Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.

abstract：BACKGROUND:BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. METHODS:Here, additi...

journal_title：BMC cancer

authors： Bacopulos S,Amemiya Y,Yang W,Zubovits J,Burger A,Yaffe M,Seth AK

更新日期：2012-02-08 00:00:00

abstract：BACKGROUND:Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resi...

journal_title：BMC cancer

authors： He D,Xu Q,Yan M,Zhang P,Zhou X,Zhang Z,Duan W,Zhong L,Ye D,Chen W

更新日期：2009-09-25 00:00:00

abstract：BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...

journal_title：BMC cancer

authors： Hjortland GO,Meza-Zepeda LA,Beiske K,Ree AH,Tveito S,Hoifodt H,Bohler PJ,Hole KH,Myklebost O,Fodstad O,Smeland S,Hovig E

更新日期：2011-10-20 00:00:00

abstract：BACKGROUND:The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly focused on their gene expressions. The activation and function of the RTKs in ccRCC have not been full...

journal_title：BMC cancer

authors： Zhang Q,Liu JH,Liu JL,Qi CT,Yan L,Chen Y,Yu Q

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown. METHODS:We retrieved the expression data of 1168 CRC patients from 3 Gene Expression Omnibus (GEO)...

journal_title：BMC cancer

authors： Wang X,Yu Q,Ghareeb WM,Zhang Y,Lu X,Huang Y,Huang S,Sun Y,Lin J,Liu J,Chi P

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death and upregulation of 78-kDa glucose-regulated protein (GRP78). We hypothesized that chemotherapy induc...

journal_title：BMC cancer

authors： Raiter A,Lipovetzki J,Lubin I,Yerushalmi R

更新日期：2020-04-19 00:00:00

abstract：BACKGROUND:Gynecologic cancer is one of the most common malignant diseases in working-age women. This study investigated whether several characteristics influence return to work after treatment of gynecologic cancer. METHODS:We investigated the correlations between return to work and several other characteristics in 1...

journal_title：BMC cancer

authors： Nakamura K,Masuyama H,Nishida T,Haraga J,Ida N,Saijo M,Haruma T,Kusumoto T,Seki N,Hiramatsu Y

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer...

journal_title：BMC cancer

authors： Wang R,Chen S,Li C,Ng KT,Kong CW,Cheng J,Cheng SH,Li RA,Lo CM,Man K,Sun D

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. METHODS:Taiwan Cancer Registry records of 9039 subjects diagnos...

journal_title：BMC cancer

authors： Chen PH,Shieh TY,Ho PS,Tsai CC,Yang YH,Lin YC,Ko MS,Tsai PC,Chiang SL,Tu HP,Ko YC

更新日期：2007-06-15 00:00:00

abstract：BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...

journal_title：BMC cancer

authors： Allen-Brady K,Camp NJ

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...

journal_title：BMC cancer

authors： Ordás J,Millán Y,Dios R,Reymundo C,de Las Mulas JM

更新日期：2007-09-20 00:00:00

abstract：BACKGROUND:In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS:This is a cross...

journal_title：BMC cancer

authors： Saka B,Akakpo SA,Teclessou JN,Gnossike P,Adam S,Mahamadou G,Kassang P,Elegbede Y,Mouhari-Toure A,Darre T,Kombate K,Pitché P

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:To determine the effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy. METHODS:PubMed, Web of Science, ProQuest and Medline were searched using the key words "cervical cancer", "locally advanced disease", "radiotherapy" and "surgery ...

journal_title：BMC cancer

authors： Shi D,Liang Z,Zhang C,Zhang H,Liu X

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...

journal_title：BMC cancer

authors： Matsumoto M,Seike M,Noro R,Soeno C,Sugano T,Takeuchi S,Miyanaga A,Kitamura K,Kubota K,Gemma A

更新日期：2015-04-09 00:00:00

abstract：BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin ...

journal_title：BMC cancer

authors： Bifulco G,Mandato VD,Piccoli R,Giampaolino P,Mignogna C,Mignogna MD,Costagliola L,Nappi C

更新日期：2010-06-23 00:00:00

abstract：BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...

journal_title：BMC cancer

authors： Yu L,Wang H,Milijkovic D,Huang X,Jiang Q

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. Due to the high frequency of breast cancer in LFS/LFL families, these...

journal_title：BMC cancer

authors： Silva AG,Ewald IP,Sapienza M,Pinheiro M,Peixoto A,de Nóbrega AF,Carraro DM,Teixeira MR,Ashton-Prolla P,Achatz MI,Rosenberg C,Krepischi AC

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...

journal_title：BMC cancer

authors： Zhou P,Wang C,Hu Z,Chen W,Qi W,Li A

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, metastasis, and angioge...

journal_title：BMC cancer

authors： Chang AY,Wang M

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Subsyndromal delirium, a condition in which patients exhibit some, but not all, of the symptoms of delirium, can negatively affect the outcomes of patients with cancer. However, the incidence of subsyndromal delirium in patients with gastric cancer is unknown. Here, we investigated the incidence and risk fac...

journal_title：BMC cancer

authors： Hwang H,Lee KM,Son KL,Jung D,Kim WH,Lee JY,Kong SH,Suh YS,Lee HJ,Yang HK,Hahm BJ

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:This study aimed to identify potential predictive factors for the survival of advanced non small-cell lung cancer (NSCLC) patients undergoing first-line platinum-based chemotherapy. METHODS:A total of 270 advanced NSCLC patients who underwent first-line platinum-based chemotherapy from June, 2011 to June, 2...

journal_title：BMC cancer

authors： Ying J,Zhou D,Gu T,Huang J,Liu H

更新日期：2019-03-29 00:00:00

abstract：BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...

journal_title：BMC cancer

authors： Fiteni F,Ray IL,Ousmen A,Isambert N,Anota A,Bonnetain F

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α), transcriptional regulators of several genes involved in...

journal_title：BMC cancer

authors： Chintala S,Najrana T,Toth K,Cao S,Durrani FA,Pili R,Rustum YM

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservat...

journal_title：BMC cancer

authors： Gu B,Fang Q,Wu Y,Du W,Zhang X,Chen D

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...

journal_title：BMC cancer

authors： Lu R,Wu C,Guo L,Liu Y,Mo W,Wang H,Ding J,Wong ET,Yu M

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate cancer carcinogenesis is increasingly evident. In this study, the focus will be on histone modifica...

journal_title：BMC cancer

authors： Ngollo M,Lebert A,Dagdemir A,Judes G,Karsli-Ceppioglu S,Daures M,Kemeny JL,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon D

更新日期：2014-12-23 00:00:00

abstract：BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...

journal_title：BMC cancer

authors： Jassim GA,Whitford DL

更新日期：2013-04-28 00:00:00

abstract：BACKGROUND:Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the outcomes of current approaches necessitate an ongoing evaluation of the epidemiology and mortality-tre...

journal_title：BMC cancer

authors： Saad AM,Turk T,Al-Husseini MJ,Abdel-Rahman O

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In present study, we explored the mechanism of how TG2 may be involved in cell migration. METHODS:To study t...

journal_title：BMC cancer

authors： Kumar A,Hu J,LaVoie HA,Walsh KB,DiPette DJ,Singh US

更新日期：2014-04-11 00:00:00