The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo.

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is one of the most aggressive types of cancer. However, resistance to cisplatin (CDDP) remains a major challenge in NSCLC treatment. The purpose of this study was to investigate the ability of EHD1 [Eps15 homology (EH) domain - containing protein 1] to confer CDDP resistanc...

journal_title：BMC cancer

authors： Gao J,Meng Q,Zhao Y,Chen X,Cai L

更新日期：2016-07-13 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Oncology and the National Comprehensive Cancer Network based on the results from randomized controlled studies. H...

journal_title：BMC cancer

authors： Sureda A,André M,Borchmann P,da Silva MG,Gisselbrecht C,Vassilakopoulos TP,Zinzani PL,Walewski J

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:Resistance to 5-fluorouracil (5-FU) in patients with colorectal cancer prevents effective treatment and leads to unnecessary and burdensome chemotherapy. Therefore, prediction of 5-FU resistance is imperative. METHODS:To identify the proteins linked to 5-FU resistance, two-dimensional gel electrophoresis-ba...

journal_title：BMC cancer

authors： Park JW,Kim SC,Kim WK,Hong JP,Kim KH,Yeo HY,Lee JY,Kim MS,Kim JH,Yang SY,Kim DY,Oh JH,Cho JY,Yoo BC

更新日期：2014-03-06 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia a...

journal_title：BMC cancer

authors： Schilling D,Bayer C,Geurts-Moespot A,Sweep FC,Pruschy M,Mengele K,Sprague LD,Molls M

更新日期：2007-07-30 00:00:00

abstract：BACKGROUND:Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS:The SHMT1 and MTHFR genotypes w...

journal_title：BMC cancer

authors： Komlósi V,Hitre E,Pap E,Adleff V,Réti A,Székely E,Bíró A,Rudnai P,Schoket B,Müller J,Tóth B,Ottó S,Kásler M,Kralovánszky J,Budai B

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epi...

journal_title：BMC cancer

authors： Skiriute D,Vaitkiene P,Saferis V,Asmoniene V,Skauminas K,Deltuva VP,Tamasauskas A

更新日期：2012-06-06 00:00:00

abstract：BACKGROUND:Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. METHODS:Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and B...

journal_title：BMC cancer

authors： Zhou Y,Yau C,Gray JW,Chew K,Dairkee SH,Moore DH,Eppenberger U,Eppenberger-Castori S,Benz CC

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...

journal_title：BMC cancer

authors： Havre PA,Dang LH,Ohnuma K,Iwata S,Morimoto C,Dang NH

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood. METHODS:Expression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological character...

journal_title：BMC cancer

authors： An Y,Wang S,Li S,Zhang L,Wang D,Wang H,Zhu S,Zhu W,Li Y,Chen W,Ji S,Guo X

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Breast cancer incidence varies between social groups, but differences have not been thoroughly examined in New Zealand. The objectives of this study are to determine whether trends in breast cancer incidence varied by ethnicity and socioeconomic position between 1981 and 2004 in New Zealand, and to assess po...

journal_title：BMC cancer

authors： Cunningham R,Shaw C,Blakely T,Atkinson J,Sarfati D

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemot...

journal_title：BMC cancer

authors： Kim B,Stephen SL,Hanby AM,Horgan K,Perry SL,Richardson J,Roundhill EA,Valleley EM,Verghese ET,Williams BJ,Thorne JL,Hughes TA

更新日期：2015-09-11 00:00:00

abstract：BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...

journal_title：BMC cancer

authors： Tanimoto K,Sekiguchi N,Yokota Y,Kaneko A,Watanabe T,Maeshima AM,Matsuno Y,Harada M,Tobinai K,Kobayashi Y

更新日期：2006-10-20 00:00:00

abstract：BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...

journal_title：BMC cancer

authors： Netland IA,Førde HE,Sleire L,Leiss L,Rahman MA,Skeie BS,Gjerde CH,Enger PØ,Goplen D

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear. METHODS:We investigated the biological and clinical significance of the presence of KIT exon 10 variant (c.1621 A > C), KIT (L541), in a transfected cell lin...

journal_title：BMC cancer

authors： Brahmi M,Alberti L,Dufresne A,Ray-Coquard I,Cassier P,Meeus P,Decouvelaere AV,Ranchère-Vince D,Blay JY

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Survival rates for upper gastrointestinal (GI) cancer are poor since many are diagnosed at advanced stages. Fast track endoscopy has been introduced to prompt diagnosis for patients with alarm symptoms that could be indicative of upper GI cancer. However, these symptoms may represent benign conditions and li...

journal_title：BMC cancer

authors： Rasmussen S,Haastrup PF,Balasubramaniam K,Christensen RD,Søndergaard J,Jarbøl DE

