinoma- a combined transcriptomics, tissue microarray and molecular docking study from the Kingdom of Saudi Arabia.

abstract：BACKGROUND:The apoptosis inhibitor-5 (API5), anti-apoptosis protein, is considered a key molecule in the tumor progression and malignant phenotype of tumor cells. Here, we investigated API5 expression in cervical cancer, its clinical significance, and its relationship with phosphorylated extracellular signal-regulated ...

journal_title：BMC cancer

authors： Cho H,Chung JY,Song KH,Noh KH,Kim BW,Chung EJ,Ylaya K,Kim JH,Kim TW,Hewitt SM,Kim JH

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:Despite the excellent results obtained with hormone therapy, the long treatment period and the side effects associated with its use make patient adherence difficult. Moreover, certain aspects of health care can mitigate or exacerbate non-adherence. This study aimed to identify the factors associated with adh...

journal_title：BMC cancer

authors： Brito C,Portela MC,de Vasconcellos MT

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:Cancer is an extremely heterogeneous group of diseases traditionally categorized according to tissue of origin. However, even among patients with the same cancer subtype the cellular alterations at the molecular level are often very different. Several new therapies targeting specific molecular changes found ...

journal_title：BMC cancer

authors： Kristensen LS,Kjeldsen TE,Hager H,Hansen LL

更新日期：2012-11-23 00:00:00

abstract：BACKGROUND:Breast cancer is the most common malignancy in women world-wide. Triple negative breast cancer (TNBC) is a highly aggressive subtype that lacks expression of hormone receptors for estrogen, progesterone and human epidermal growth factor 2; and is associated with a high propensity for metastatic spread. Sever...

journal_title：BMC cancer

authors： Avery-Kiejda KA,Braye SG,Forbes JF,Scott RJ

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized that genetic variation as well as environmental factors modulate breast cancer risk. The main aim of th...

journal_title：BMC cancer

authors： Hadjisavvas A,Loizidou MA,Middleton N,Michael T,Papachristoforou R,Kakouri E,Daniel M,Papadopoulos P,Malas S,Marcou Y,Kyriacou K

更新日期：2010-08-23 00:00:00

abstract：BACKGROUND:Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinoma models and to compare the findings with those reported for primary tumors of the gland. METHODS:W...

journal_title：BMC cancer

authors： Ribeiro FR,Meireles AM,Rocha AS,Teixeira MR

更新日期：2008-12-16 00:00:00

abstract：BACKGROUND:The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment. METHODS:Between January 1996 and December 2006, a total of 1367 CRC patients who ...

journal_title：BMC cancer

authors： Sun LC,Chu KS,Cheng SC,Lu CY,Kuo CH,Hsieh JS,Shih YL,Chang SJ,Wang JY

更新日期：2009-08-20 00:00:00

abstract：BACKGROUND:To determine the safety and efficacy of transarterial chemoembolization (TACE) combined with radiofrequency ablation (hereafter, TACE-RFA) in treating Barcelona Clinic Liver Cancer (BCLC) Stage A or B (hereafter, BCLC A/B) hepatocellular carcinoma (HCC) patients, and to explore the range of tumor sizes suita...

journal_title：BMC cancer

authors： Ren Y,Cao Y,Ma H,Kan X,Zhou C,Liu J,Shi Q,Feng G,Xiong B,Zheng C

更新日期：2019-10-22 00:00:00

abstract：BACKGROUND:The 5-year overall survival rates for head and neck cancer (HNC) relies on distant metastasis. Importantly, the epithelial-mesenchymal transition (EMT) is believed to be an initial step of metastasis. However, the relationship of epigenetic with EMT formation is still unexplored in HNC. This study focuses on...

journal_title：BMC cancer

authors： Chen LH,Hsu WL,Tseng YJ,Liu DW,Weng CF

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:Pelvic inflammatory disease (PID) is characterized by infection and inflammation of the upper genital tract in women and is associated with health sequelae. We used a nationwide population-based retrospective cohort study to explore the relationship between PID and the subsequent development of gynecological...

journal_title：BMC cancer

authors： Shen CC,Hu LY,Yang AC,Chiang YY,Hung JH,Tsai SJ

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:The incidence of Cholangiocellular Carcinoma (CCA) is increasing in the western world. The tumour has a high proportion of desmoplastic stroma and is correlated with a worse prognosis when cancer associated myofibroblasts (CAFs) are present. Recent studies showed promising results after liver transplantation...

journal_title：BMC cancer

authors： Heits N,Heinze T,Bernsmeier A,Kerber J,Hauser C,Becker T,Kalthoff H,Egberts JH,Braun F

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the preferred surgical approach worldwide. However, this procedure is associated with considerable morbidity. Several meta-analyses have shown an advantage in ...

journal_title：BMC cancer

authors： Haverkamp L,Brenkman HJ,Seesing MF,Gisbertz SS,van Berge Henegouwen MI,Luyer MD,Nieuwenhuijzen GA,Wijnhoven BP,van Lanschot JJ,de Steur WO,Hartgrink HH,Stoot JH,Hulsewé KW,Spillenaar Bilgen EJ,Rütter JE,Kouwenhoven EA,van

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:Staging of B-cell non Hodgkin's lymphoma (NHL) routinely involves bone marrow (BM) examination by trephine biopsy (BM-TB). The evidence of disease in the BM-TB results in a clinical stage IV classification affecting therapeutic strategies for NHL patients. BM immunophenotyping by flow cytometry (FC) is also ...

