Abstract:
BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the classification tree multivariate method on a group of 849 first cancer survivors, to identify childhood cancer patients with the greatest risk for development of secondary neoplasms. RESULTS:In observed group of patients, 34 develop secondary neoplasm after treatment of primary cancer. Analysis of parameters present at the treatment of first cancer, exposed two groups of patients at the special risk for secondary neoplasm. First are female patients treated for Hodgkin's disease at the age between 10 and 15 years, whose treatment included radiotherapy. Second group at special risk were male patients with acute lymphoblastic leukemia who were treated at the age between 4.6 and 6.6 years of age. CONCLUSION:The risk groups identified in our study are similar to the results of studies that used more conventional approaches. Usefulness of our approach in study of occurrence of second neoplasms should be confirmed in larger sample study, but user friendly presentation of results makes it attractive for further studies.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Jazbec J,Todorovski L,Jereb Bdoi
10.1186/1471-2407-7-27subject
Has Abstractpub_date
2007-02-02 00:00:00pages
27issn
1471-2407pii
1471-2407-7-27journal_volume
7pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The aim of this study was to assess the feasibility and potential benefit of a brief psychosocial intervention based on cognitive-behavioral therapy performed in addition to early palliative care (PC) in the reduction of depressive symptoms among patients with advanced cancer. METHODS:An open-label randomiz...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-017-3560-6
更新日期:2017-08-23 00:00:00
abstract:BACKGROUND:CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and functional causality between CCR7 expression and lymph node metastasis in patients with esophageal squamous ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-291
更新日期:2014-04-26 00:00:00
abstract:BACKGROUND:Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-631
更新日期:2010-11-18 00:00:00
abstract:BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-124
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3029-z
更新日期:2017-01-11 00:00:00
abstract:BACKGROUND:The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts surviva...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-5
更新日期:2008-01-14 00:00:00
abstract:BACKGROUND:Estimating the risk of malignancy is essential in the management of adnexal masses. An accurate differential diagnosis between benign and malignant masses will reduce morbidity and costs due to unnecessary operations, and will improve referral to a gynecologic oncologist for specialized cancer care, which im...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-015-1319-5
更新日期:2015-06-26 00:00:00
abstract:BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-168
更新日期:2012-05-06 00:00:00
abstract:BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-365
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mortality. The Sept9 DNA-methylation assay is among the most well studied blood-based screening markers...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1832-6
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-333
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-357
更新日期:2011-08-17 00:00:00
abstract:BACKGROUND:A disintegrin and metalloprotease 8 (ADAM8) has been reported to be associated with various malignancies. However, no studies have examined ADAM8 association in colorectal cancer (CRC). The aim of this study was to investigate the expression and function of ADAM8 in CRC. METHODS:Expression level of ADAM8 in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-568
更新日期:2014-08-07 00:00:00
abstract:BACKGROUND:The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were to evaluate the needs in cancer inpatients and to improve the understanding of the meanings of the n...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-3-12
更新日期:2003-04-23 00:00:00
abstract:BACKGROUND:Platelets are frequently altered in hepatocellular carcinoma (HCC) patients. Platelet lysates (hPL) can enhance HCC cell growth and decrease apoptosis. The aims were to evaluate whether hPL can modulate the actions of sorafenib or regorafenib, two clinical HCC multikinase antagonists. METHODS:Several human ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-351
更新日期:2014-05-21 00:00:00
abstract:BACKGROUND:3,3'-diindolylmethane (DIM) is an acid-catalyzed dimer of idole-3-carbinol (I3C), a phytochemical found in cruciferous vegetables that include broccoli, Brussels sprouts and cabbage. DIM is an aryl hydrocarbon receptor (AhR) ligand and a potential anticancer agent, namely for the treatment of breast cancer. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-524
更新日期:2014-07-21 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) is one of the standard care regimens for patients with resectable early-stage breast cancer. It would be advantageous to determine the chemosensitivity of tumors before initiating NAC. One of the parameters potentially compromising such chemosensitivity would be a hypoxic micro...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-400
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4585-1
更新日期:2018-06-18 00:00:00
abstract:BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-71
更新日期:2008-03-10 00:00:00
abstract:BACKGROUND:The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attractive drug candidates for the targeted therapy of this malignancy. However, the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-337
更新日期:2008-11-17 00:00:00
abstract:BACKGROUND:The APC tumor suppressor is mutated or downregulated in many tumor types, and is prominently localized to punctate clusters at protrusion tips in migratory cells, such as in astrocytes where it has been implicated in directed cell motility. Although APC loss is considered an initiating event in colorectal ca...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-12
更新日期:2013-01-09 00:00:00
abstract:BACKGROUND:Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07761-w
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-5086-y
更新日期:2018-12-05 00:00:00
abstract:BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-612
更新日期:2010-11-08 00:00:00
abstract:BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07670-y
更新日期:2021-01-04 00:00:00
abstract:BACKGROUND:Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects rel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6661-6
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-138
更新日期:2013-03-21 00:00:00
abstract:BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were de...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-566
更新日期:2012-12-02 00:00:00
abstract:BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and relationship with survival in patients with PDAC to establish the significance of GOLPH3 in the dev...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-571
更新日期:2014-08-07 00:00:00
abstract:BACKGROUND:After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surveillance strategy has been proposed for SCC patients with clinically complete response (cCR) after nC...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12885-020-6669-y
更新日期:2020-03-06 00:00:00