Abstract:
BACKGROUND:The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the population of NSCLC patients who develop acquired resistance due to the T790M mutation. In this study, we focused on the emergence of the T790M mutation and analyzed patients refractory to initial EGFR-TKIs with successful re-biopsy samples. METHODS:Seventy-eight advanced NSCLC patients with EGFR mutations who had successful re-biopsy samples after resistance to initial EGFR-TKI treatment were enrolled at 5 institutions in Japan. We validated the association between the emergence of the T790M mutation and their clinical profiles. RESULTS:Thirty-nine patients tested positive for T790M and 39 tested negative in the re-biopsy samples. The objective response rate to initial EGFR-TKIs was higher in patients with the T790M mutation than in those without the mutation (89.7% versus 51.2%, p < 0.001). Moreover, there was a significant difference in the maximal tumor shrinkage rate relative to baseline in T790M-positive tumors compared with T790M-negative tumors (42.7% versus 24.0%, p = 0.001). Multivariate analysis demonstrated that the maximum tumor shrinkage rate was a significant predictive factor for the detection of the T790M mutation (p = 0.023, odds ratio 1.03, 95% confidence interval 1.00-1.05). CONCLUSIONS:Our retrospective observations suggested that the maximum tumor shrinkage rate with initial EGFR-TKI treatment might be one of the promising predictive biomarkers for emerging refractory tumors with the EGFR-T790M mutation.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Yoshimura A,Yamada T,Okura N,Takeda T,Furutani W,Kubota Y,Shiotsu S,Hiranuma O,Nishioka N,Chihara Y,Tamiya N,Kaneko Y,Uchino J,Takayama Kdoi
10.1186/s12885-018-5153-4subject
Has Abstractpub_date
2018-12-11 00:00:00pages
1241issue
1issn
1471-2407pii
10.1186/s12885-018-5153-4journal_volume
18pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Patients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal function as a complication of their treatment. The presence of pancreatic metastases in patients with metastatic renal carcinoma, often confers a more favourable prognosis and a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6215-y
更新日期:2019-10-17 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the feasibility and potential benefit of a brief psychosocial intervention based on cognitive-behavioral therapy performed in addition to early palliative care (PC) in the reduction of depressive symptoms among patients with advanced cancer. METHODS:An open-label randomiz...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-017-3560-6
更新日期:2017-08-23 00:00:00
abstract:BACKGROUND:Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, little is known about the contribution of environmental tobacco smoke (ETS) to RCC incidence. This study...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-387
更新日期:2008-12-24 00:00:00
abstract:BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07347-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:To investigate the association between physical activity (PA) and quality of life (QoL) among breast and colorectal cancer survivors in Korea. METHODS:A total of 224 cancer survivors (151 breast and 73 colorectal cancers) who completed treatments were recruited. We measured PA level with Godin Leisure-Time ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06819-z
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme of sequentially occurring Copy Number Alterations (CNAs). METHODS:In this work we set to determine ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-121
更新日期:2014-02-22 00:00:00
abstract:BACKGROUND:In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make compliance with protocol-driven treatment challenging in low- and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6611-3
更新日期:2020-03-29 00:00:00
abstract:BACKGROUND:The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcino...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-30
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Utilisation of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) for diagnosis and staging of lung cancer is gaining popularity, however, its impact on clinical practice is unclear. This study aimed to determine the impact of the introduction of endobronc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2081-z
更新日期:2016-01-28 00:00:00
abstract:BACKGROUND:Wilms' tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms' tumor. MiRNAs play important roles in this tumorigenic process. In the present study, we aimed to investigate the role of m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5609-1
更新日期:2019-04-29 00:00:00
abstract:BACKGROUND:Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast cancer to achieve a better prognosis for individuals suffering from breast cancer. MicroRNAs (miRNAs) h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07395-y
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. Smoking often occurs in social groups, therefore interventions which target families and individuals...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3344-z
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA1/BRCA2 inactivation during cancer development will be helpful for more effective treatments. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-146
更新日期:2013-03-22 00:00:00
abstract:BACKGROUND:The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancer...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-123
更新日期:2011-04-07 00:00:00
abstract:BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-57
更新日期:2009-02-17 00:00:00
abstract:BACKGROUND:Hypoxia is a common characteristic of solid tumors associated with reduced response to radio- and chemotherapy, therefore increasing the probability of tumor recurrence. The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells. METHODS:MDA-MB-231...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-391
更新日期:2012-09-06 00:00:00
abstract:BACKGROUND:Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2. METHODS:ATC were generated from PBMC activated for 14 days with anti-CD3 monoclonal antibody in th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-83
更新日期:2013-02-22 00:00:00
abstract:BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-214
更新日期:2007-11-19 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This stu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2801-4
更新日期:2016-10-18 00:00:00
abstract:BACKGROUND:Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet Union to Germany (resettlers) to those living in Russia as well as to the German and the Russian gene...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6058-6
更新日期:2019-09-02 00:00:00
abstract:BACKGROUD:The incidence of recurrent laryngeal nerve (RLN) injury has increased due to RLN lymph node dissection. The aim of this study was to evaluate the ability of intraoperative ultrasonography (IU) to detect RLN nodal metastases in esophageal cancer patients. METHODS:Sixty patients with esophageal cancer underwen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4643-8
更新日期:2018-07-13 00:00:00
abstract:BACKGROUND:The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival rates of only 50-60%. Neo-adjuvant and adjuvant chemotherapy (CTX) has been applied to achieve pre-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-510
更新日期:2011-12-07 00:00:00
abstract:BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3385-3
更新日期:2017-05-31 00:00:00
abstract:BACKGROUND:Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression of several cancers such as breast cancer. Here, the consequence of NAMPT inhibition by miR-154 was ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6221-0
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral blood lymphocytes (PBLs) and glioma risk has not been investigated. METHODS:Real-time PCR was used t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-680
更新日期:2014-09-19 00:00:00
abstract:BACKGROUND:High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood stem cell (PBSC) grafts can be challenging, and the question arises whether reinfusion of low-dose gra...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06873-7
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-311
更新日期:2010-06-21 00:00:00
abstract:BACKGROUND:Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published report...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-555
更新日期:2012-11-24 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovarian cancer (EOC). METHODS:Patients diagnosed with EOC during 2012-2015 were analyzed retrospectivel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3476-1
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Needle core biopsy, often in conjunction with ultrasonic or stereotactic guided techniques, is frequently used to diagnose breast carcinoma in women. Confocal scanning laser microscopy (CSLM) is a technology that provides real-time digital images of tissues with cellular resolution. This paper reports the pr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-265
更新日期:2009-08-03 00:00:00