Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma.

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC cancer

authors： Al-Khayal K,Vaali-Mohammed MA,Elwatidy M,Traiki TB,Al-Obeed O,Azam M,Khan Z,Abdulla M,Ahmad R

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. ...

journal_title：BMC cancer

authors： Radoï L,Menvielle G,Cyr D,Lapôtre-Ledoux B,Stücker I,Luce D,ICARE Study Group.

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and novel therap...

journal_title：BMC cancer

authors： Choi J,Topouza DG,Tarnouskaya A,Nesdoly S,Koti M,Duan QL

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:To evaluate efficacy in patients with brain metastasis (BM) on entry into the lapatinib expanded access program (LEAP). METHODS:LEAP is a worldwide, single-arm, open-label study. HER2-positive, locally-advanced or metastatic breast cancer patients with progression after an anthracycline, taxane, and trastuz...

journal_title：BMC cancer

authors： Ro J,Park S,Kim S,Kim TY,Im YH,Rha SY,Chung JS,Moon H,Santillana S

更新日期：2012-07-28 00:00:00

abstract：BACKGROUND:Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the an...

journal_title：BMC cancer

authors： Yue T,Zheng X,Dou Y,Zheng X,Sun R,Tian Z,Wei H

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations. METHODS:From a multi-institutiona...

journal_title：BMC cancer

authors： Redana S,Donadio M,Nolè F,Jacomuzzi ME,Beano A,Martinello R,Sapino A,Viale G,Aglietta M,Montemurro F

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immunotherapy plays an important auxiliary role in the treatment of advanced OV patient, so it is of gre...

journal_title：BMC cancer

authors： Yan S,Fang J,Chen Y,Xie Y,Zhang S,Zhu X,Fang F

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Medical oncologists continue to use performance status as a proxy for quality of life (QOL) measures, as completion of QOL instruments is perceived as time consuming, may measure aspects of QOL not affected by cancer therapy, and interpretation may be unclear. The pulse oximeter is widely used in clinical pr...

journal_title：BMC cancer

authors： Martins SJ,Ho N,Cavamura SO,Harada CM,Yamamoto CA,Takagaki TY

更新日期：2005-07-06 00:00:00

abstract：BACKGROUND:Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic vir...

journal_title：BMC cancer

authors： Schäfer S,Weibel S,Donat U,Zhang Q,Aguilar RJ,Chen NG,Szalay AA

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:The preoperative characterization of thyroid nodules is a challenge for the clinicians. Fine-needle aspiration (FNA) is the commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. There ...

journal_title：BMC cancer

authors： Arcolia V,Paci P,Dhont L,Chantrain G,Sirtaine N,Decaestecker C,Remmelink M,Belayew A,Saussez S

更新日期：2014-07-08 00:00:00

abstract：BACKGROUND:There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable prognosis compared with HPV-negative OPSCC, leading to investigation and adoption of de-escalation trea...

journal_title：BMC cancer

authors： Nopmaneepaisarn T,Tangjaturonrasme N,Rawangban W,Vinayanuwattikun C,Keelawat S,Bychkov A

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as effective antineoplastic drugs for several malignant tumors. We hypothesized that Selumetinib might be ...

journal_title：BMC cancer

authors： Zhou Y,Lin S,Tseng KF,Han K,Wang Y,Gan ZH,Min DL,Hu HY

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Diabetes is related with increased cancer mortality across multiple cancer types. Its role in lung cancer mortality is still unclear. We aim to determine the prognostic value of fasting plasma glucose (FPG) and diabetes mellitus in patients with locally advanced non-small cell lung cancer (NSCLC) treated wit...

journal_title：BMC cancer

authors： Bergamino M,Rullan AJ,Saigí M,Peiró I,Montanya E,Palmero R,Ruffinelli JC,Navarro A,Arnaiz MD,Brao I,Aso S,Padrones S,Cardenal F,Nadal E

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in cellular density of irradiated cancerous tissue will lead to an increase in quantitative apparent d...

journal_title：BMC cancer

authors： Fliedner FP,Engel TB,El-Ali HH,Hansen AE,Kjaer A

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to sex, genetic background and lifestyle. Here, we compute the individual phase of the Circadian Timing...

