Abstract:
BACKGROUND:The prognostic value of p53 protein expression in esophageal cancer has been evaluated, but the results remain inconclusive and no consensus has yet been achieved. This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in esophageal cancer. METHODS:Publications that assessed the clinical or prognostic significance of p53 expression in esophageal cancer and were published before July 1, 2015 were identified by searching the PubMed and EMBASE databases. A meta-analysis was performed to clarify the association between p53 expression and the clinical outcomes. RESULTS:A total of 36 publications met the criteria and included 4577 cases. Analysis of these data showed that p53 expression in esophageal cancer was significantly associated with poorer 5-year survival (RR = 1.30, 95 % CI: 1.11-1.51, P = 0.0008). Subgroup analyses according to histological type, continent of the patients, and cut-off value revealed the similar results. The results also indicated that p53 expression was highly associated with advanced TNM stages (I/II vs. III/IV, OR = 0.74, 95 % CI: 0.55-0.99, P = 0.04), lymph node metastasis (OR = 0.77, 95 % CI: 0.66-0.90, P = 0.001), and distant metastasis (OR = 0.46, 95 % CI: 0.26-0.80, P = 0.006). However, p53 expression in the included studies was not significantly associated with tumor size (≤ 5 cm vs. > 5 cm, OR = 1.13, 95 % CI: 0.92-1.40, P = 0.24), tumor location (upper + middle vs. lower, OR = 0.91, 95 % CI: 0.70-1.17, P = 0.45), grade of differentiation (well + moderate vs. poor, OR = 1.10, 95 % CI: 0.90-1.34, P = 0.35), and the depth of invasion (T1/T2 vs. T3/T4, OR = 0.86, 95 % CI: 0.71-1.03, P = 0.09). CONCLUSIONS:This meta-analysis showed that p53 expression may be a useful biomarker for predicting poorer prognosis in patients with esophageal cancer.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wang L,Yu X,Li J,Zhang Z,Hou J,Li Fdoi
10.1186/s12885-016-2427-6subject
Has Abstractpub_date
2016-07-01 00:00:00pages
373issn
1471-2407pii
10.1186/s12885-016-2427-6journal_volume
16pub_type
杂志文章,meta分析相关文献
BMC CANCER文献大全abstract:BACKGROUND:Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA (protein) Napsin A was described to promote resistance to cisplatin by degradation of the tumor sup...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-524
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor signaling cascades are kn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1363-1
更新日期:2015-05-08 00:00:00
abstract:BACKGROUND:18F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify 18F-FDG PET/CT findings that might differentiate AIP from PC. METHODS:FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3665-y
更新日期:2017-10-23 00:00:00
abstract:BACKGROUND:We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigration of cancer cells through e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6219-7
更新日期:2019-10-16 00:00:00
abstract:BACKGROUND:Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammogr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3010-x
更新日期:2017-01-10 00:00:00
abstract:BACKGROUND:Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer. METHODS:LTA polymorphisms C804A (rs1041981, T60N) and T495C (rs2229094, C13R) were determined in 1,536 consecutive autopsy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-235
更新日期:2008-08-13 00:00:00
abstract:BACKGROUND:Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and postoperative chemotherapy. However, these reg...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-018-4770-2
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:Young age remains a controversial issue as a prognostic factor in breast cancer. Debate includes patients from different parts of the world. Almost 50% of patients with breast cancer seen at the American University of Beirut Medical Center (AUBMC) are below age 50. METHODS:We reviewed 1320 patients seen at ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-194
更新日期:2006-07-20 00:00:00
abstract:BACKGROUND:The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC). METHODS:A systematic search of the MEDLINE, EMBASE, and Web of Science databas...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-6668-z
更新日期:2020-03-04 00:00:00
abstract::Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye us...
journal_title:BMC cancer
pub_type: 评论,杂志文章
doi:10.1186/s12885-017-3656-z
更新日期:2017-11-07 00:00:00
abstract:BACKGROUND:Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not been evaluated. This study examines the chronological changes of gut microbiota i...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6654-5
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer. METHODS:Using population-based data from the Korea Central Cancer Re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4530-3
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3806-3
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Resilience has been linked to psychological adaptation to many challenging life events. The present study aims to explore the level of resilience in oral cancer patients and the key factors associated with resilience, and to evaluate the relationship between resilience and anxiety. METHODS:A multiple center...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-019-5679-0
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells. METHODS:The growth inhibition of U251 cells induced by resveratrol was assessed with methyl thiazolyl tetrazoli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-215
更新日期:2009-06-30 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investigate the ability of EHD1 [Eps15 homology (EH) domain - containing protein 1] to confer CDDP resistanc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2527-3
更新日期:2016-07-13 00:00:00
abstract:BACKGROUND:Bone mineral density (BMD) and lean mass (LM) may both decrease in breast cancer survivors, thereby increasing risk of falls and fractures. Research is needed to determine whether lean mass (LM) and fat mass (FM) independently relate to BMD in this patient group. METHODS:The Health, Eating, Activity, and Li...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-497
更新日期:2013-10-25 00:00:00
abstract:BACKGROUND:Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based design, a novel compound, FLLL32, was generated from curcumin. FLLL32 possesses superior biochemical prop...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-112
更新日期:2011-03-28 00:00:00
abstract:BACKGROUND:The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, particularly in Asian melanoma. METHODS:We retrospectively reviewed 49 melanoma patients undergoing...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07508-7
更新日期:2020-10-21 00:00:00
abstract::Following publication of the original article [1], the authors reported the following error is the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-6367-9
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples fr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5348-3
更新日期:2019-02-12 00:00:00
abstract:BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-019-5760-8
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various cancers including pancreatic cancer. METHODS:We investigated the anti tumor efficacy of triptolide in ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4995-0
更新日期:2018-11-12 00:00:00
abstract::Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial distress. The increasing incidence of this disease, high cure rates, and significant long-term sequelae warran...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-6053-y
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism of action of ARC was further investigated by comparing in vitro and in vivo activity with other ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-63
更新日期:2009-02-20 00:00:00
abstract:BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07081-z
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-27
更新日期:2007-02-02 00:00:00
abstract:BACKGROUND:Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression of hepatocellular carcinoma. METHODS:In the present study, the e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3839-7
更新日期:2017-12-06 00:00:00
abstract:BACKGROUND:Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases risks of urinary and bowel toxicity. Recently the contribution of "spacers" positioned in the septum...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4492-5
更新日期:2018-05-16 00:00:00
abstract:BACKGROUND:We sought to determine the comparative diagnostic performance of standard b-value (800-1000 s/mm2) versus low b-value (400-500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC). METHOD:After a systematic review of the available literature, studies w...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-843
更新日期:2014-11-18 00:00:00