Abstract:
BACKGROUND:The purpose of the present study was to obtain information on the use of PD-1/PD-L1 inhibitors by oncologists in China through a national questionnaire survey. METHODS:Between the 7th and 25th of July in 2019, a questionnaire designed by the Chinese Society of Clinical Oncology Immuno-Oncology (CSCO IO) Committee on the current status of the use of PD-1/PD-L1 inhibitors was distributed online and offline to cancer-related medical departments in thirty different provinces and autonomous regions of China. The national questionnaire consisted of three sections as follows: general information, current status of the application of PD-1/PD-L1 inhibitors in the clinic, and oncologists' concerns regarding utilization. RESULTS:The valid response rate of the current status survey was 76.3%. The proportion of senior doctors (physician-in-charge or a more superior position for more than 3 years) among the respondents was relatively high (67.0% in 588). Of the respondents, 59.2% had prescribed PD-1/PD-L1 inhibitors during clinical treatment, and the most frequent reason for not prescribing these inhibitors was the choice "do not understand the mechanism and the efficacy of PD-1/PD-L1 inhibitors". In addition, 77.9% of the prescribers used the medications in an off-label situation, and the most important motivation for this use was the fact that "there were indications abroad but not domestically". In addition, 77.9% of the prescribers believed that "immunotherapy-related adverse effects could be controlled or intervened through follow-up management". The prescribers were mostly concerned about "how to identify pseudoprogression and hyperprogression" and "immunity-related adverse effects management". CONCLUSION:The present study highlights the current status of PD-1/PD-L1 inhibitors in China. Increasing numbers of medical oncologists are interested in PD-1/PD-L1 inhibitors, and they are in need of immunotherapy education.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Zhang B,Song Y,Fu Y,Zhu B,Wang B,Wang Jdoi
10.1186/s12885-020-6583-3subject
Has Abstractpub_date
2020-01-31 00:00:00pages
86issue
1issn
1471-2407pii
10.1186/s12885-020-6583-3journal_volume
20pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Increased level of serum S100B can serve as a marker of metastatic spread in patients with cutaneous melanoma (CM). In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and planning treatment.The aims of this study were to det...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-328
更新日期:2011-08-02 00:00:00
abstract:BACKGROUND:The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients receiving palliative care. METHODS:A retrospective review of clinicopathological data from 378 cons...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3498-8
更新日期:2017-08-02 00:00:00
abstract:BACKGROUND:Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. METHODS:This study included ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4305-x
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4221-0
更新日期:2018-03-22 00:00:00
abstract:BACKGROUND:To date, no single colorectal cancer (CRC) screening strategy has been determined to be applicable worldwide. In China, a CRC screening protocol that combines double fecal immunochemical tests (FITs) and a high-risk factor questionnaire (HRFQ) as the first stage of screening and colonoscopy as the second sta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5191-y
更新日期:2019-01-10 00:00:00
abstract:BACKGROUND:Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes. This stud...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06865-7
更新日期:2020-04-21 00:00:00
abstract:BACKGROUND:Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor microenvironment. Such models are urgently needed. Mutations of the tumor p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07212-6
更新日期:2020-08-08 00:00:00
abstract:BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2134-3
更新日期:2016-02-16 00:00:00
abstract:BACKGROUND:Given their frequency of occurrence in the United States, cancer and heart disease often coexist. For patients requiring open-heart surgery, this raises concern that the use of cardiopulmonary bypass (CPB) may cause a transient immunosuppression with the potential to promote the spread and growth of coexisti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-519
更新日期:2013-11-03 00:00:00
abstract:BACKGROUND:RNA from exosomes and other microvesicles contain transcripts of tumour origin. In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients. METHODS:Microvesicle RNA from serum from patients with de-novo primary glioblastoma multiforme (N = 9...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-22
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. However, inherent heterogeneity and treatment-induced adaptation to drugs c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6479-2
更新日期:2020-01-02 00:00:00
abstract:BACKGROUND:Colon cancer patients with the same stage show diverse clinical behavior due to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray expression patterns, to analyze whether the molecular classification correlated with the histopathological stages or other clinical paramete...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-260
更新日期:2012-06-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-020-07245-x
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The scientific and public debate concerning organized mammography screening is unprecedentedly strong. With research evidence concerning its efficacy being ambiguous, the recommendations pertaining to the age-thresholds for program inclusion vary between - and even within - countries. Data shows that young w...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3180-1
更新日期:2017-03-21 00:00:00
abstract:BACKGROUND:E2F1 transcription factor plays a vital role in the regulation of diverse cellular processes including cell proliferation, apoptosis, invasion and metastasis. E2F1 overexpression has been demonstrated in small cell lung cancer (SCLC), and extensive metastasis in early phase is the most important feature of S...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-276
更新日期:2014-04-22 00:00:00
abstract:BACKGROUND:The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy. METHODS:Medical notes of 174 NPC patients a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4348-z
更新日期:2018-05-18 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available treating options have prolonged patient's survival. However, BRAF-mutated CRC patients remain unres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6586-0
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-259
更新日期:2010-06-04 00:00:00
abstract:BACKGROUND:Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07733-0
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:Breast cancer is the most common malignancy in women world-wide. Triple negative breast cancer (TNBC) is a highly aggressive subtype that lacks expression of hormone receptors for estrogen, progesterone and human epidermal growth factor 2; and is associated with a high propensity for metastatic spread. Sever...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-253
更新日期:2014-04-11 00:00:00
abstract:BACKGROUND:No scientific consensus has been reached on whether active tobacco smoking causes breast cancer. We examine the association between active smoking and breast cancer risk in Denmark, which has some of the highest smoking and breast cancer rates in women worldwide. METHODS:We used the data from a nationwide D...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3546-4
更新日期:2017-08-22 00:00:00
abstract:BACKGROUND:Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity and resistance. In dividing cells, traditional metrics derived from dose-response curves such as IC...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3689-3
更新日期:2017-10-24 00:00:00
abstract:BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-71
更新日期:2008-03-10 00:00:00
abstract:BACKGROUND:Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. METHODS:We reviewed our database of ER-positiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2423-x
更新日期:2016-07-07 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). The cardiotoxic effects of sorafenib and sunitinib may cause hypertension, left ventricular ejection fraction (LVEF) dysfunction and/or congestive heart failure (CHF), and arterial thrombo-em...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-231
更新日期:2012-06-11 00:00:00
abstract:BACKGROUND:KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src. However, the underl...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-81
更新日期:2012-03-06 00:00:00
abstract:BACKGROUND:Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer. METHODS:A total of 301 consecutive patients (mean age, 49.8 ± 11.0 years; range, 29-86 years) with breast cancer confirmed by patho...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6578-0
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the severity of pain and its impact on the quality of life (QoL) in untreated patients with head and neck squamous cell carcinoma (HNSCC). METHODS:A study group of 127 patients with HNSCC were interviewed before antineoplastic treatment. The severity of pain was measured ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-39
更新日期:2014-01-24 00:00:00
abstract:BACKGROUND:First-line treatment with FOLFOXIRI plus bevacizumab (BEV) is highly effective and regarded as one of the standards-of-care for patients with metastatic colorectal cancer (mCRC), despite the high incidence of neutropenia and diarrhea as side effects. AXEPT, an Asian phase III study, showed that modified CAPI...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07186-5
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment. METHODS:We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2504-x
更新日期:2016-07-20 00:00:00