Systematical identifications of prognostic meaningful lung adenocarcinoma subtypes and the underlying mutational and expressional characters.

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. METHODS:The in vitro antineoplastic effect and mechanism of action of Casiopei...

journal_title：BMC cancer

authors： Trejo-Solís C,Jimenez-Farfan D,Rodriguez-Enriquez S,Fernandez-Valverde F,Cruz-Salgado A,Ruiz-Azuara L,Sotelo J

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluate...

journal_title：BMC cancer

authors： Wu Y,Ye S,Goswami S,Pei X,Xiang L,Zhang X,Yang H

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Myopericytoma is a rare and usually benign tumor, which is even rarer if it occurs in the liver and stomach space. Previous reports of myopericytoma were mostly related to its pathological manifestations, while imaging reports were rare. Here, we report the computed tomography (CT), computed tomography angio...

journal_title：BMC cancer

authors： Chen Z,Liang W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. METHODS:PRL-3 genomic a...

journal_title：BMC cancer

authors： Ooki A,Yamashita K,Kikuchi S,Sakuramoto S,Katada N,Waraya M,Kawamata H,Nishimiya H,Nakamura K,Watanabe M

更新日期：2011-04-06 00:00:00

abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...

journal_title：BMC cancer

authors： Ryan AV,Wilson S,Wakelam MJ,Warmington SA,Dunn JA,Hobbs RF,Martin A,Ismail T

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activation mechanism of PaSCs is not yet known. The Notch signaling pathway, components of which are express...

journal_title：BMC cancer

authors： Song H,Zhang Y

更新日期：2018-01-05 00:00:00

abstract：BACKGROUND:Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone receptors (PR) and response to tamoxifen is unknown. Interleukin-6 (IL-6) and interleukin-8 (IL-8) may i...

journal_title：BMC cancer

authors： Schillace RV,Skinner AM,Pommier RF,O'Neill S,Muller PJ,Naik AM,Hansen JE,Pommier SJ

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the cancer. Here, we sought to identify a molecular signature based on S100A8 expression and to assess ...

journal_title：BMC cancer

authors： Kim SK,Kim EJ,Leem SH,Ha YS,Kim YJ,Kim WJ

更新日期：2010-01-25 00:00:00

abstract：BACKGROUND:BCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCOR mutation in lymphoid malignancies is unknown. METHODS:Lymphoma patient samples were analyzed to i...

journal_title：BMC cancer

authors： Kang JH,Lee SH,Lee J,Choi M,Cho J,Kim SJ,Kim WS,Ko YH,Yoo HY

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...

journal_title：BMC cancer

authors： Ma Q,Shilkrut M,Zhao Z,Li M,Batty N,Barber B

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...

journal_title：BMC cancer

authors： Rouissi K,Bahria IB,Bougatef K,Marrakchi R,Stambouli N,Hamdi K,Cherif M,Ben Slama MR,Sfaxi M,Othman FB,Chebil M,Elgaaied AB,Ouerhani S

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND:To evaluate the effect of Recurrence Score® results (RS; Oncotype DX® multigene assay ODX) on treatment recommendations by Swiss multidisciplinary tumor boards (TB). METHODS:SAKK 26/10 is a multicenter, prospective cohort study of early breast cancer patients: Eligibility: R0-resection, ≥10% ER+ malignant c...

journal_title：BMC cancer

authors： Pestalozzi BC,Tausch C,Dedes KJ,Rochlitz C,Zimmermann S,von Moos R,Winterhalder R,Ruhstaller T,Mueller A,Buser K,Borner M,Novak U,Nussbaum CU,Seifert B,Bigler M,Bize V,Vilei SB,Rageth C,Aebi S,Swiss Group for Clinic

更新日期：2017-04-13 00:00:00

abstract：BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...

journal_title：BMC cancer

authors： Korja M,Jokilammi A,Salmi TT,Kalimo H,Pelliniemi TT,Isola J,Rantala I,Haapasalo H,Finne J

更新日期：2009-02-17 00:00:00

abstract：BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thy...

journal_title：BMC cancer

authors： Bradley NL,Wiseman SM

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeasures against IBD-associated neoplasia are crucial. The purpose of this study is to develop a new dia...

journal_title：BMC cancer

authors： Kinugasa H,Hiraoka S,Nouso K,Yamamoto S,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Takahara M,Harada K,Tanaka T,Okada H

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 and 3 clinical trials where its efficacy and safety was found to be similar to its reference product...

journal_title：BMC cancer

authors： Kamioner D,Fruehauf S,Maloisel F,Cals L,Lepretre S,Berthou C

更新日期：2013-11-16 00:00:00

abstract：BACKGROUND:The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablating metastatic lesions and may play a synergistic role with immunotherapy. The purpose of this study ...

