Coordinated prophylactic surgical management for women with hereditary breast-ovarian cancer syndrome.

abstract：BACKGROUND:Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective. Thus, there is an urgent need to identify new alterna...

journal_title：BMC cancer

authors： Peraldo-Neia C,Cavalloni G,Soster M,Gammaitoni L,Marchiò S,Sassi F,Trusolino L,Bertotti A,Medico E,Capussotti L,Aglietta M,Leone F

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...

journal_title：BMC cancer

authors： Ventrucci G,de Mello MA,Gomes-Marcondes MC

更新日期：2002-04-15 00:00:00

abstract：BACKGROUND:Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection of patients who might benefit form adjuvant chemotherapy (ACT). Presence of circulating tumor DNA (ctDNA) is indicative for MRD and has hi...

journal_title：BMC cancer

authors： Schraa SJ,van Rooijen KL,van der Kruijssen DEW,Rubio Alarcón C,Phallen J,Sausen M,Simmons J,Coupé VMH,van Grevenstein WMU,Elias S,Verkooijen HM,Laclé MM,Bosch LJW,van den Broek D,Meijer GA,Velculescu VE,Fijneman RJA,Vin

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:The use of chemotherapy regimens with moderate or high risk of febrile neutropenia (defined as having a FN incidence of 10% or more) and the respective incidence and clinical management of FN in breast cancer and NHL has not been studied in Belgium. The existence of a medical need for G-CSF primary and secon...

journal_title：BMC cancer

authors： Gerlier L,Lamotte M,Awada A,Bosly A,Bries G,Cocquyt V,Focan C,Henry S,Lalami Y,Machiels JP,Mebis J,Straetmans N,Verhoeven D,Somers L

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. CASE PRESENTATION:We describe a pat...

journal_title：BMC cancer

authors： El Saghir NS,Elhajj II,Geara FB,Hourani MH

更新日期：2005-08-04 00:00:00

abstract：BACKGROUND:Overweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain over the lifetime in postmenopausal breast cancer is not well documented. METHODS:We conducted a pop...

journal_title：BMC cancer

authors： Cordina-Duverger E,Truong T,Anger A,Sanchez M,Arveux P,Kerbrat P,Guénel P

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual's susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development. METHO...

journal_title：BMC cancer

authors： Zhao P,Zou P,Zhao L,Yan W,Kang C,Jiang T,You Y

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Evasion of immune surveillance and suppression of the immune system are important hallmarks of tumorigenesis. The goal of this study was to establish distinct patterns that reflect a rectal tumors' immune-phenotype and to determine their relation to patient outcome. METHODS:The study population consisted of...

journal_title：BMC cancer

authors： Reimers MS,Engels CC,Putter H,Morreau H,Liefers GJ,van de Velde CJ,Kuppen PJ

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic vir...

journal_title：BMC cancer

authors： Schäfer S,Weibel S,Donat U,Zhang Q,Aguilar RJ,Chen NG,Szalay AA

更新日期：2012-08-23 00:00:00

abstract：BACKGROUND:Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate...

journal_title：BMC cancer

authors： Grant DJ,Chen Z,Howard LE,Wiggins E,De Hoedt A,Vidal AC,Carney ST,Squires J,Magyar CE,Huang J,Freedland SJ

更新日期：2017-07-03 00:00:00

abstract：BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...

journal_title：BMC cancer

authors： Yang GF,He WP,Cai MY,He LR,Luo JH,Deng HX,Guan XY,Zeng MS,Zeng YX,Xie D

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this meta-analysis to assess the efficacy and safety of the combination treatment in patients with advan...

journal_title：BMC cancer

authors： Cai R,Song R,Pang P,Yan Y,Liao Y,Zhou C,Wang S,Zhou X,Wang H,Zhang H,Sun H,Ma H

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer...

journal_title：BMC cancer

authors： Wang R,Chen S,Li C,Ng KT,Kong CW,Cheng J,Cheng SH,Li RA,Lo CM,Man K,Sun D

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest. However, knowledge about the biological mec...

journal_title：BMC cancer

authors： Hanf M,Chiron D,de Visme S,Touzeau C,Maisonneuve H,Jardel H,Pellat-Deceunynck C,Amiot M,le Gouill S

更新日期：2016-10-14 00:00:00

abstract：BACKGROUND:Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsR...

journal_title：BMC cancer

authors： Rodriguez BL,Yu Z,Chung WG,Weiss R,Cui Z

更新日期：2011-03-28 00:00:00

abstract：BACKGROUND:Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are a...

journal_title：BMC cancer

authors： Mihajlović J,Pechlivanoglou P,Miladinov-Mikov M,Zivković S,Postma MJ

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OSA) still demands further investigation. This study aimed at probing into the function of hsa_circ_00...

