Preoperative serum 8-hydroxydeoxyguanosine is associated with chemoresistance and is a powerful prognostic factor in endometrioid-type epithelial ovarian cancer.

abstract：BACKGROUND:Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor-specific manner. Rec...

journal_title：BMC cancer

authors： Martirosyan A,Clendening JW,Goard CA,Penn LZ

更新日期：2010-03-18 00:00:00

abstract：BACKGROUND:Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal and tumor cells. These proteins appear to have a key role in the tumor microenvironment for cancer development and metastasis. There is little information regarding the prognostic value of the combination of ...

journal_title：BMC cancer

authors： Rouanne M,Adam J,Goubar A,Robin A,Ohana C,Louvet E,Cormier J,Mercier O,Dorfmüller P,Fattal S,de Montpreville VT,Lebret T,Dartevelle P,Fadel E,Besse B,Olaussen KA,Auclair C,Soria JC

更新日期：2016-07-15 00:00:00

abstract：BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...

journal_title：BMC cancer

authors： Morita M,Tamiya M,Fujimoto D,Tamiya A,Suzuki H,Hirano K,Fukuda Y,Yokoyama T,Kominami R,Kanazu M,Uchida J,Hara S,Yamashita S,Tomioka H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component. CASE PRESENTATION:A 47-year-old woman presented with left breas...

journal_title：BMC cancer

authors： Jeong YJ,Bong JG,Oh HK,Park SH,Kang SM,Bae SH

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Pelvic inflammatory disease (PID) is characterized by infection and inflammation of the upper genital tract in women and is associated with health sequelae. We used a nationwide population-based retrospective cohort study to explore the relationship between PID and the subsequent development of gynecological...

journal_title：BMC cancer

authors： Shen CC,Hu LY,Yang AC,Chiang YY,Hung JH,Tsai SJ

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/F...

journal_title：BMC cancer

authors： Jiang K,Li Y,Zhu Q,Xu J,Wang Y,Deng W,Liu Q,Zhang G,Meng S

更新日期：2014-07-30 00:00:00

abstract：BACKGROUND:Extrahepatic biliary duct cancers (EBDC) are uncommon malignancies characterized by a poor prognosis with high rate of loco-regional recurrence. The purpose of the present study is to assess the feasibility and the potential impact of adjuvant radiotherapy (RT) in a series of patients treated in one institut...

journal_title：BMC cancer

authors： Bonet Beltrán M,Roth AD,Mentha G,Allal AS

更新日期：2011-06-24 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OSA) still demands further investigation. This study aimed at probing into the function of hsa_circ_00...

journal_title：BMC cancer

authors： Li H,He L,Tuo Y,Huang Y,Qian B

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between...

journal_title：BMC cancer

authors： Kim Y,Franke AA,Shvetsov YB,Wilkens LR,Cooney RV,Lurie G,Maskarinec G,Hernandez BY,Le Marchand L,Henderson BE,Kolonel LN,Goodman MT

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:The use of high-dose chemotherapy combined with autologous stem cell transplantation has improved the outcome of hematologic malignancies. Nevertheless, this treatment can cause persistent fatigue and a reduced global quality of life, role and physical function. Physical exercise interventions may be benefic...

journal_title：BMC cancer

authors： Persoon S,Kersten MJ,Chinapaw MJ,Buffart LM,Burghout H,Schep G,Brug J,Nollet F

更新日期：2010-12-06 00:00:00

abstract：BACKGROUND:Resistance to 5-fluorouracil (5-FU) in patients with colorectal cancer prevents effective treatment and leads to unnecessary and burdensome chemotherapy. Therefore, prediction of 5-FU resistance is imperative. METHODS:To identify the proteins linked to 5-FU resistance, two-dimensional gel electrophoresis-ba...

journal_title：BMC cancer

authors： Park JW,Kim SC,Kim WK,Hong JP,Kim KH,Yeo HY,Lee JY,Kim MS,Kim JH,Yang SY,Kim DY,Oh JH,Cho JY,Yoo BC

更新日期：2014-03-06 00:00:00

abstract：BACKGROUND:Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and ...

journal_title：BMC cancer

authors： Plummer HK 3rd,Dhar MS,Cekanova M,Schuller HM

更新日期：2005-08-18 00:00:00

abstract：BACKGROUND:The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations. This study investigated genomic differences betwee...

journal_title：BMC cancer

authors： Mealey NE,O'Sullivan DE,Pader J,Ruan Y,Wang E,Quan ML,Brenner DR

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody used in association with chemotherapy in met...

journal_title：BMC cancer

authors： Lereclus E,Tout M,Girault A,Baroukh N,Caulet M,Borg C,Bouché O,Ternant D,Paintaud G,Lecomte T,Raoul W

更新日期：2017-03-27 00:00:00

abstract：BACKGROUND:Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were...