journal_title：BMC cancer

authors： Bahig H,Aubin F,Stagg J,Gologan O,Ballivy O,Bissada E,Nguyen-Tan FP,Soulières D,Guertin L,Filion E,Christopoulos A,Lambert L,Tehfe M,Ayad T,Charpentier D,Jamal R,Wong P

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the outcomes of current approaches necessitate an ongoing evaluation of the epidemiology and mortality-tre...

journal_title：BMC cancer

authors： Saad AM,Turk T,Al-Husseini MJ,Abdel-Rahman O

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in patients with metastatic/relapsed STS following failure of prior chemotherapy by examining data colle...

journal_title：BMC cancer

authors： Wagner MJ,Amodu LI,Duh MS,Korves C,Solleza F,Manson SC,Diaz J,Neary MP,Demetri GD

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. METHODS:We used high-throughp...

journal_title：BMC cancer

authors： Celestino R,Nome T,Pestana A,Hoff AM,Gonçalves AP,Pereira L,Cavadas B,Eloy C,Bjøro T,Sobrinho-Simões M,Skotheim RI,Soares P

更新日期：2018-01-10 00:00:00

abstract：BACKGROUND:Adjuvant endocrine therapy can improve disease-free survival and time before recurrence in breast cancer patients. However, it is associated with considerable side effects that negatively affect patients' quality of life and cause non-adherence. The recently demonstrated effect of individual expectations on ...

journal_title：BMC cancer

authors： von Blanckenburg P,Schuricht F,Albert US,Rief W,Nestoriuc Y

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...

journal_title：BMC cancer

authors： Bruin SC,Klijn C,Liefers GJ,Braaf LM,Joosse SA,van Beers EH,Verwaal VJ,Morreau H,Wessels LF,van Velthuysen ML,Tollenaar RA,Van't Veer LJ

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...

journal_title：BMC cancer

authors： Jassim GA,Whitford DL

更新日期：2013-04-28 00:00:00

abstract：BACKGROUND:In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. METHODS:Taiwan Cancer Registry records of 9039 subjects diagnos...

journal_title：BMC cancer

authors： Chen PH,Shieh TY,Ho PS,Tsai CC,Yang YH,Lin YC,Ko MS,Tsai PC,Chiang SL,Tu HP,Ko YC

更新日期：2007-06-15 00:00:00

abstract：BACKGROUND:Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, including CAPRA-S, are currently used for disease prognostication. However, high...

journal_title：BMC cancer

authors： Kamdar S,Fleshner NE,Bapat B

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA region) were identified in the 3p21.3 region. We have shown previously that homozygous deletions in A...

journal_title：BMC cancer

authors： Senchenko VN,Anedchenko EA,Kondratieva TT,Krasnov GS,Dmitriev AA,Zabarovska VI,Pavlova TV,Kashuba VI,Lerman MI,Zabarovsky ER

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The primary aim of treatment of a patient who has developed metastatic disease is palliation. The objectives of the current study are to describe and quantify the clinical management of women with metastatic breast cancer from the diagnosis of metastatic disease until death and to analyze differences between...

journal_title：BMC cancer

authors： Manders K,van de Poll-Franse LV,Creemers GJ,Vreugdenhil G,van der Sangen MJ,Nieuwenhuijzen GA,Roumen RM,Voogd AC

更新日期：2006-07-06 00:00:00

abstract：BACKGROUND:For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the preferred surgical approach worldwide. However, this procedure is associated with considerable morbidity. Several meta-analyses have shown an advantage in ...

journal_title：BMC cancer

authors： Haverkamp L,Brenkman HJ,Seesing MF,Gisbertz SS,van Berge Henegouwen MI,Luyer MD,Nieuwenhuijzen GA,Wijnhoven BP,van Lanschot JJ,de Steur WO,Hartgrink HH,Stoot JH,Hulsewé KW,Spillenaar Bilgen EJ,Rütter JE,Kouwenhoven EA,van

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:Long-term survival in numerous cancers often correlates with specific whole transcriptome profiles or the expression patterns of smaller numbers of transcripts. In some instances, these are better predictors of survival than are standard classification methods such as clinical stage or hormone receptor statu...

journal_title：BMC cancer

authors： Mandel J,Avula R,Prochownik EV

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield higher BED, shorten the total treatmen...

journal_title：BMC cancer

authors： Ren XC,Wang QY,Zhang R,Chen XJ,Wang N,Liu YE,Zong J,Guo ZJ,Wang DY,Lin Q

更新日期：2016-04-23 00:00:00