Involvement of Akt/NF-κB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo.

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...

journal_title：BMC cancer

authors： Jiang H,Xu S,Chen C

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:We evaluated if the survival benefit of adding rituximab to standard chemotherapy for non-Hodgkin lymphoma (NHL) observed in clinical trials has been experienced by an Australian NHL patient population. METHODS:NHL cases diagnosed in 1985-2004 in New South Wales (NSW) were followed-up to the end of 2004. Ri...

journal_title：BMC cancer

authors： Yu XQ,Chen WH,O'Connell DL

更新日期：2010-05-24 00:00:00

abstract：BACKGROUND:Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this study was to evaluate whether the presence of disseminated tumor cells in bone marrow from patients ...

journal_title：BMC cancer

authors： Vogelaar FJ,Mesker WE,Rijken AM,van Pelt GW,van Leeuwen AM,Tanke HJ,Tollenaar RA,Liefers GJ

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal carcinoma (IDC). The prognosis of IMPC compared with that of IDC remains controversial; we conducted a meta-analysis to evaluate the prognostic difference between IMPC and IDC. METHODS:We searched the PubMed, Cochran...

journal_title：BMC cancer

authors： Wu Y,Zhang N,Yang Q

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there is also an overexpression of CXCR4 and an obvious involvement in gastric cancer metastasis. The aim o...

journal_title：BMC cancer

authors： Zhao C,Lu X,Bu X,Zhang N,Wang W

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncogene or a tumour suppressor, depending on the origin of the cancer. Only a few studies have reported ...

journal_title：BMC cancer

authors： Jeong D,Heo S,Sung Ahn T,Lee S,Park S,Kim H,Park D,Byung Bae S,Lee SS,Soo Lee M,Kim CJ,Jun Baek M

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of primary PMHE in which denosumab treatment showed activity in both imaging studies and the clinical ou...

journal_title：BMC cancer

authors： Otani S,Nakayama R,Sekita T,Hirozane T,Asano N,Nishimoto K,Sasaki A,Okita H,Morioka H,Nakamura M,Matsumoto M

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In this study, which examined the value of serum TRAP concentrations as ...

journal_title：BMC cancer

authors： Honig A,Rieger L,Kapp M,Krockenberger M,Eck M,Dietl J,Kämmerer U

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of contention. METHODS:A database of 386 patients, enrolled in a randomized clinical trial on the effect of a...

journal_title：BMC cancer

authors： Demicheli R,Ambrogi F

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:Distinguishing between multiple primary lung cancers and metastatic tumors is often difficult when the tumor histology is same. Since genomic instability is a common feature of cancer, we hypothesized that independently arising neoplasms in an individual patient would exhibit measurable genomic variation, en...

journal_title：BMC cancer

authors： Shen C,Xu H,Liu L,Zhou Y,Chen D,Du H,Han Z,Che G

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:The prevalence of patients with gastrointestinal stromal tumourgst (GIST) who fail currently available treatments imatinib and sunitinib (third-line treatment-eligible GIST) is unknown, but is expected to be below an ultra-orphan disease threshold of 2/100,000 population used in England and Wales. Our study ...

journal_title：BMC cancer

authors： Starczewska Amelio JM,Cid Ruzafa J,Desai K,Tzivelekis S,Muston D,Khalid JM,Ashman P,Maguire A

更新日期：2014-05-24 00:00:00

abstract：BACKGROUND:Stereotactic radiotherapy is an emerging treatment option for patients with inoperable renal cell carcinoma (RCC). Haemorrhage has not previously been reported to occur as a result of Stereotactic Body Radiotherapy (SBRT) to the kidney for primary RCC. We report an acute haemorrhage in a patient who received...

journal_title：BMC cancer

authors： Hilleary LA,Wratten C,Siva S,Hilleary J,Martin JM

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Wilms' tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms' tumor. MiRNAs play important roles in this tumorigenic process. In the present study, we aimed to investigate the role of m...

journal_title：BMC cancer

authors： Liu Z,He F,OuYang S,Li Y,Ma F,Chang H,Cao D,Wu J

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...

journal_title：BMC cancer

authors： Cong J,Gong J,Yang C,Xia Z,Zhang H

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:For decades, planar bone scintigraphy has been the standard practice for detection of bone metastases in prostate cancer and has been endorsed by recent oncology/urology guidelines. It is a sensitive method with modest specificity. (18)F-fluoride positron emission tomography/computed tomography has shown imp...

