Abstract:
BACKGROUND:Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its upregulator remains largely unknown. miRNA modulate gene expression by post-transcriptional repression to participate in many signaling pathway of breast cancer cell proliferation. miR-590 has been reported to regulate tumorgenesis and could be regulated by its own target ATF-3. But whether miR-590 can be the modulator of Golgi related genes to regulate the breast cancer proliferation is unclear. METHODS:We performed the bioinformatics analysis of survival rate and expression differences of patients using the data of The Cancer Genome Atlas (TCGA).Both of MTS and BrdU assays were used for cell proliferation analysis. Cell cycle was detected by flow cytometry .qRT-PCR was used for detecting the cell cycle related gene expression. Student's t-test or One way anova was used for statistics. RESULTS:We found the upregulation of GOLPH3 in breast cancer samples compared with normal breast tissues, which also was related to the poor prognosis. Overexpression of GOLPH3 significantly promoted proliferation both of MDA-MB-231 cells (ER negative) and MCF-7 cells (ER positive). We further found that miRNA-590-3p could directly target the 3'-UTR of GOLPH3 mRNA to repress its expression. Overexpression of miR-590-3p inhibited the proliferation of MDA-MB-231 and MCF-7 cells. The rescue experiments indicated that overexpression of GOLPH3 significantly resorted the proliferation inhibited by miR-590-3p. We also found that ATF-3 repressed miR-590-3p expression to modulate miR-590/GOLPH3 pathway to regulate breast cancer cells proliferation. CONCLUSIONS:This study not only suggests that the ATF-3/miR-590/GOLPH3 signaling pathway is critically involved in the proliferation of breast cancer cells, but provides a novel therapeutic target and new insight base on epigenetic regulation for future breast cancer diagnosis and clinical treatment.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Song Q,Chen Q,Wang Q,Yang L,Lv D,Jin G,Liu J,Li B,Fei Xdoi
10.1186/s12885-018-4031-4subject
Has Abstractpub_date
2018-03-09 00:00:00pages
255issue
1issn
1471-2407pii
10.1186/s12885-018-4031-4journal_volume
18pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4914-4
更新日期:2018-10-19 00:00:00
abstract:BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were de...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-566
更新日期:2012-12-02 00:00:00
abstract:BACKGROUND:Prostate cancer is the single most prevalent cancer in US men whose gold standard of diagnosis is histologic assessment of biopsies. Manual assessment of stained tissue of all biopsies limits speed and accuracy in clinical practice and research of prostate cancer diagnosis. We sought to develop a fully-autom...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-62
更新日期:2011-02-09 00:00:00
abstract:BACKGROUND:Breast cancer risk, development, and treatment are influenced by genetic variation in certain genes, namely those involved in cell proliferation, tumor suppression, and drug metabolism. In turn, the relevance of the aforementioned genetic variation to cancer depends on the ethnic group in question, highlight...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6490-7
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS:We here investigated a represent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-58
更新日期:2005-06-03 00:00:00
abstract:BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-018-4699-5
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Total mesorectal excision is the standard surgical treatment for mid- and low-rectal cancer. Laparoscopy represents a clear leap forward in the management of rectal cancer patients, offering significant improvements in post-operative measures such as pain, first bowel movement, and hospital length of stay. H...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3200-1
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2749-4
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the investigated data from patient charts and patient-reported outcome (PRO) up to 14 years after therap...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6635-8
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:The 3rd isoform of the metallothionein (MT3) gene family has been shown to be overexpressed in most ductal breast cancers. A previous study has shown that the stable transfection of MCF-7 cells with the MT3 gene inhibits cell growth. The goal of the present study was to determine the role of the unique C-ter...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3355-9
更新日期:2017-05-25 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this disease. However, the mechanism of miRNA-induced mRNA cleavage remains to be investigated. METHOD:In...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06717-4
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been reported where it has significant correlation with the cancer cell proliferation. However, the functi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-928
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Cancer has a lot of consequences on patients' quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients' partners and their relationship, such as distress and communication difficulties. These consequences are undertreated, and interventions based on hy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5046-6
更新日期:2018-11-15 00:00:00
abstract:BACKGROUND:The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the popu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5153-4
更新日期:2018-12-11 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer. METHODS:Eleven consecutive patients with obstructing left-sided colon cancer between May 2014 and November 2...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6560-x
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 expression in tumors has been discussed, but hepatocellular carcinoma (HCC) has not been included in these ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3460-9
更新日期:2017-07-07 00:00:00
abstract:BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-4
更新日期:2008-01-13 00:00:00
abstract:BACKGROUND:Loss of lean body mass (LBM) is a common occurrence after treatment for breast cancer and is related to deleterious metabolic health outcomes [Clin Oncol, 22(4):281-288, 2010; Appl Physiol Nutr Metab, 34(5):950-956, 2009]. The aim of this research is to determine the effectiveness of long chain omega-3 fatty...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-14-264
更新日期:2014-04-16 00:00:00
abstract:BACKGROUND:The sex hormone-binding globulin (SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-60
更新日期:2007-04-05 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07766-5
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1131-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:Febrile neutropenia (FN) is common in breast cancer patients undergoing chemotherapy. Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This study aimed to evaluate the predictive value of patient-related, chemotherapy-related, and genetic risk...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-201
更新日期:2014-03-19 00:00:00
abstract:BACKGROUND:Extramural tumor deposits (TDs) and extracapsular lymph node involvement (ECLNI) are considered to be poor prognostic factors in patients with T3-4, N0-2, M0 colorectal cancer (CRC). Although TDs are known to have multiple origins and pleomorphic features, the prognostic significances of the different type o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1885-6
更新日期:2015-11-06 00:00:00
abstract:BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-566
更新日期:2010-10-19 00:00:00
abstract:BACKGROUND:Diets that restrict energy or macronutrient intake (e.g. fasting/ketogenic diets (KDs)) may selectively protect non-tumour cells during cancer treatment. Previous reviews have focused on a subset of dietary restrictions (DR) or have not performed systematic searches. We conducted a systematic scoping review ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5931-7
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3595-8
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2701-7
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4965-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-501
更新日期:2012-10-30 00:00:00
abstract:BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-497
更新日期:2013-10-25 00:00:00