Abstract:
BACKGROUND:After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surveillance strategy has been proposed for SCC patients with clinically complete response (cCR) after nCRT. To justify omitting surgical resection, patients with residual disease should be accurately identified. The aim of this study is to assess the accuracy of response evaluations after nCRT based on the preSANO trial, including positron emission tomography with computed tomography (PET-CT), endoscopy with bite-on-bite biopsies and endoscopic ultrasonography (EUS) with fine-needle aspiration (FNA) in patients with potentially curable esophageal SCC. METHODS:Operable esophageal SCC patients who are planned to undergo nCRT according to the CROSS regimen and are planned to undergo surgery will be recruited from four Asian centers. Four to 6 weeks after completion of nCRT, patients will undergo a first clinical response evaluation (CRE-1) consisting of endoscopy with bite-on-bite biopsies. In patients without histological evidence of residual tumor (i.e. without positive biopsies), surgery will be postponed another 6 weeks. A second clinical response evaluation (CRE-2) will be performed 10-12 weeks after completion of nCRT, consisting of PET-CT, endoscopy with bite-on-bite biopsies and EUS with FNA. Immediately after CRE-2 all patients without evidence of distant metastases will undergo esophagectomy. Results of CRE-1 and CRE-2 as well as results of the three single diagnostic modalities will be correlated to pathological response in the resection specimen (gold standard) for calculation of sensitivity, specificity, negative predictive value and positive predictive value. DISCUSSION:If the current study shows that major locoregional residual disease (> 10% residual carcinoma or any residual nodal disease) can be accurately (i.e. with sensitivity of 80.5%) detected in patients with esophageal SCC, a prospective trial will be conducted comparing active surveillance with standard esophagectomy in patients with a clinically complete response after nCRT (SINO trial). TRIAL REGISTRATION:The preSINO trial has been registered at ClinicalTrials.gov as NCT03937362 (May 3, 2019).
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Zhang X,Eyck BM,Yang Y,Liu J,Chao YK,Hou MM,Hung TM,Pang Q,Yu ZT,Jiang H,Law S,Wong I,Lam KO,van der Wilk BJ,van der Gaast A,Spaander MCW,Valkema R,Lagarde SM,Wijnhoven BPL,van Lanschot JJB,Li Zdoi
10.1186/s12885-020-6669-ysubject
Has Abstractpub_date
2020-03-06 00:00:00pages
194issue
1issn
1471-2407pii
10.1186/s12885-020-6669-yjournal_volume
20pub_type
临床试验,杂志文章,多中心研究相关文献
BMC CANCER文献大全abstract:BACKGROUND:The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3762-y
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3029-z
更新日期:2017-01-11 00:00:00
abstract:BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3412-4
更新日期:2017-06-19 00:00:00
abstract:BACKGROUND:Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-261
更新日期:2012-06-21 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovarian cancer (EOC). METHODS:Patients diagnosed with EOC during 2012-2015 were analyzed retrospectivel...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3476-1
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4300-2
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:We utilized miRNAs expression and clinical data to develop a prognostic signature for patients with lung adenocarcinoma, with respect to their overall survival, to identify high-risk subjects based on their miRNA genomic profile. METHODS:MiRNA expressions based on miRNA sequencing and clinical data of lung ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5206-8
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K ...
journal_title:BMC cancer
pub_type: 历史文章,杂志文章,评审
doi:10.1186/1471-2407-14-595
更新日期:2014-08-16 00:00:00
abstract:BACKGROUND:Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-405
更新日期:2010-08-04 00:00:00
abstract:BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07347-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07350-x
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-259
更新日期:2010-06-04 00:00:00
abstract:BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07676-6
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Traditional beliefs of androgen's stimulating effects on the growth of prostate cancer (PCa) have been challenged in recent years. Our previous in vitro study indicated that physiological normal levels of androgens inhibited the proliferation of PCa cells. In this in vivo study, the ability of testosterone (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3569-x
更新日期:2017-09-07 00:00:00
abstract:BACKGROUND:During the last two decades the use of laparoscopic resection and a multimodal approach known as an enhanced recovery programme, have been major changes in colorectal perioperative care. Clinical outcome improves using laparoscopic surgery to resect colorectal cancer but until recently no multicentre trial e...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-12-181
更新日期:2012-05-16 00:00:00
abstract:BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-365
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis. The arginine-lowering agent PEGylated arginine deiminase (ADI-PEG 20) has shown efficacy as a monot...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-621
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect varies substantially among ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-016-2859-z
更新日期:2016-11-03 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the severity of pain and its impact on the quality of life (QoL) in untreated patients with head and neck squamous cell carcinoma (HNSCC). METHODS:A study group of 127 patients with HNSCC were interviewed before antineoplastic treatment. The severity of pain was measured ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-39
更新日期:2014-01-24 00:00:00
abstract:BACKGROUND:To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use. METHODS:Pubmed and Embase were searched up the terms radiomics or radiogenomics and gliomas or glioblastomas until February 2019. From 189 articles, 51 ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-6504-5
更新日期:2020-01-10 00:00:00
abstract:BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1512-6
更新日期:2015-07-04 00:00:00
abstract:BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-34
更新日期:2002-12-03 00:00:00
abstract:BACKGROUND:Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physician factors impact treatment decisions. The purpose of this study was to examine patient and physic...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07355-6
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:Stimulation of vascular endothelial growth factor (VEGF) has been observed following transarterial chemoembolization (TACE) in hepatocellular cancer (HCC) and may contribute to tumor regrowth. This pilot study examined whether intravenous (IV) bevacizumab, a monoclonal antibody against VEGF, could inhibit ne...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-12-16
更新日期:2012-01-14 00:00:00
abstract:BACKGROUND:The origin and development of breast cancer remain complex and obscure. Recently, microRNA (miRNA) has been identified as an important regulator of the initiation and progression of breast cancer, and some studies have shown the essential role of miR-124-3p as a tumor suppressor in breast tumorigenesis. Howe...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2862-4
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in triple-negative breast cancer (TNBC) and their predictive role in determining the patient's outcome are u...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1151-y
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has not been ex...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1011-9
更新日期:2015-01-23 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a type of head-neck cancer with a distinguishable geographic and racial distribution worldwide. Increasing evidence supports that the accumulation of additional genetic and epigenetic abnormalities is important in driving the NPC tumorigenic process. In this study, we aim to...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2714-2
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a downstram molecule of the pathway, in predicting chemotherapy response in breast cancer. METHODS:The...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-585
更新日期:2012-12-10 00:00:00
abstract:BACKGROUND:The number of circulating tumor cells (CTCs) in metastatic prostate cancer patients provides prognostic and predictive information. However, it is the molecular characterization of CTCs that offers insight into the biology of these tumor cells in the context of personalized treatment. METHODS:We developed a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-78
更新日期:2012-02-28 00:00:00