The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies.

abstract：BACKGROUND:The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, particularly in Asian melanoma. METHODS:We retrospectively reviewed 49 melanoma patients undergoing...

journal_title：BMC cancer

authors： Wu CE,Yang CK,Peng MT,Huang PW,Chang CF,Yeh KY,Chen CB,Wang CL,Hsu CW,Chen IW,Lin CT,Ueng SH,Lin G,Lin YF,Cheng CY,Chang JW

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib is used for mRCC chemotherapy based on the favorable results of a recent clinical trial, but specifi...

journal_title：BMC cancer

authors： Takayoshi K,Sagara K,Uchino K,Kusaba H,Sakamoto N,Iguchi A,Baba E

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...

journal_title：BMC cancer

authors： Bischel LL,Beebe DJ,Sung KE

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompted us to assess the diagnostic usefulness of these MMPs and the Tissue Inhibitor of Metalloproteinase...

journal_title：BMC cancer

authors： Blanco-Prieto S,Barcia-Castro L,Páez de la Cadena M,Rodríguez-Berrocal FJ,Vázquez-Iglesias L,Botana-Rial MI,Fernández-Villar A,De Chiara L

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from clinical trials investigating immunotherapies in metastatic melanoma. Since information on pre-existi...

journal_title：BMC cancer

authors： Ma Q,Shilkrut M,Zhao Z,Li M,Batty N,Barber B

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor that contributes to tumour aggressiveness and correlates with poor prognosis and resistance to conventional therapy. Therefore, identifying hypoxic environments within tumours is extremely useful for understanding cancer biology and developing novel therapeutic strategies. Seve...

journal_title：BMC cancer

authors： Takei N,Yoneda A,Kosaka M,Sakai-Sawada K,Tamura Y

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism is not fully elucidate...

journal_title：BMC cancer

authors： Sato Y,Kubo T,Morimoto K,Yanagihara K,Seyama T

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell surv...

journal_title：BMC cancer

authors： Koschny R,Brost S,Hinz U,Sykora J,Batke EM,Singer S,Breuhahn K,Stremmel W,Walczak H,Schemmer P,Schirmacher P,Ganten TM

更新日期：2013-11-09 00:00:00

abstract：BACKGROUND:Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mitogenic and angiogenic factor, which is expressed at an increased level in human prostate tumours an...

journal_title：BMC cancer

authors： Tuomela J,Grönroos TJ,Valta MP,Sandholm J,Schrey A,Seppänen J,Marjamäki P,Forsback S,Kinnunen I,Solin O,Minn H,Härkönen PL

更新日期：2010-10-30 00:00:00

abstract：BACKGROUND:Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to ...

journal_title：BMC cancer

authors： Thumallapally N,Meshref A,Mousa M,Terjanian T

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:To evaluate the effect of Recurrence Score® results (RS; Oncotype DX® multigene assay ODX) on treatment recommendations by Swiss multidisciplinary tumor boards (TB). METHODS:SAKK 26/10 is a multicenter, prospective cohort study of early breast cancer patients: Eligibility: R0-resection, ≥10% ER+ malignant c...

journal_title：BMC cancer

authors： Pestalozzi BC,Tausch C,Dedes KJ,Rochlitz C,Zimmermann S,von Moos R,Winterhalder R,Ruhstaller T,Mueller A,Buser K,Borner M,Novak U,Nussbaum CU,Seifert B,Bigler M,Bize V,Vilei SB,Rageth C,Aebi S,Swiss Group for Clinic

更新日期：2017-04-13 00:00:00

abstract：BACKGROUND:Angiogenesis is a proliferative process resulting in the development of new blood vessels from existing endothelial cells and is considered crucial for tumor growth and metastasis. Tumor angiogenesis can be quantified by microvascular density (MVD), which is evaluated in highly vascularized tumor areas (hot ...

journal_title：BMC cancer

authors： Paschoal JP,Bernardo V,Canedo NH,Ribeiro OD,Caroli-Bottino A,Pannain VL

更新日期：2014-02-07 00:00:00

abstract：BACKGROUND:Oxidative stress is a widely seen phenomenon in several carcinomas. Increasing evidence also suggests that it has a significant role in the development of epithelial ovarian carcinoma (EOC). 8-Hydroxydeoxyguanosine (8-OHdG) is one of the main indicators of oxidative stress and increased expression of 8-OHdG ...

journal_title：BMC cancer

authors： Pylväs-Eerola M,Karihtala P,Puistola U

更新日期：2015-07-02 00:00:00

abstract：BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...

