Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma.

abstract：BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...

journal_title：BMC cancer

authors： Lovitt CJ,Shelper TB,Avery VM

更新日期：2018-01-06 00:00:00

abstract：BACKGROUND:The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid instrument measuring satisfaction among patients with breast cancer and exploring their care itiner...

journal_title：BMC cancer

authors： Defossez G,Mathoulin-Pelissier S,Ingrand I,Gasquet I,Sifer-Riviere L,Ingrand P,Salamon R,Migeot V,REPERES research network.

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk of pathological fractures, and neurological deficits. The aim of this randomized, controlled pilot ...

journal_title：BMC cancer

authors： Rief H,Omlor G,Akbar M,Welzel T,Bruckner T,Rieken S,Haefner MF,Schlampp I,Gioules A,Habermehl D,von Nettelbladt F,Debus J

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA region) were identified in the 3p21.3 region. We have shown previously that homozygous deletions in A...

journal_title：BMC cancer

authors： Senchenko VN,Anedchenko EA,Kondratieva TT,Krasnov GS,Dmitriev AA,Zabarovska VI,Pavlova TV,Kashuba VI,Lerman MI,Zabarovsky ER

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed malignant and large, pancreatic paraganglioma with marked invasion. Also another unique feature was ...

journal_title：BMC cancer

authors： Al-Jiffry BO,Alnemary Y,Khayat SH,Haiba M,Hatem M

更新日期：2013-10-20 00:00:00

abstract：BACKGROUND:Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/...

journal_title：BMC cancer

authors： Sinilnikova OM,Dondon MG,Eon-Marchais S,Damiola F,Barjhoux L,Marcou M,Verny-Pierre C,Sornin V,Toulemonde L,Beauvallet J,Le Gal D,Mebirouk N,Belotti M,Caron O,Gauthier-Villars M,Coupier I,Buecher B,Lortholary A,Dugast

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been reported where it has significant correlation with the cancer cell proliferation. However, the functi...

journal_title：BMC cancer

authors： Lim S,Yoo BK,Kim HS,Gilmore HL,Lee Y,Lee HP,Kim SJ,Letterio J,Lee HG

更新日期：2014-12-10 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c. ...

journal_title：BMC cancer

authors： Nilsson G,Kannius-Janson M

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the mechanism of caspase-9 inhibition, with a focus on a possible rol...

journal_title：BMC cancer

authors： Checinska A,Giaccone G,Hoogeland BS,Ferreira CG,Rodriguez JA,Kruyt FA

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several signaling pathways, including NF-κB, are altered in TNBC, and the complexity of this disease implies ...

journal_title：BMC cancer

authors： House CD,Grajales V,Ozaki M,Jordan E,Wubneh H,Kimble DC,James JM,Kim MK,Annunziata CM

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target...

journal_title：BMC cancer

authors： Wu L,Blum W,Zhu CQ,Yun Z,Pecze L,Kohno M,Chan ML,Zhao Y,Felley-Bosco E,Schwaller B,de Perrot M

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. METHODS:We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several...

journal_title：BMC cancer

authors： Holmes MD,Olsson H,Pawitan Y,Holm J,Lundholm C,Andersson TM,Adami HO,Askling J,Smedby KE

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...

journal_title：BMC cancer

authors： Chen YH,Lu HI,Lo CM,Wang YM,Chou SY,Hsiao CC,Huang CC,Shih LH,Chen SW,Li SH

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherite...

journal_title：BMC cancer

authors： Neklason DW,Done MW,Sargent NR,Schwartz AG,Anton-Culver H,Griffin CA,Ahnen DJ,Schildkraut JM,Tomlinson GE,Strong LC,Miller AR,Stopfer JE,Burt RW

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent could be a promising approach to circumvent the limitations of previously attempted therapeutic inte...

journal_title：BMC cancer

authors： Xu J,Singh A,Amiji MM

更新日期：2014-02-08 00:00:00

abstract：BACKGROUND:The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with renal cell carcinoma (RCC). METHODS:EZH2 protein expression in RC...