journal_title：BMC cancer

authors： Mancuso P,Calleri A,Antoniotti P,Quarna J,Pruneri G,Bertolini F

更新日期：2010-11-24 00:00:00

abstract：BACKGROUND:Toll-like receptor 3 (TLR3) is a critical component of the innate immune response to dsRNA viruses, which was considered to be mainly expressed in immune cells and some endothelial cells. In this study, we investigated the expression and proapoptotic activity of TLR3 in human and murine tumor cell lines. ME...

journal_title：BMC cancer

authors： Jiang Q,Wei H,Tian Z

更新日期：2008-01-17 00:00:00

abstract：BACKGROUND:The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness and perineural invas...

journal_title：BMC cancer

authors： Huang SF,Chien HT,Cheng SD,Chuang WY,Liao CT,Wang HM

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cancer (PCa) aggressivenes...

journal_title：BMC cancer

authors： Dozmorov MG,Azzarello JT,Wren JD,Fung KM,Yang Q,Davis JS,Hurst RE,Culkin DJ,Penning TM,Lin HK

更新日期：2010-12-06 00:00:00

abstract：BACKGROUND:Primary treatment of carcinoma of the oro-/hypopharynx or larynx may consist of combined platinum-containing chemoradiotherapy. In order to improve clinical outcome (i.e. local control/overall survival), combined therapy is intensified by the addition of the EGFR inhibitor cetuximab (Erbitux®). Radiation the...

journal_title：BMC cancer

authors： Habl G,Jensen AD,Potthoff K,Uhl M,Hof H,Hajda J,Simon C,Debus J,Krempien R,Münter MW

更新日期：2010-11-26 00:00:00

abstract：BACKGROUND:The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for this population, and compare its performance to a widely used overseas model, the Nottingham Prognosti...

journal_title：BMC cancer

authors： Elwood JM,Tawfiq E,TinTin S,Marshall RJ,Phung TM,Campbell I,Harvey V,Lawrenson R

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...

journal_title：BMC cancer

authors： Gerlier L,Lamotte M,Awada A,Bosly A,Bries G,Cocquyt V,Focan C,Henry S,Lalami Y,Machiels JP,Mebis J,Straetmans N,Verhoeven D,Somers L

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...

journal_title：BMC cancer

authors： Ryan AV,Wilson S,Wakelam MJ,Warmington SA,Dunn JA,Hobbs RF,Martin A,Ismail T

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...

journal_title：BMC cancer

authors： Colonna M,Mitton N,Bossard N,Belot A,Grosclaude P,French Network of Cancer Registries (FRANCIM).

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied the potential function of miR-124 in CCA and the mechanism of GATA6 regulation. METHODS:The expressio...

journal_title：BMC cancer

authors： Tian F,Chen J,Zheng S,Li D,Zhao X,Jiang P,Li J,Wang S

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...

journal_title：BMC cancer

authors： Chen YH,Lu HI,Lo CM,Wang YM,Chou SY,Hsiao CC,Huang CC,Shih LH,Chen SW,Li SH

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community. We examined treatment patterns, outcomes, and disease-related mortality in patients ≥ 75 years with CLL...

journal_title：BMC cancer

authors： Nabhan C,Mato A,Flowers CR,Grinblatt DL,Lamanna N,Weiss MA,Davids MS,Swern AS,Bhushan S,Sullivan K,Flick ED,Kiselev P,Sharman JP

更新日期：2017-03-16 00:00:00

abstract：BACKGROUND:Non-muscle invasive bladder cancer (NMIBC) is usually treated with local therapy including transurethral resection of the bladder tumor and intravesical therapy depending on the stage of the tumor. NMIBC is a rarely a metastatic diseases with lymph node invasion in less of 10%. In the other hand meningeal ca...

journal_title：BMC cancer

authors： Teyssonneau D,Daste A,Dousset V,Hoepffner JL,Ravaud A,Gross-Goupil M

更新日期：2017-05-11 00:00:00

abstract：BACKGROUND:The cholesterol biosynthesis pathway is typically upregulated in breast cancer. The role of NAD(P)-dependent steroid dehydrogenase-like (NSDHL) gene, which is involved in cholesterol biosynthesis, in breast cancer remains unknown. This study aimed to uncover the role of NSDHL in the growth and metastasis of ...

journal_title：BMC cancer

authors： Yoon SH,Kim HS,Kim RN,Jung SY,Hong BS,Kang EJ,Lee HB,Moon HG,Noh DY,Han W

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans. METHODS:Medical records of African Americans,...

journal_title：BMC cancer

authors： Brim H,Zahaf M,Laiyemo AO,Nouraie M,Pérez-Pérez GI,Smoot DT,Lee E,Razjouyan H,Ashktorab H

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutati...

journal_title：BMC cancer

authors： Kitkumthorn N,Yanatatsanajit P,Kiatpongsan S,Phokaew C,Triratanachat S,Trivijitsilp P,Termrungruanglert W,Tresukosol D,Niruthisard S,Mutirangura A

更新日期：2006-03-08 00:00:00

abstract：BACKGROUND:Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. However, inherent heterogeneity and treatment-induced adaptation to drugs c...

journal_title：BMC cancer

authors： Shahi Thakuri P,Gupta M,Singh S,Joshi R,Glasgow E,Lekan A,Agarwal S,Luker GD,Tavana H

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...

journal_title：BMC cancer

authors： Jassim GA,Whitford DL

更新日期：2013-04-28 00:00:00