journal_title：BMC cancer

authors： Havre PA,Dang LH,Ohnuma K,Iwata S,Morimoto C,Dang NH

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment. METHODS:We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionn...

journal_title：BMC cancer

authors： Yun YH,Kim YA,Sim JA,Shin AS,Chang YJ,Lee J,Kim MS,Shim YM,Zo JL

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Socioeconomic inequalities in cancer mortality in Britain have been shown to be present in the 1990s and early 2000s. Little is known about on-going patterns in such inequalities in cancer mortality. We examined time trends in socioeconomic inequalities in cancer mortality in Britain between 1978 and 2013. ...

journal_title：BMC cancer

authors： Ramsay SE,Morris RW,Whincup PH,Papacosta AO,Lennon LT,Wannamethee SG

更新日期：2014-06-30 00:00:00

abstract：BACKGROUND:Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of primary PMHE in which denosumab treatment showed activity in both imaging studies and the clinical ou...

journal_title：BMC cancer

authors： Otani S,Nakayama R,Sekita T,Hirozane T,Asano N,Nishimoto K,Sasaki A,Okita H,Morioka H,Nakamura M,Matsumoto M

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:In Australia, associations between geographic remoteness, socioeconomic disadvantage, and colorectal cancer (CRC) survival show that survival rates are lowest among residents of geographically remote regions and those living in disadvantaged areas. At present we know very little about the reasons for these i...

journal_title：BMC cancer

authors： Baade PD,Turrell G,Aitken JF

更新日期：2010-01-28 00:00:00

abstract：BACKGROUND:The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA region) were identified in the 3p21.3 region. We have shown previously that homozygous deletions in A...

journal_title：BMC cancer

authors： Senchenko VN,Anedchenko EA,Kondratieva TT,Krasnov GS,Dmitriev AA,Zabarovska VI,Pavlova TV,Kashuba VI,Lerman MI,Zabarovsky ER

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make compliance with protocol-driven treatment challenging in low- and...

journal_title：BMC cancer

authors： Vasudevan L,Schroeder K,Raveendran Y,Goel K,Makarushka C,Masalu N,Zullig LL

更新日期：2020-03-29 00:00:00

abstract：BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...

journal_title：BMC cancer

authors： Stavik B,Skretting G,Aasheim HC,Tinholt M,Zernichow L,Sletten M,Sandset PM,Iversen N

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second ...

journal_title：BMC cancer

authors： Brasseur M,Heurgué-Berlot A,Barbe C,Brami C,Rey JB,Vella-Boucaud J,Dabouz F,Deslée G,Grange F,Volet J,Bouché O

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...

journal_title：BMC cancer

authors： Lichthardt S,Wagner J,Löb S,Matthes N,Kastner C,Anger F,Germer CT,Wiegering A

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Prostate cancer is the single most prevalent cancer in US men whose gold standard of diagnosis is histologic assessment of biopsies. Manual assessment of stained tissue of all biopsies limits speed and accuracy in clinical practice and research of prostate cancer diagnosis. We sought to develop a fully-autom...

journal_title：BMC cancer

authors： Kwak JT,Hewitt SM,Sinha S,Bhargava R

更新日期：2011-02-09 00:00:00

abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...

journal_title：BMC cancer

authors： Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JH

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, particularly in health promotion and prevention. There are no randomized controlled trials in Latin ...

journal_title：BMC cancer

authors： Momany MC,Martinez-Gutierrez J,Soto M,Capurro D,Ciampi F,Thompson B,Puschel K

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Human studies of dietary fat as a possible risk factor for cutaneous malignant melanoma (CMM) and non-melanoma skin cancer (NMSC)--principally basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)--have produced inconsistent results. We had the opportunity to examine the association concurrently for a...

journal_title：BMC cancer

authors： Granger RH,Blizzard L,Fryer JL,Dwyer T

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic revi...

journal_title：BMC cancer

authors： Abogunrin S,Di Tanna GL,Keeping S,Carroll S,Iheanacho I

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In present study, we explored the mechanism of how TG2 may be involved in cell migration. METHODS:To study t...

journal_title：BMC cancer

authors： Kumar A,Hu J,LaVoie HA,Walsh KB,DiPette DJ,Singh US

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism of action of ARC was further investigated by comparing in vitro and in vivo activity with other ...

journal_title：BMC cancer

authors： Stockwin LH,Yu SX,Stotler H,Hollingshead MG,Newton DL

更新日期：2009-02-20 00:00:00