更新日期：2018-04-18 00:00:00

abstract：BACKGROUND:Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer p...

journal_title：BMC cancer

authors： Vidlickova I,Dequiedt F,Jelenska L,Sedlakova O,Pastorek M,Stuchlik S,Pastorek J,Zatovicova M,Pastorekova S

更新日期：2016-03-19 00:00:00

abstract：BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...

journal_title：BMC cancer

authors： Hsieh CY,Lein MY,Yang SN,Wang YC,Lin YJ,Lin CY,Hua CH,Tsai MH,Lin CC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that...

journal_title：BMC cancer

authors： Hayashi T,Yamashita T,Terashima T,Suda T,Okada H,Asahina Y,Hayashi T,Hara Y,Nio K,Sunagozaka H,Takatori H,Arai K,Sakai Y,Yamashita T,Mizukoshi E,Honda M,Kaneko S

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...

journal_title：BMC cancer

authors： Wang S,Zheng Z,Chen P,Wu M

更新日期：2019-02-07 00:00:00

abstract：BACKGROUND:Splenic marginal zone lymphoma (SMZL) is a rare lymphoid B-cell malignant neoplasm with primary involvement of the spleen. It is a chronic disease, of indolent behavior and prolonged survival. However, 25% of cases have higher biological aggressiveness, propensity for histological transformation to high grad...

journal_title：BMC cancer

authors： de Pádua Covas Lage LA,Dos Santos FFC,Levy D,Moreira FR,Couto SCF,Culler HF,de Oliveira Costa R,Rocha V,Pereira J

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic disease who might benefit from adjuvant therapies. The aim was to examine if cellular immune markers...

journal_title：BMC cancer

authors： Falkenius J,Johansson H,Tuominen R,Frostvik Stolt M,Hansson J,Egyhazi Brage S

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The p...

journal_title：BMC cancer

authors： Wang W,Li J,Zhu W,Gao C,Jiang R,Li W,Hu Q,Zhang B

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear. METHODS:The Cancer Genome Atlas (TCGA) database indicated that a high level of HOXB4 in OV was correlated with poor prognosis. The biological functions ...

journal_title：BMC cancer

authors： Li N,Gou JH,Xiong J,You JJ,Li ZY

更新日期：2020-03-16 00:00:00

abstract：BACKGROUND:The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are associated with poorer survival in patients with gastric cancer. However, the effect of the white blood...

journal_title：BMC cancer

authors： Zheng HL,Lu J,Xie JW,Wang JB,Lin JX,Chen QY,Cao LL,Lin M,Tu RH,Huang ZN,Lin JL,Li P,Zheng CH,Huang CM

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attractive drug candidates for the targeted therapy of this malignancy. However, the ...

journal_title：BMC cancer

authors： Voisin L,Julien C,Duhamel S,Gopalbhai K,Claveau I,Saba-El-Leil MK,Rodrigue-Gervais IG,Gaboury L,Lamarre D,Basik M,Meloche S

更新日期：2008-11-17 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this disease. However, the mechanism of miRNA-induced mRNA cleavage remains to be investigated. METHOD:In...

journal_title：BMC cancer

authors： Zhou F,Tang D,Xu Y,He H,Wu Y,Lin L,Dong J,Tan W,Dai Y

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic approaches is imperatively needed for this disease. We have recently shown that activation of AMP-acti...

journal_title：BMC cancer

authors： Yung MM,Chan DW,Liu VW,Yao KM,Ngan HY

更新日期：2013-07-03 00:00:00

abstract：BACKGROUND:Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a subset of breast cancer with different biologic behaviour. We investigated the clinicopathologic charac...

journal_title：BMC cancer

authors： Rhee J,Han SW,Oh DY,Kim JH,Im SA,Han W,Park IA,Noh DY,Bang YJ,Kim TY

更新日期：2008-10-23 00:00:00

abstract：BACKGROUND:Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritoneum, lungs), or both. Observational and autopsy series report local recurrence rates of up to 87% eve...

journal_title：BMC cancer

authors： Tachezy M,Gebauer F,Petersen C,Arnold D,Trepel M,Wegscheider K,Schafhausen P,Bockhorn M,Izbicki JR,Yekebas E

更新日期：2014-06-07 00:00:00

abstract：BACKGROUND:The facts that LPA is present at high concentration in ovarian cancer patients' ascites and it may serve as a stimulator to cell migration, implicate the role of LPA in the ovarian cancer metastasis. Since LPA mediates various biological functions through its interaction with LPA receptors, we aim to investi...

journal_title：BMC cancer

authors： Yu X,Zhang Y,Chen H

更新日期：2016-11-04 00:00:00