journal_title：BMC cancer

authors： Wagener N,Macher-Goeppinger S,Pritsch M,Hüsing J,Hoppe-Seyler K,Schirmacher P,Pfitzenmaier J,Haferkamp A,Hoppe-Seyler F,Hohenfellner M

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...

journal_title：BMC cancer

authors： Ejegod DM,Rebolj M,Bonde J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Medical oncologists continue to use performance status as a proxy for quality of life (QOL) measures, as completion of QOL instruments is perceived as time consuming, may measure aspects of QOL not affected by cancer therapy, and interpretation may be unclear. The pulse oximeter is widely used in clinical pr...

journal_title：BMC cancer

authors： Martins SJ,Ho N,Cavamura SO,Harada CM,Yamamoto CA,Takagaki TY

更新日期：2005-07-06 00:00:00

abstract：BACKGROUND:Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In this study, which examined the value of serum TRAP concentrations as ...

journal_title：BMC cancer

authors： Honig A,Rieger L,Kapp M,Krockenberger M,Eck M,Dietl J,Kämmerer U

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS:The SHMT1 and MTHFR genotypes w...

journal_title：BMC cancer

authors： Komlósi V,Hitre E,Pap E,Adleff V,Réti A,Székely E,Bíró A,Rudnai P,Schoket B,Müller J,Tóth B,Ottó S,Kásler M,Kralovánszky J,Budai B

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publicatio...

journal_title：BMC cancer

authors： Wang L,Yu X,Li J,Zhang Z,Hou J,Li F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphom...

journal_title：BMC cancer

authors： Sernbo S,Gustavsson E,Brennan DJ,Gallagher WM,Rexhepaj E,Rydnert F,Jirström K,Borrebaeck CA,Ek S

更新日期：2011-09-24 00:00:00

abstract：BACKGROUND:Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. METHODS:Here we investigated genomic aberrations affecting genes of the intrinsic apop...

journal_title：BMC cancer

authors： Lamers F,Schild L,Koster J,Speleman F,Øra I,Westerhout EM,van Sluis P,Versteeg R,Caron HN,Molenaar JJ

更新日期：2012-07-12 00:00:00

abstract：BACKGROUND:CST6 promoter is highly methylated in cancer, and its detection can provide important prognostic information in breast cancer patients. The aim of our study was to develop a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation. METHODS:We ...

journal_title：BMC cancer

authors： Dimitrakopoulos L,Vorkas PA,Georgoulias V,Lianidou ES

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:The main aim of this study is to estimate the rate of false negative and true IC on the Program for the Early Detection of Breast Cancer (PEDBC) run by the Girona Health Region (GHR) and compare the clinicopathological characteristics of these tumors with those detected within the same program. METHODS:A re...

journal_title：BMC cancer

authors： Renart-Vicens G,Puig-Vives M,Albanell J,Castañer F,Ferrer J,Carreras M,Tarradas J,Sala M,Marcos-Gragera R

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...

journal_title：BMC cancer

authors： Zhang D,Chen X,Xia H,Wang L,Zhao H,Xu B,Zhang A,Zhang W

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...

journal_title：BMC cancer

authors： Wu C,Gupta N,Huang YH,Zhang HF,Alshareef A,Chow A,Lai R

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer. METHODS:A total of 301 consecutive patients (mean age, 49.8 ± 11.0 years; range, 29-86 years) with breast cancer confirmed by patho...

journal_title：BMC cancer

authors： Ni-Jia-Ti MY,Ai-Hai-Ti DL,Huo-Jia AS,Wu-Mai-Er PL,A-Bu-Li-Zi AB,Shi Y,Rou-Zi NE,Su WJ,Dai GZ,Da-Mo-la MH

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney cancer is rising across the sexes in some of these countries, a trend which may possibly reflect the ...

journal_title：BMC cancer

authors： López-Abente G,Aragonés N,Pérez-Gómez B,Ramis R,Vidal E,García-Pérez J,Fernández-Navarro P,Pollán M

更新日期：2008-10-09 00:00:00

abstract：BACKGROUND:While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients' quality of life. This study aimed to develop a treatment for inflammatory ulcers as one of the side effects of afat...

journal_title：BMC cancer

authors： Sano K,Nakadate K,Hanada K

更新日期：2020-04-06 00:00:00