Abstract:
BACKGROUND:Cancer services are inaccessible in many low-income countries, and few published examples describe oncology programs within the public sector. In 2011, the Rwanda Ministry of Health (RMOH) established Butaro Cancer Center of Excellence (BCCOE) to expand cancer services nationally. In hopes of informing cancer care delivery in similar settings, we describe program-level experience implementing BCCOE, patient characteristics, and challenges encountered. METHODS:Butaro Cancer Center of Excellence was founded on diverse partnerships that emphasize capacity building. Services available include pathology-based diagnosis, basic imaging, chemotherapy, surgery, referral for radiotherapy, palliative care and socioeconomic access supports. Retrospective review of electronic medical records (EMR) of patients enrolled between July 1, 2012 and June 30, 2014 was conducted, supplemented by manual review of paper charts and programmatic records. RESULTS:In the program's first 2 years, 2326 patients presented for cancer-related care. Of these, 70.5% were female, 4.3% children, and 74.3% on public health insurance. In the first year, 66.3% (n = 1144) were diagnosed with cancer. Leading adult diagnoses were breast, cervical, and skin cancer. Among children, nephroblastoma, acute lymphoblastic leukemia, and Hodgkin lymphoma were predominant. As of June 30, 2013, 95 cancer patients had died. Challenges encountered include documentation gaps and staff shortages. CONCLUSION:Butaro Cancer Center of Excellence demonstrates that complex cancer care can be delivered in the most resource-constrained settings, accessible to vulnerable patients. Key attributes that have made BCCOE possible are: meaningful North-south partnerships, innovative task- and infrastructure-shifting, RMOH leadership, and an equity-driven agenda. Going forward, we will apply our experiences and lessons learned to further strengthen BCCOE, and employ the developed EMR system as a valuable platform to assess long-term clinical outcomes and improve care.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Tapela NM,Mpunga T,Hedt-Gauthier B,Moore M,Mpanumusingo E,Xu MJ,Nzayisenga I,Hategekimana V,Umuhizi DG,Pace LE,Bigirimana JB,Wang J,Driscoll C,Uwizeye FR,Drobac PC,Ngoga G,Shyirambere C,Muhayimana C,Lehmann L,Shulmadoi
10.1186/s12885-016-2256-7subject
Has Abstractpub_date
2016-03-18 00:00:00pages
237issn
1471-2407pii
10.1186/s12885-016-2256-7journal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of the CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 gene polymorphisms and tobacco smok...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4342-5
更新日期:2018-05-03 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequently reported in sporadic breast cancers, but few studies have focused on profiling hereditary breast ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6640-y
更新日期:2020-02-22 00:00:00
abstract:BACKGROUND:Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, little is known about the contribution of environmental tobacco smoke (ETS) to RCC incidence. This study...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-387
更新日期:2008-12-24 00:00:00
abstract:BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-631
更新日期:2010-11-18 00:00:00
abstract:BACKGROUND:A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and novel therap...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06922-1
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2712-4
更新日期:2016-08-19 00:00:00
abstract:BACKGROUND:Rhabdoid tumors are rare cancers of early childhood arising in the kidney, central nervous system and other organs. The majority are caused by somatic inactivating mutations or deletions affecting the tumor suppressor locus SMARCB1 [OMIM 601607]. Germ-line SMARCB1 inactivation has been reported in associatio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-437
更新日期:2009-12-13 00:00:00
abstract:BACKGROUND:Interpretation of comparative health-related quality of life (HRQOL) studies following different prostate cancer treatments is often difficult due to differing patient ages. Furthermore, age-related changes can hardly be discriminated from therapy-related changes. The evaluation of age-and comorbidity-relate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-296
更新日期:2009-08-24 00:00:00
abstract:BACKGROUND:Whether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unknown and need to be investigated. METHODS:305 MBC patients with luminal subtypes were screened with P...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-42
更新日期:2013-01-31 00:00:00
abstract:BACKGROUND:The aim of this study was to compare surgical treatment received by Aboriginal and non-Aboriginal people with non-small cell lung cancer (NSCLC) in New South Wales (NSW), Australia and to examine whether patient and disease characteristics are associated with any disparities found. An additional objective wa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2322-1
更新日期:2016-04-25 00:00:00
abstract:BACKGROUND:For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3844-x
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to evaluate tumor response simulating different conditions of administration of antiangiogenic treatment (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-403
更新日期:2014-06-04 00:00:00
abstract:OBJECTIVE:Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this study was to explore the efficacy of crizotinib in advanced non-small-cell lung cancer (NSCLC) with c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5078-y
更新日期:2018-11-26 00:00:00
abstract:BACKGROUND:Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development remains controversial. This study evaluated the impact of DJ compared to nephrostomy placement during ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6620-2
更新日期:2020-02-21 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this disease. However, the mechanism of miRNA-induced mRNA cleavage remains to be investigated. METHOD:In...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06717-4
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-282
更新日期:2013-06-11 00:00:00
abstract:BACKGROUND:We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment. METHODS:We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2504-x
更新日期:2016-07-20 00:00:00
abstract:BACKGROUND:Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus. In our previous studies, we have shown that TTC9A was a hormonally-regulated gene in breast cancer cells. In this study, we found that TTC9A was over-ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-231
更新日期:2008-08-12 00:00:00
abstract:BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-662
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma (PMBCL). However, their CNA-based profile and clinical impact still remain unc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07293-3
更新日期:2020-08-27 00:00:00
abstract:BACKGROUND:Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis. The arginine-lowering agent PEGylated arginine deiminase (ADI-PEG 20) has shown efficacy as a monot...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-621
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4965-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in cellular density of irradiated cancerous tissue will lead to an increase in quantitative apparent d...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6617-x
更新日期:2020-02-19 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) in patients with resectable thoracic esophageal squamo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2696-0
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Pro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2431-x
更新日期:2016-07-07 00:00:00
abstract:BACKGROUND:Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dialysis. The objective of the FASTRACK II clinical trial is to investigate the efficacy of SABR for pr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4916-2
更新日期:2018-10-23 00:00:00
abstract:BACKGROUND:Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions of miRNAs have been shown to affect miRNA expression. Therefore, we aimed to analyze the effect of m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5641-1
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Isothiocyanates are natural compounds found in consumable cruciferous vegetables. They have been shown to inhibit chemical carcinogenesis by a wide variety of chemical carcinogens in animal models. Recent studies have also shown that isothiocyanates have antitumor activity, inhibiting the growth of several t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-269
更新日期:2010-06-09 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies. This study aimed to identify the key prognosis impacting genes and relevant subtypes for LUAD. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6462-y
更新日期:2020-01-27 00:00:00
abstract:BACKGROUND:Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing and analyzing data from large-scale projects, such as TCGA, is a demanding task. It is difficult to di...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5965-x
更新日期:2019-08-20 00:00:00