Abstract:
BACKGROUND:Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet Union to Germany (resettlers) to those living in Russia as well as to the German and the Russian general populations. METHODS:The cancer registry of North Rhine-Westphalia identified incident cases of stomach, colorectal, lung, breast and prostate cancer in resettlers and the general population of the administrative district of Münster (Germany) between 2004 and 2013. The Tomsk cancer registry collected the same data in ethnic Germans and the general population of the Tomsk region (Russia). We used standardised incidence rate ratios (SIRs) to compare rates of resettlers and ethnic Germans with the respective general populations. RESULTS:The total number of person-years under risk was 83,289 for ethnic Germans, 8,006,775 for the population of Tomsk, 219,604 for resettlers, and 20,516,782 for the population of Münster. Incidence of the five investigated cancer types among ethnic Germans did not differ from incidence of the general population of Tomsk. Compared to the general population of Tomsk, incidence among resettlers was higher for colorectal cancer in both sexes (females: SIR 1.45 [95% CI 1.14-1.83], males: SIR 1.56 [95% CI 1.23-1.97]), breast cancer in females (SIR 1.65 [95% CI 1.40-1.95]), and prostate cancer (SIR 1.64 [95% CI 1.34-2.01]). Incidence rates of these cancer types among resettlers were more similar to rates of the general population of Münster. Incidence of stomach and lung cancer did not differ between resettlers and the general population of Tomsk. CONCLUSIONS:After an average stay of 15 years, we observed that incidence of colorectal, breast and prostate cancer among resettlers converged to levels of the general population of Münster. Resettler's incidence of stomach and lung cancer, however, was comparable to incidence in their population of origin. Causes must be investigated in subsequent analytical studies.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Jaehn P,Kaucher S,Pikalova LV,Mazeina S,Kajüter H,Becher H,Valkov M,Winkler Vdoi
10.1186/s12885-019-6058-6subject
Has Abstractpub_date
2019-09-02 00:00:00pages
869issue
1issn
1471-2407pii
10.1186/s12885-019-6058-6journal_volume
19pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investigate the ability of EHD1 [Eps15 homology (EH) domain - containing protein 1] to confer CDDP resistanc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2527-3
更新日期:2016-07-13 00:00:00
abstract:BACKGROUND:Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation, inhibition of apoptosis, increased invasion and metastasis, and chemoresista...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1539-8
更新日期:2015-07-25 00:00:00
abstract::Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. H...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-020-07561-2
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Breast metastasis from lung cancer has been reported, but not from SCLC that is transformed from lung adenocarcinoma during maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Transformation to small cell lung cancer(SCLC), although uncommonly seen, has been asso...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2623-4
更新日期:2016-08-03 00:00:00
abstract:BACKGROUND:Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This study investigated the role of hyaluronan (HA) and a potential link between the HA-CD44 pathway and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-476
更新日期:2013-10-14 00:00:00
abstract:BACKGROUND:There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patien...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4121-3
更新日期:2018-02-21 00:00:00
abstract:BACKGROUND:The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005. METHODS:Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS wa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-622
更新日期:2010-11-10 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6638-5
更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-352
更新日期:2011-08-12 00:00:00
abstract:BACKGROUND:To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use. METHODS:Pubmed and Embase were searched up the terms radiomics or radiogenomics and gliomas or glioblastomas until February 2019. From 189 articles, 51 ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-6504-5
更新日期:2020-01-10 00:00:00
abstract:BACKGROUND:Ongoing improvements in technique and instruments for video-assisted thoracoscopic surgery (VATS) have made minimally-invasive uniportal VATS lobectomy a reality. However, the outcomes of the procedure are still under investigation, and at present, uniportal VATS lobectomy is performed infrequently at most h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3069-z
更新日期:2017-01-25 00:00:00
abstract:BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-99
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC). METHODS:The specimens of NSCLC from 305 Chinese patients with follow-up were analyzed for CD133 protein expression and VM by immunohistochemical and histoche...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-535
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Given their frequency of occurrence in the United States, cancer and heart disease often coexist. For patients requiring open-heart surgery, this raises concern that the use of cardiopulmonary bypass (CPB) may cause a transient immunosuppression with the potential to promote the spread and growth of coexisti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-519
更新日期:2013-11-03 00:00:00
abstract:BACKGROUND:The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy. METHODS:Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-102
更新日期:2010-03-18 00:00:00
abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3762-y
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast cancer. The current study evaluated the prognostic impact of TOP2A protein on luminal breast cancer....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4170-7
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07081-z
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CNB) or vacuum-assisted biopsy (VAB). A meta-analysis reported that 25.9% of invasive ductal carcinoma (IDC) cases are preoperat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07001-1
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investig...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-363
更新日期:2013-07-29 00:00:00
abstract:BACKGROUND:The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with renal cell carcinoma (RCC). METHODS:EZH2 protein expression in RC...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-524
更新日期:2010-10-04 00:00:00
abstract:BACKGROUND:The purpose of this case report is to describe a conjunctiva and eyelid Kaposi's sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection. CAS...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4611-3
更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:Gastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor survival. The phenotypic characterization of the diffuse gastric cancer cell line can be useful for gastric cancer researchers. In this article, we aimed to characterize the dif...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06814-4
更新日期:2020-04-15 00:00:00
abstract:BACKGROUND:The 5-year overall survival rates for head and neck cancer (HNC) relies on distant metastasis. Importantly, the epithelial-mesenchymal transition (EMT) is believed to be an initial step of metastasis. However, the relationship of epigenetic with EMT formation is still unexplored in HNC. This study focuses on...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2468-x
更新日期:2016-07-08 00:00:00
abstract:BACKGROUND:There are strong indications for a causal association between areca-nut consumption and cancers. In Meghalaya, India, the variety of areca-nut is used as raw and unprocessed form whose chemical composition and pharmacological actions have been reported. Yet we know little on the initial pathway involved in a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-315
更新日期:2013-06-28 00:00:00
abstract:BACKGROUND:The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-464
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component. CASE PRESENTATION:A 47-year-old woman presented with left breas...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-736
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Humans are exposed to an array of both harmful and beneficial hormonally active compounds in the environment and through diet. Two such chemicals are Bisphenol A (BPA), a plasticizer, and genistein, a component of soy. Prepubertal exposure to BPA increased mammary carcinogenesis, while genistein suppressed c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-379
更新日期:2014-05-29 00:00:00
abstract:BACKGROUND:Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine strategy that integrates genomic profiling and preclinical drug-screening platforms, in order to persona...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3525-9
更新日期:2017-08-10 00:00:00
abstract:BACKGROUND:Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In this study, which examined the value of serum TRAP concentrations as ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-199
更新日期:2006-07-25 00:00:00