Abstract:
BACKGROUND:MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the potential prognostic value of miR-21 in various types of human malignancy remains controversial. The present meta-analysis summarises and analyses the associations between miR-21 status and overall survival (OS) in a variety of tumours. METHODS:Eligible published studies were identified by searching the PubMed and Chinese Biomedicine databases. The patients' clinical characteristics and survival results were pooled, and a pooled hazard ratio (HR) with 95% confidence intervals (95% CI) was used to calculate the strength of this association. A random-effects model was adopted, and then, meta-regression and subgroup analyses were performed. In addition, an analysis of publication bias was also conducted. RESULTS:Twenty-seven eligible articles (including 31 studies) were identified that included survival data for 3273 patients. The pooled HR suggested that high miR-21 was clearly related to worse overall survival (HR = 2.27, 95% CI: 1.81-2.86), with a heterogeneity measure index of I2 = 76.0%, p = 0.001, showing that miR-21 might be a considerable prognostic factor for poor survival in cancer patients. CONCLUSIONS:MiR-21 might be a potentially useful biomarker for predicting cancer prognosis in future clinical applications.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wang W,Li J,Zhu W,Gao C,Jiang R,Li W,Hu Q,Zhang Bdoi
10.1186/1471-2407-14-819subject
Has Abstractpub_date
2014-11-07 00:00:00pages
819issn
1471-2407pii
1471-2407-14-819journal_volume
14pub_type
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