Abstract:
BACKGROUND:Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes. This study evaluated the efficacy and safety of salvage-line ramucirumab monotherapy for treating AGC. METHODS:The subjects of this retrospective study were advanced gastric or gastro-esophageal junction adenocarcinoma patients who received ramucirumab monotherapy after failure of 2 or more prior regimens containing fluoropyrimidine and taxanes but not ramucirumab. RESULTS:From June 2015 to April 2017, 51 patients were enrolled. The median progression-free survival (PFS) and overall survival (OS) were 1.8 (95% confidence interval [CI] = 1.6-2.2) and 5.1 (95% CI = 4.0-6.8) months, respectively. The objective response and disease control rates were 2 and 17%, respectively. Grade 3 adverse events (AEs; e.g., anemia, fatigue, hypertension, proteinuria, intestinal bleeding) occurred in seven (13%) patients, but no grade 4 AEs and treatment-related deaths were observed. A neutrophil-lymphocyte ratio (NLR) of < 2.5 and previous gastrectomy were associated with better PFS. CONCLUSIONS:Salvage-line ramucirumab monotherapy has acceptable toxicity and comparable efficacy to second-line treatment; therefore, we consider physicians might choose this therapy as a salvage-line treatment option for AGC refractory to the standard therapies.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Kawai S,Fukuda N,Yamamoto S,Mitani S,Omae K,Wakatsuki T,Kato K,Kadowaki S,Takahari D,Boku N,Muro K,Machida Ndoi
10.1186/s12885-020-06865-7subject
Has Abstractpub_date
2020-04-21 00:00:00pages
338issue
1issn
1471-2407pii
10.1186/s12885-020-06865-7journal_volume
20pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Increased level of serum S100B can serve as a marker of metastatic spread in patients with cutaneous melanoma (CM). In patients with elevated S100 B and/or clinical signs of disease progression PET-CT scan is a valuable tool for discovering metastases and planning treatment.The aims of this study were to det...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-328
更新日期:2011-08-02 00:00:00
abstract:BACKGROUND:It is well known that osteopontin (OPN) plays an important role in tumor progression and that a high OPN expression level in several tumor entities correlates with poor prognosis in cancer patients. However, little is known about the prognostic relevance of the OPN mRNA splice variants. METHODS:We analyzed ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-131
更新日期:2012-04-02 00:00:00
abstract:BACKGROUND:Breast cancer can impact survivors in many aspects of their life. Scarce information is currently available on the quality of life of cancer survivors in Bahrain. The objective of this study is to describe the quality of life of Bahraini women with breast cancer and its association with their sociodemographi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-212
更新日期:2013-04-28 00:00:00
abstract:BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1784-x
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans. METHODS:Medical records of African Americans,...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-296
更新日期:2014-04-28 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the short- and long-term outcomes after laparoscopic resection for low rectal cancer (LRC) compared with mid/high rectal cancer (M/HRC). METHODS:Patients with rectal cancer undergoing laparoscopic resection with curative intent were retrospectively reviewed between 2009 and 2015...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07255-9
更新日期:2020-08-14 00:00:00
abstract:BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1317-7
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. Variant that arises in the pouch o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-171
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone metastasis was investigated in a cohort of patients. We have tried to draw the criteria to use adjuvant bisphosphonate. METHODS:Consecutive breast cancer patients undergoing surgery between 19...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-10-381
更新日期:2010-07-21 00:00:00
abstract:BACKGROUND:To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC). METHODS:The specimens of NSCLC from 305 Chinese patients with follow-up were analyzed for CD133 protein expression and VM by immunohistochemical and histoche...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-535
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear. METHODS:The Cancer Genome Atlas (TCGA) database indicated that a high level of HOXB4 in OV was correlated with poor prognosis. The biological functions ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06725-4
更新日期:2020-03-16 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07766-5
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia prom...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-108
更新日期:2013-03-09 00:00:00
abstract:BACKGROUND:Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-343
更新日期:2009-09-25 00:00:00
abstract:BACKGROUND:Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic vir...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-366
更新日期:2012-08-23 00:00:00
abstract:BACKGROUND:Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney cancer is rising across the sexes in some of these countries, a trend which may possibly reflect the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-293
更新日期:2008-10-09 00:00:00
abstract:BACKGROUND:Overweight and weight gain throughout adult life have been associated with increased risk of breast cancer after the menopause. However the role of body weight at a young age and of the timing of weight gain over the lifetime in postmenopausal breast cancer is not well documented. METHODS:We conducted a pop...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2793-0
更新日期:2016-09-29 00:00:00
abstract:BACKGROUND:A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4438-y
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-390
更新日期:2008-12-25 00:00:00
abstract:BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-228
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:Breast cancer is the most common cancer in women worldwide, with a great diversity in outcomes among individual patients. The ability to accurately predict a breast cancer outcome is important to patients, physicians, researchers, and policy makers. Many models have been developed and tested in different set...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5442-6
更新日期:2019-03-14 00:00:00
abstract:BACKGROUND:Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor signaling cascades are kn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1363-1
更新日期:2015-05-08 00:00:00
abstract:BACKGROUND:Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and a good prognostic indicator for lung adenocarcinoma. However, its good prognostic ability might be due to epidermal growth factor receptor (EGFR)-sensitizing mutations as shown by the positive correlation between TTF-1 expression and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5792-0
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition. METHODS:GSCs from human U87 and rat C6 glioblastoma cell lines were isolated via magnetic cell sorting using CD133 as a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3924-y
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-85
更新日期:2009-03-17 00:00:00
abstract:BACKGROUND:Radium-223 has been shown to improve overall survival in men with metastatic castration-resistant prostate cancer with symptomatic bone metastases. The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1390-y
更新日期:2015-05-07 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-92
更新日期:2009-03-25 00:00:00
abstract:BACKGROUND:Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study was to establish whether platinum-based combination chemotherapy may by beneficial in this patient ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-140
更新日期:2014-02-27 00:00:00
abstract:BACKGROUND:To investigate the association between physical activity (PA) and quality of life (QoL) among breast and colorectal cancer survivors in Korea. METHODS:A total of 224 cancer survivors (151 breast and 73 colorectal cancers) who completed treatments were recruited. We measured PA level with Godin Leisure-Time ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06819-z
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were de...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-566
更新日期:2012-12-02 00:00:00