Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines.

abstract：BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...

journal_title：BMC cancer

authors： Dai SD,Wang Y,Miao Y,Zhao Y,Zhang Y,Jiang GY,Zhang PX,Yang ZQ,Wang EH

更新日期：2009-06-09 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c. ...

journal_title：BMC cancer

authors： Nilsson G,Kannius-Janson M

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were to evaluate the needs in cancer inpatients and to improve the understanding of the meanings of the n...

journal_title：BMC cancer

authors： Tamburini M,Gangeri L,Brunelli C,Boeri P,Borreani C,Bosisio M,Karmann CF,Greco M,Miccinesi G,Murru L,Trimigno P

更新日期：2003-04-23 00:00:00

abstract：BACKGROUND:Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovar...

journal_title：BMC cancer

authors： Vilming Elgaaen B,Olstad OK,Haug KB,Brusletto B,Sandvik L,Staff AC,Gautvik KM,Davidson B

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α), transcriptional regulators of several genes involved in...

journal_title：BMC cancer

authors： Chintala S,Najrana T,Toth K,Cao S,Durrani FA,Pili R,Rustum YM

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is effective against sarcoma 180 (S180) at exceptionally high doses and these mice remain healthy. METHOD...

journal_title：BMC cancer

authors： Riedlinger G,Adams J,Stehle JR Jr,Blanks MJ,Sanders AM,Hicks AM,Willingham MC,Cui Z

更新日期：2010-05-03 00:00:00

abstract：BACKGROUND:Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to ...

journal_title：BMC cancer

authors： Thumallapally N,Meshref A,Mousa M,Terjanian T

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding stron...

journal_title：BMC cancer

authors： Thomas SK,Cha SC,Smith DL,Kim KH,Parshottam SR,Rao S,Popescu M,Lee VY,Neelapu SS,Kwak LW

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in t...

journal_title：BMC cancer

authors： Bonde AK,Tischler V,Kumar S,Soltermann A,Schwendener RA

更新日期：2012-01-24 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify the risk factors associated with fatal pulmonary hemorrhage (PH) in patients with locally advanced non-small cell lung cancer (NSCLC), treated with chemoradiotherapy. METHODS:The medical records of 583 patients with locally advanced NSCLC, who were treated with chem...

journal_title：BMC cancer

authors： Ito M,Niho S,Nihei K,Yoh K,Ohmatsu H,Ohe Y

更新日期：2012-01-20 00:00:00

abstract：BACKGROUND:The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts surviva...

journal_title：BMC cancer

authors： Westgaard A,Tafjord S,Farstad IN,Cvancarova M,Eide TJ,Mathisen O,Clausen OP,Gladhaug IP

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. METHODS:Here, additi...

journal_title：BMC cancer

authors： Bacopulos S,Amemiya Y,Yang W,Zubovits J,Burger A,Yaffe M,Seth AK

更新日期：2012-02-08 00:00:00

abstract：BACKGROUND:Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of ...

journal_title：BMC cancer

authors： Folyovich A,Varga V,Várallyay G,Kozák L,Bakos M,Scheidl E,Béres-Molnár KA,Kajdácsi Z,Bereczki D

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. Here, to determine the relationship of LAD1 with colorectal cancer progression, we explored the effec...

journal_title：BMC cancer

authors： Moon B,Yang SJ,Park SM,Lee SH,Song KS,Jeong EJ,Park M,Kim JS,Yeom YI,Kim JA

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and JAK2 are critical for inflamm...

journal_title：BMC cancer

authors： von Bubnoff N,Ihorst G,Grishina O,Röthling N,Bertz H,Duyster J,Finke J,Zeiser R

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney cancer is rising across the sexes in some of these countries, a trend which may possibly reflect the ...

journal_title：BMC cancer

authors： López-Abente G,Aragonés N,Pérez-Gómez B,Ramis R,Vidal E,García-Pérez J,Fernández-Navarro P,Pollán M

更新日期：2008-10-09 00:00:00

abstract：BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...

journal_title：BMC cancer

authors： Yang GF,He WP,Cai MY,He LR,Luo JH,Deng HX,Guan XY,Zeng MS,Zeng YX,Xie D

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...

journal_title：BMC cancer

authors： Jensen H,Tørring ML,Olesen F,Overgaard J,Fenger-Grøn M,Vedsted P

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablating metastatic lesions and may play a synergistic role with immunotherapy. The purpose of this study ...

journal_title：BMC cancer

authors： Bahig H,Aubin F,Stagg J,Gologan O,Ballivy O,Bissada E,Nguyen-Tan FP,Soulières D,Guertin L,Filion E,Christopoulos A,Lambert L,Tehfe M,Ayad T,Charpentier D,Jamal R,Wong P

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. METHODS:PRL-3 genomic a...

journal_title：BMC cancer

authors： Ooki A,Yamashita K,Kikuchi S,Sakuramoto S,Katada N,Waraya M,Kawamata H,Nishimiya H,Nakamura K,Watanabe M

更新日期：2011-04-06 00:00:00

abstract：BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...

journal_title：BMC cancer

authors： Wu Z,Zhao J,Gao P,Song Y,Sun J,Chen X,Ma B,Wang Z

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated in several other cancers, its role in non-small cell lung cancer (NSCLC) is unknown. The aim of the present st...

journal_title：BMC cancer

authors： Liu XH,Lu KH,Wang KM,Sun M,Zhang EB,Yang JS,Yin DD,Liu ZL,Zhou J,Liu ZJ,De W,Wang ZX

更新日期：2012-08-09 00:00:00

abstract：BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...

journal_title：BMC cancer

authors： Carroll MJ,Parent CR,Page D,Kreeger PK

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:Cancer services are inaccessible in many low-income countries, and few published examples describe oncology programs within the public sector. In 2011, the Rwanda Ministry of Health (RMOH) established Butaro Cancer Center of Excellence (BCCOE) to expand cancer services nationally. In hopes of informing cance...

journal_title：BMC cancer

authors： Tapela NM,Mpunga T,Hedt-Gauthier B,Moore M,Mpanumusingo E,Xu MJ,Nzayisenga I,Hategekimana V,Umuhizi DG,Pace LE,Bigirimana JB,Wang J,Driscoll C,Uwizeye FR,Drobac PC,Ngoga G,Shyirambere C,Muhayimana C,Lehmann L,Shulma

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imagi...

journal_title：BMC cancer

authors： Qiu C,Bai Y,Yin T,Miao X,Gao R,Zhou H,Ren J,Song L,Liu C,Zheng H,Zheng R

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that independently arising neoplasms in an individual patient would exhibit measurable genomic variation, en...

journal_title：BMC cancer

authors： Shen C,Xu H,Liu L,Zhou Y,Chen D,Du H,Han Z,Che G

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...

journal_title：BMC cancer

authors： von Bergwelt-Baildon M,Hallek MJ,Shimabukuro-Vornhagen AA,Kochanek M

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to identify the magnitude of delayed diagnosis and its associated factors in women with breast cancer in...

journal_title：BMC cancer

authors： Norsa'adah B,Rampal KG,Rahmah MA,Naing NN,Biswal BM

更新日期：2011-04-17 00:00:00

abstract：BACKGROUND:Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on smoking sta...

journal_title：BMC cancer

authors： Vucic EA,Thu KL,Pikor LA,Enfield KS,Yee J,English JC,MacAulay CE,Lam S,Jurisica I,Lam WL

更新日期：2014-10-24 00:00:00