journal_title：BMC cancer

authors： Fonager RF,Zacho HD,Langkilde NC,Petersen LJ

更新日期：2016-01-11 00:00:00

abstract：BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...

journal_title：BMC cancer

authors： Mikhitarian K,Martin RH,Ruppel MB,Gillanders WE,Hoda R,Schutte del H,Callahan K,Mitas M,Cole DJ

更新日期：2008-02-20 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive and most likely combines environmental and genetic factors. The Kv2.1 potassium channel encoded by KC...

journal_title：BMC cancer

authors： Barbirou M,Woldu HG,Sghaier I,Bedoui SA,Mokrani A,Aami R,Mezlini A,Yacoubi-Loueslati B,Tonellato PJ,Bouhaouala-Zahar B

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health. This paper reports on trends in the geographical mortality patterns of the most frequent cancers in Spain, over a period of 2...

journal_title：BMC cancer

authors： López-Abente G,Aragonés N,Pérez-Gómez B,Pollán M,García-Pérez J,Ramis R,Fernández-Navarro P

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its u...

journal_title：BMC cancer

authors： Song Q,Chen Q,Wang Q,Yang L,Lv D,Jin G,Liu J,Li B,Fei X

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

journal_title：BMC cancer

authors： Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer is poorly characterized at genetic and non-genetic levels. The current study evaluates in a large cohort of patients the prognostic relevance of molecular subtypes and key transcription factors in pancreatic ductal adenocarcinoma (PDAC). METHODS:We performed gene expression analysis of who...

journal_title：BMC cancer

authors： Janky R,Binda MM,Allemeersch J,Van den Broeck A,Govaere O,Swinnen JV,Roskams T,Aerts S,Topal B

更新日期：2016-08-12 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal and tumor cells. These proteins appear to have a key role in the tumor microenvironment for cancer development and metastasis. There is little information regarding the prognostic value of the combination of ...

journal_title：BMC cancer

authors： Rouanne M,Adam J,Goubar A,Robin A,Ohana C,Louvet E,Cormier J,Mercier O,Dorfmüller P,Fattal S,de Montpreville VT,Lebret T,Dartevelle P,Fadel E,Besse B,Olaussen KA,Auclair C,Soria JC

更新日期：2016-07-15 00:00:00

abstract：BACKGROUND:Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unkno...

journal_title：BMC cancer

authors： Niavarani SR,Lawson C,Bakos O,Boudaud M,Batenchuk C,Rouleau S,Tai LH

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...

journal_title：BMC cancer

authors： Stücker I,Loriot MA,N'koutchou G,Cénée S,Bodin L,Mulot C,Gelu-Simeon M,Pelletier L,Bronowicki JP,Degos F,Beaune P,Laurent-Puig P,Hémon D,Trinchet JC,Pelletier G

更新日期：2007-11-19 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OSA) still demands further investigation. This study aimed at probing into the function of hsa_circ_00...

journal_title：BMC cancer

authors： Li H,He L,Tuo Y,Huang Y,Qian B

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...

journal_title：BMC cancer

authors： Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JH

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC. METHODS:We employed 2 human ESCC cell lines, Eca109 and TE-1, as the model system. The effect of miR-203 and ΔNp63 on cell proliferati...

journal_title：BMC cancer

authors： Yuan Y,Zeng ZY,Liu XH,Gong DJ,Tao J,Cheng HZ,Huang SD

更新日期：2011-02-07 00:00:00

abstract：BACKGROUND:Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment and highly specialized skill sets. METHODS:We have designed and developed an assay, CpGlobal, which ...

journal_title：BMC cancer

authors： Anisowicz A,Huang H,Braunschweiger KI,Liu Z,Giese H,Wang H,Mamaev S,Olejnik J,Massion PP,Del Mastro RG

更新日期：2008-08-03 00:00:00

abstract：BACKGROUND:We compared the outcome of patients who received non-image-guided intensity-modulated radiotherapy (IMRT) with those who received helical tomotherapy (HT), a daily image-guided radiotherapy (IGRT), after surgery for oral cavity cancer (OCC). METHODS:During the period November 2006 to December 2013, a total ...

journal_title：BMC cancer

authors： Hsieh CH,Shueng PW,Wang LY,Huang YC,Liao LJ,Lo WC,Lin YC,Wu LJ,Tien HJ

更新日期：2016-02-23 00:00:00