journal_title：BMC cancer

authors： Ortiz-Tudela E,Innominato PF,Rol MA,Lévi F,Madrid JA

更新日期：2016-04-21 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...

journal_title：BMC cancer

authors： Call J,Walentas CD,Eickhoff JC,Scherzer N

更新日期：2012-03-19 00:00:00

abstract：BACKGROUND:Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20-25% of new female cancer incidents. This study aimed to describe the temporal trend of breast cancer and interpret the potential effects on the observed secular trends. METHODS:Cancer incident ...

journal_title：BMC cancer

authors： Wang F,Tse LA,Chan WC,Kwok CC,Leung SL,Wu C,Mang OW,Ngan RK,Li M,Yu WC,Tsang KH,Law SH,Miao X,Wu C,Zheng Y,Wu F,Yang XR,Yu IT

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because many patients have multiple co-morbidities and would not fulfill the eligibility criteria of clinical...

journal_title：BMC cancer

authors： Schlumpf M,Fischer C,Naehrig D,Rochlitz C,Buess M

更新日期：2013-12-27 00:00:00

abstract：BACKGROUND:Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral squamous cell carcinoma (OSCC) remain unclear. METHODS:We evaluated the expression profile and progno...

journal_title：BMC cancer

authors： Liu D,Jian X,Xu P,Zhu R,Wang Y

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed ...

journal_title：BMC cancer

authors： Batista LI,Lu KH,Beahm EK,Arun BK,Bodurka DC,Meric-Bernstam F

更新日期：2008-04-14 00:00:00

abstract：BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastrointestinal (GI) NETs with 177Lu-Dotatate resulted in a significant improvement in progression-free su...

journal_title：BMC cancer

authors： Smith-Palmer J,Leeuwenkamp OR,Virk J,Reed N

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expr...

journal_title：BMC cancer

authors： Stenzinger A,Endris V,Klauschen F,Sinn B,Lorenz K,Warth A,Goeppert B,Ehemann V,Muckenhuber A,Kamphues C,Bahra M,Neuhaus P,Weichert W

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining an individual's susceptibility to bladder cancer in particular when in combination with specific envi...

journal_title：BMC cancer

authors： McGrath M,Michaud D,De Vivo I

更新日期：2006-10-06 00:00:00

abstract：BACKGROUND:We investigated the role of the HIPK2-p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. METHODS:Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by im...

journal_title：BMC cancer

authors： Zhou L,Feng Y,Jin Y,Liu X,Sui H,Chai N,Chen X,Liu N,Ji Q,Wang Y,Li Q

更新日期：2014-10-05 00:00:00

abstract：BACKGROUND:Nivestim™ (filgrastim) is a follow-on biologic agent licensed in the EU for the treatment of neutropenia and febrile neutropenia induced by myelosuppressive chemotherapy. Nivestim™ has been studied in phase 2 and 3 clinical trials where its efficacy and safety was found to be similar to its reference product...

journal_title：BMC cancer

authors： Kamioner D,Fruehauf S,Maloisel F,Cals L,Lepretre S,Berthou C

更新日期：2013-11-16 00:00:00

abstract：BACKGROUND:In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor...

journal_title：BMC cancer

authors： Rouissi K,Bahria IB,Bougatef K,Marrakchi R,Stambouli N,Hamdi K,Cherif M,Ben Slama MR,Sfaxi M,Othman FB,Chebil M,Elgaaied AB,Ouerhani S

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...

journal_title：BMC cancer

authors： Liu YJ,Zhang Q,Hu SY,Zhao FH

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, including CAPRA-S, are currently used for disease prognostication. However, high...

journal_title：BMC cancer

authors： Kamdar S,Fleshner NE,Bapat B

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...

journal_title：BMC cancer

authors： Klenke S,Akdeli N,Stelmach P,Heukamp L,Schulte JH,Bachmann HS

更新日期：2019-03-18 00:00:00

abstract：BACKGROUND:The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were to evaluate the needs in cancer inpatients and to improve the understanding of the meanings of the n...

journal_title：BMC cancer

authors： Tamburini M,Gangeri L,Brunelli C,Boeri P,Borreani C,Bosisio M,Karmann CF,Greco M,Miccinesi G,Murru L,Trimigno P

更新日期：2003-04-23 00:00:00