Study design: two long-term observational studies of the biosimilar filgrastim Nivestim™ (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia.

abstract：BACKGROUND:Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a contr...

journal_title：BMC cancer

authors： Dorn J,Spatz H,Schmieder M,Barth TF,Blatz A,Henne-Bruns D,Knippschild U,Kramer K

更新日期：2010-07-02 00:00:00

abstract：BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...

journal_title：BMC cancer

authors： Wu Z,Zhao J,Gao P,Song Y,Sun J,Chen X,Ma B,Wang Z

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. METHODS:Here we investigated genomic aberrations affecting genes of the intrinsic apop...

journal_title：BMC cancer

authors： Lamers F,Schild L,Koster J,Speleman F,Øra I,Westerhout EM,van Sluis P,Versteeg R,Caron HN,Molenaar JJ

更新日期：2012-07-12 00:00:00

abstract：BACKGROUND:The prognostic value of histone γ-H2AX and 53BP1 proteins to predict the radiotherapy (RT) outcome of patients with rectal carcinoma (RC) was evaluated in a prospective study. High expression of the constitutive histone γ-H2AX is indicative of defective DNA repair pathway and/or genomic instability, whereas ...

journal_title：BMC cancer

authors： Djuzenova CS,Zimmermann M,Katzer A,Fiedler V,Distel LV,Gasser M,Waaga-Gasser AM,Flentje M,Polat B

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Several studies have described an increased cyclooxygenase-2 (COX-2) expression in pancreatic cancer, but the role of COX-2 in tumour development and progression is not clear. The aim of the present study was to examine expression of COX-2 in cancer cells and stromal cells in pancreatic cancer specimens, and...

journal_title：BMC cancer

authors： Pomianowska E,Sandnes D,Grzyb K,Schjølberg AR,Aasrum M,Tveteraas IH,Tjomsland V,Christoffersen T,Gladhaug IP

更新日期：2014-06-09 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist...

journal_title：BMC cancer

authors： Huang J,Zhang YL,Teng XM,Lin Y,Zheng DL,Yang PY,Han ZG

更新日期：2007-07-12 00:00:00

abstract：BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...

journal_title：BMC cancer

authors： Adam Y,van Gelderen CJ,de Bruyn G,McIntyre JA,Turton DA,Martinson NA

更新日期：2008-07-25 00:00:00

abstract：:Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...

journal_title：BMC cancer

authors： Jiann BP

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...

journal_title：BMC cancer

authors： Gornjec A,Novakovic S,Stegel V,Hocevar M,Pohar Marinsek Z,Gazic B,Krajc M,Skof E

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Myopericytoma is a rare and usually benign tumor, which is even rarer if it occurs in the liver and stomach space. Previous reports of myopericytoma were mostly related to its pathological manifestations, while imaging reports were rare. Here, we report the computed tomography (CT), computed tomography angio...

journal_title：BMC cancer

authors： Chen Z,Liang W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...

journal_title：BMC cancer

authors： Zhang L,Li Z,Liu Y,Xu S,Tandon M,Appelboom B,LaValle CR,Chiosea SI,Wang L,Sen M,Lui VWY,Grandis JR,Wang QJ

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvir...

journal_title：BMC cancer

authors： Simon PS,Sharman SK,Lu C,Yang D,Paschall AV,Tulachan SS,Liu K

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate socio-demographic characteristics of clients claiming genetic counseling for hereditary breast and ovarian cancer (HBOC) in Austria. Furthermore, changes of these parameters before and after Angelina Jolie's (AJ) disclosure of carrying a BRCA mutation were evaluated....

journal_title：BMC cancer

authors： Staudigl C,Pfeiler G,Hrauda K,Renz R,Berger A,Lichtenschopf R,Singer CF,Tea MK

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA...

journal_title：BMC cancer

authors： Powell AA,Akare S,Qi W,Herzer P,Jean-Louis S,Feldman RA,Martinez JD

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Translationally controlled tumor protein (TCTP), alternatively called fortilin, is believed to be involved in the development of the chemoresistance of tumor cells against anticancer drugs such as etoposide, taxol, and oxaliplatin, the underlying mechanisms of which still remain elusive. METHODS:Cell death ...