journal_title：BMC cancer

authors： Li H,He L,Tuo Y,Huang Y,Qian B

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Platelet to Lymphocyte ratio (PLR) is thought to be associated with a worse outcome in multiple types of cancer. However, the prognostic significance of PLR has not been investigated in the prostate cancer (PCa) patients receiving hormonal therapy. The objective of this study was to determine the prognostic ...

journal_title：BMC cancer

authors： Wang Y,Xu F,Pan J,Zhu Y,Shao X,Sha J,Wang Z,Cai Y,Liu Q,Dong B,Xue W,Huang Y

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:The incidence and survival rates for colorectal cancer in Australia are among the highest in the world. With population growth and ageing there are increasing numbers of colorectal cancer survivors in the community, yet little is known of their ongoing follow up and survivorship care experiences. This study ...

journal_title：BMC cancer

authors： Young JM,Durcinoska I,DeLoyde K,Solomon MJ

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment and highly specialized skill sets. METHODS:We have designed and developed an assay, CpGlobal, which ...

journal_title：BMC cancer

authors： Anisowicz A,Huang H,Braunschweiger KI,Liu Z,Giese H,Wang H,Mamaev S,Olejnik J,Massion PP,Del Mastro RG

更新日期：2008-08-03 00:00:00

abstract：BACKGROUND:The human pancreatic cancer cell line A818-6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benign, highly differentiated, duct-like pancreatic epithelial structure. This characteristic allowing A8...

journal_title：BMC cancer

authors： Tawfik D,Zaccagnino A,Bernt A,Szczepanowski M,Klapper W,Schwab A,Kalthoff H,Trauzold A

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Locally advanced or metastatic adenocarcinoma of the pancreas remains - despite the implementation of new chemotherapy protocols - a disease with short overall survival (OS). METHODS:Eighty-three patients were treated with locally advanced or metastatic adenocarcinoma of the pancreas with either FOLFIRINOX ...

journal_title：BMC cancer

authors： Vogl UM,Andalibi H,Klaus A,Vormittag L,Schima W,Heinrich B,Kafka A,Winkler T,Öhler L

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:The prognosis for patients with recurrent glioblastoma is still poor with a median survival between 3 and 6 months. Reports about the application of carmustine (BCNU), one of the standard chemotherapeutic drugs in the treatment of newly diagnosed glioblastoma, in the recurrent situation are rare. METHODS:We...

journal_title：BMC cancer

authors： Reithmeier T,Graf E,Piroth T,Trippel M,Pinsker MO,Nikkhah G

更新日期：2010-02-02 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib is used for mRCC chemotherapy based on the favorable results of a recent clinical trial, but specifi...

journal_title：BMC cancer

authors： Takayoshi K,Sagara K,Uchino K,Kusaba H,Sakamoto N,Iguchi A,Baba E

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Young age remains a controversial issue as a prognostic factor in breast cancer. Debate includes patients from different parts of the world. Almost 50% of patients with breast cancer seen at the American University of Beirut Medical Center (AUBMC) are below age 50. METHODS:We reviewed 1320 patients seen at ...

journal_title：BMC cancer

authors： El Saghir NS,Seoud M,Khalil MK,Charafeddine M,Salem ZK,Geara FB,Shamseddine AI

更新日期：2006-07-20 00:00:00

abstract：BACKGROUND:This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma. METHODS:Of the entire cohort (N = 216), 108 patients were assigned to a test group and 108 patients to a validation group. In the test group, nine pre-trea...

journal_title：BMC cancer

authors： Douglas S,Schild SE,Rades D

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour ...

journal_title：BMC cancer

authors： Diessner J,Wischnewsky M,Stüber T,Stein R,Krockenberger M,Häusler S,Janni W,Kreienberg R,Blettner M,Schwentner L,Wöckel A,Bartmann C

更新日期：2016-05-12 00:00:00

abstract：BACKGROUND:Alterations in the redox balance are involved in the origin, promotion and progression of cancer. Inter-individual differences in the oxidative stress regulation can explain a part of the variability in cancer susceptibility.The aim of this study was to evaluate if polymorphisms in genes codifying for the di...

journal_title：BMC cancer

authors： Rodrigues P,de Marco G,Furriol J,Mansego ML,Pineda-Alonso M,Gonzalez-Neira A,Martin-Escudero JC,Benitez J,Lluch A,Chaves FJ,Eroles P

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, little is known about the prognostic relevance of the OPN mRNA splice variants. METHODS:We analyzed ...

journal_title：BMC cancer

authors： Hahnel A,Wichmann H,Greither T,Kappler M,Würl P,Kotzsch M,Taubert H,Vordermark D,Bache M

更新日期：2012-04-02 00:00:00

abstract：BACKGROUND:BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signaling pathways. Evidence that BAG-1 expression is frequently altered in human cancers, in particular in...

journal_title：BMC cancer

authors： Götz R,Kramer BW,Camarero G,Rapp UR

更新日期：2004-11-24 00:00:00