journal_title：BMC cancer

authors： Mizoo T,Taira N,Nishiyama K,Nogami T,Iwamoto T,Motoki T,Shien T,Matsuoka J,Doihara H,Ishihara S,Kawai H,Kawasaki K,Ishibe Y,Ogasawara Y,Komoike Y,Miyoshi S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...

journal_title：BMC cancer

authors： Hsieh CY,Lein MY,Yang SN,Wang YC,Lin YJ,Lin CY,Hua CH,Tsai MH,Lin CC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Mammographic breast density and parenchymal patterns are well-established risk factors for breast cancer. We aimed to report inter-observer agreement on three different subjective ways of assessing mammographic density and parenchymal pattern, and secondarily to examine what potential impact reproducibility ...

journal_title：BMC cancer

authors： Winkel RR,von Euler-Chelpin M,Nielsen M,Diao P,Nielsen MB,Uldall WY,Vejborg I

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...

journal_title：BMC cancer

authors： Shibata MA,Morimoto J,Shibata E,Kurose H,Akamatsu K,Li ZL,Kusakabe M,Ohmichi M,Otsuki Y

更新日期：2010-10-19 00:00:00

abstract：BACKGROUND:About 5-10% of breast cancer is due to inherited disease predisposition. Many previously identified susceptibility factors are involved in the maintenance of genomic integrity. AATF plays an important role in the regulation of gene transcription and cell proliferation. It induces apoptosis by associating wit...

journal_title：BMC cancer

authors： Haanpää M,Reiman M,Nikkilä J,Erkko H,Pylkäs K,Winqvist R

更新日期：2009-12-21 00:00:00

abstract：BACKGROUND:Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors, notably ASF/SF2. The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in ...

journal_title：BMC cancer

authors： Boukakis G,Patrinou-Georgoula M,Lekarakou M,Valavanis C,Guialis A

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-oral carbohydrate load and their influence on tumor characteristics and survival. METHODS:The study...

journal_title：BMC cancer

authors： Lende TH,Austdal M,Bathen TF,Varhaugvik AE,Skaland I,Gudlaugsson E,Egeland NG,Lunde S,Akslen LA,Jonsdottir K,Janssen EAM,Søiland H,Baak JPA

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:The increasing number of individuals living with cancer has led to a focus on the quality of life of survivors, and their families. Sexual wellbeing is a central component of quality of life, with a growing body of research demonstrating the association between cancer and changes to sexuality and intimacy. H...

journal_title：BMC cancer

authors： Perz J,Ussher JM,Gilbert E

更新日期：2013-05-31 00:00:00

abstract：BACKGROUND:The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported. METHODS:RT-PCR, western blotting and immunohistochemical techniques were used to examine EphB4 expression and pro...

journal_title：BMC cancer

authors： Lee YC,Perren JR,Douglas EL,Raynor MP,Bartley MA,Bardy PG,Stephenson SA

更新日期：2005-09-20 00:00:00

abstract：BACKGROUND:It is urgent to find some biochemical markers for predicting the radiochemotherapy sensitivity. microRNAs have a huge potential as a predictive biomarker in gastric cancer. The current study aims to identify the microRNAs related to the radiochemotherapy sensitivity in gastric cancer. METHODS:From April 201...

journal_title：BMC cancer

authors： Liu X,Cai H,Sheng W,Huang H,Long Z,Wang Y

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to deve...

journal_title：BMC cancer

authors： Luo J,Liu P,Wang L,Huang Y,Wang Y,Geng W,Chen D,Bai Y,Yang Z

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) are detectable in peripheral blood of metastatic breast cancer patients (MBC). In this paper we evaluate a new CTC separation method based on a combination of anti-EpCAM- and anti-cytokeratin magnetic cell separation with the aim to improve CTC detection with low target antigen...

journal_title：BMC cancer

authors： Weissenstein U,Schumann A,Reif M,Link S,Toffol-Schmidt UD,Heusser P

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially young patients. The flatness filter has been described as main source of photon scatter. MATERIAL ...

journal_title：BMC cancer

authors： Treutwein M,Steger F,Loeschel R,Koelbl O,Dobler B

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification of responsive patients before the chemotherapy is initiated. We have demonstrated that doxorubicin ...

journal_title：BMC cancer

authors： Denard B,Jiang S,Peng Y,Ye J

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluate...

journal_title：BMC cancer

authors： Wu Y,Ye S,Goswami S,Pei X,Xiang L,Zhang X,Yang H

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:This study was performed to design a predictive tool that allows the estimation of overall survival (OS) of elderly myeloma patients (aged ≥ 65 years) presenting with myeloma-induced spinal cord compression (SCC). METHODS:One-hundred-and-sixteen patients irradiated for motor deficits of the legs due to myel...

journal_title：BMC cancer

authors： Rades D,Conde-Moreno AJ,Cacicedo J,Veninga T,Gebauer N,Bartscht T,Schild SE

更新日期：2016-04-25 00:00:00