journal_title：BMC cancer

authors： Jung J,Kim HY,Maeng J,Kim M,Shin DH,Lee K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer. METHODS:To further understand Herceptin resistance mechanisms at the molecular level, we used comparative proteome approaches to analyze two human ...

journal_title：BMC cancer

authors： Kang SH,Kang KW,Kim KH,Kwon B,Kim SK,Lee HY,Kong SY,Lee ES,Jang SG,Yoo BC

更新日期：2008-10-04 00:00:00

abstract：BACKGROUND:Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects rel...

journal_title：BMC cancer

authors： Dimou A,Barron G,Merrick DT,Kolfenbach J,Doebele RC

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in cancer invasion, metastasis, and chemoresistance. Additionally, EMT is partially responsible for che...

journal_title：BMC cancer

authors： Zhang Z,Zheng S,Lin Y,Sun J,Ding N,Chen J,Zhong J,Shi L,Xue M

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...

journal_title：BMC cancer

authors： Benedicto A,Marquez J,Herrero A,Olaso E,Kolaczkowska E,Arteta B

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:There is no consensus regarding resection of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastatic colorectal cancer (CRC). A potential benefit of resection of the primary tumour is to prevent complications of the primary tumour in later stages of the disease. We...

journal_title：BMC cancer

authors： 't Lam-Boer J,Mol L,Verhoef C,de Haan AF,Yilmaz M,Punt CJ,de Wilt JH,Koopman M

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) reported remarkable achievements in several solid tumours. However, in metastatic colorectal cancer (mCRC) promising results are limited to patients with deficient mismatch repair/microsatellite instability-high (dMMR/MSI-high) tumours due to their immune-enriched microenv...

journal_title：BMC cancer

authors： Antoniotti C,Borelli B,Rossini D,Pietrantonio F,Morano F,Salvatore L,Lonardi S,Marmorino F,Tamberi S,Corallo S,Tortora G,Bergamo F,Brunella DS,Boccaccino A,Grassi E,Racca P,Tamburini E,Aprile G,Moretto R,Boni L,Fa

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...

journal_title：BMC cancer

authors： Yang GF,He WP,Cai MY,He LR,Luo JH,Deng HX,Guan XY,Zeng MS,Zeng YX,Xie D

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:Glioblastoma is the most common and most aggressive form of malignant glioma and is very difficult to treat. Controlling tumour cell invasion and angiogenesis is essential to improve the prognosis of glioblastoma patients. Since constitutive activation of nuclear factor-κB (NF-κB) is necessary for tumour pro...

journal_title：BMC cancer

authors： Nakabayashi H,Shimizu K

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expressed in the kidneys, little is known about their influence on human renal cancer. METHODS:To clarify...

journal_title：BMC cancer

authors： Betsunoh H,Fukuda T,Anzai N,Nishihara D,Mizuno T,Yuki H,Masuda A,Yamaguchi Y,Abe H,Yashi M,Fukabori Y,Yoshida K,Kamai T

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (EPC) leading to revascularization and renewed growth within the residual tumor. This study investiga...

journal_title：BMC cancer

authors： Nguyen L,Fifis T,Christophi C

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...

journal_title：BMC cancer

authors： Matsumoto M,Seike M,Noro R,Soeno C,Sugano T,Takeuchi S,Miyanaga A,Kitamura K,Kubota K,Gemma A

更新日期：2015-04-09 00:00:00

abstract：:Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published. ...

journal_title：BMC cancer

authors： Doma V,Kárpáti S,Rásó E,Barbai T,Tímár J

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...

journal_title：BMC cancer

authors： Carroll MJ,Parent CR,Page D,Kreeger PK

更新日期：2019-10-31 00:00:00

abstract：:Following publication of the original article [1], the authors reported the following error is the article. ...

journal_title：BMC cancer

authors： Ye S,Hao X,Zhou T,Wu M,Wei J,Wang Y,Zhou L,Jiang X,Ji L,Chen Y,You L,Zhang Y,Xu G,Zhou J,Ma D,Wang S

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. METHODS:Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We con...

journal_title：BMC cancer

authors： Zhou PY,Tang Z,Liu WR,Tian MX,Jin L,Jiang XF,Wang H,Tao CY,Ding ZB,Peng YF,Qiu SJ,Dai Z,Zhou J,Fan J,Shi YH

更新日期：2017-11-14 00:00:00