Influence of tumor location on short- and long-term outcomes after laparoscopic surgery for rectal cancer: a propensity score matched cohort study.

abstract：BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...

journal_title：BMC cancer

authors： Ejegod DM,Rebolj M,Bonde J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Brain metastases (BM) represent one of the most frequent complications related to cancer, and their treatment continues to evolve. We have evaluated the activity, toxicity and the impact on Quality of Life (QoL) of a concomitant treatment with whole brain radiotherapy (WBRT) and Temozolomide (TMZ) in patient...

journal_title：BMC cancer

authors： Addeo R,Caraglia M,Faiola V,Capasso E,Vincenzi B,Montella L,Guarrasi R,Caserta L,Del Prete S

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:MicroRNAs (miRs) represent a distinct class of posttranscriptional modulators of gene expression with remarkable stability in sera. Several miRs are oncogenic (oncomiRs) and are deregulated in the pathogenesis of breast cancer and function to inhibit tumor suppressors. Routine blood monitoring of these circu...

journal_title：BMC cancer

authors： Sochor M,Basova P,Pesta M,Dusilkova N,Bartos J,Burda P,Pospisil V,Stopka T

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The development of artificial intelligence (AI) provides a new method for BI-RADS categorisation. We analysed the...

journal_title：BMC cancer

authors： Niu S,Huang J,Li J,Liu X,Wang D,Zhang R,Wang Y,Shen H,Qi M,Xiao Y,Guan M,Liu H,Li D,Liu F,Wang X,Xiong Y,Gao S,Wang X,Zhu J

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:The incidence of Cholangiocellular Carcinoma (CCA) is increasing in the western world. The tumour has a high proportion of desmoplastic stroma and is correlated with a worse prognosis when cancer associated myofibroblasts (CAFs) are present. Recent studies showed promising results after liver transplantation...

journal_title：BMC cancer

authors： Heits N,Heinze T,Bernsmeier A,Kerber J,Hauser C,Becker T,Kalthoff H,Egberts JH,Braun F

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...

journal_title：BMC cancer

authors： Xu H,Xu Y,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with renal cell carcinoma (RCC). METHODS:EZH2 protein expression in RC...

journal_title：BMC cancer

authors： Wagener N,Macher-Goeppinger S,Pritsch M,Hüsing J,Hoppe-Seyler K,Schirmacher P,Pfitzenmaier J,Haferkamp A,Hoppe-Seyler F,Hohenfellner M

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...

journal_title：BMC cancer

authors： Matsushita J,Okamura K,Nakabayashi K,Suzuki T,Horibe Y,Kawai T,Sakurai T,Yamashita S,Higami Y,Ichihara G,Hata K,Nohara K

更新日期：2018-03-22 00:00:00

abstract：BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...

journal_title：BMC cancer

authors： Kim J,Roh M,Abdulkadir SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:RhoC is a small G protein/GTPase and involved in tumor mobility, invasion and metastasis. Previously, up-regulated RhoC expression is found to play an important role in ovarian carcinogenesis and subsequent progression by modulating proliferation, apoptosis, migration and invasion. METHODS:We transfected Rh...

journal_title：BMC cancer

authors： Gou WF,Zhao Y,Lu H,Yang XF,Xiu YL,Zhao S,Liu JM,Zhu ZT,Sun HZ,Liu YP,Xu F,Takano Y,Zheng HC

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION:We report the case of a 51 year old ma...

journal_title：BMC cancer

authors： Rochigneux P,Thomassin-Piana J,Laibe S,Brunelle S,Salem N,Escudier B,Vassal G,Gravis G

更新日期：2018-11-22 00:00:00

abstract：BACKGROUND:Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are use...

journal_title：BMC cancer

authors： Varona A,Blanco L,Perez I,Gil J,Irazusta J,López JI,Candenas ML,Pinto FM,Larrinaga G

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons. Using this treatment regimen, overall survival could be extended significantly however, median overall survival is still onl...

journal_title：BMC cancer

authors： Combs SE,Kieser M,Rieken S,Habermehl D,Jäkel O,Haberer T,Nikoghosyan A,Haselmann R,Unterberg A,Wick W,Debus J

更新日期：2010-09-06 00:00:00

abstract：BACKGROUND:Liver resection had been regarded as a standard treatment for primary hepatocellular carcinoma (HCC). However, early mortality and recurrence after surgery were still of major concern. RAM (Risk Assessment for early Mortality) scoring system is a newly developed tool for assessing early mortality after hepat...

journal_title：BMC cancer

authors： Hsu HY,Yu MC,Lee CW,Tsai HI,Sung CM,Chen CW,Huang SW,Lin CY,Jeng WJ,Lee WC,Chen MF

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:XELOX (capecitabine + oxaliplatin) and FOLFOX 4 (5-FU + folinic acid + oxaliplatin) have shown similar improvements in survival in patients with metastatic colorectal cancer (MCRC). A US cost-minimization study found that the two regimens had similar costs from a healthcare provider perspective but XELOX had...

journal_title：BMC cancer

authors： Tse VC,Ng WT,Lee V,Lee AW,Chua DT,Chau J,McGhee SM

更新日期：2011-07-09 00:00:00

abstract：BACKGROUND:Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms f...

journal_title：BMC cancer

authors： Blank S,Rachakonda S,Keller G,Weichert W,Lordick F,Langer R,Springfeld C,Bruckner T,Becker K,Kumar R,Ott K

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and m...

journal_title：BMC cancer

authors： Schaefer IM,Günnel H,Schweyer S,Korenkov M

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs of the two drugs among patients with mRCC/advanced RCC (aRCC). MATERIALS AND METHODS:PubMed, Scien...

journal_title：BMC cancer

authors： Deng H,Huang Y,Hong Z,Yuan X,Cao Z,Wei Y,Zhang W

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the incidence and prognostic value of disseminated tumor cells in bone marrow of breast carcinoma patients with early disease, and to analyze this finding in relation to lymph node involvement, determined by sentinel lymph node (SLN) biopsy analysis, and to prognostic...

journal_title：BMC cancer

authors： Solá M,Margelí M,Castellá E,Julian JF,Rull M,Gubern JM,Mariscal A,Barnadas A,Fraile M

更新日期：2011-06-16 00:00:00

abstract：BACKGROUND:We examined 15 years of key performance indicators (KPIs) of the population-based mammography screening programme (PMSP) in Flanders, Belgium. METHODS:Individual screening data were linked to the national cancer registry to obtain oncological follow-up. We benchmarked crude KPI results against KPI-targets s...

journal_title：BMC cancer

authors： Goossens M,De Brabander I,De Grève J,Van Ongeval C,Martens P,Van Limbergen E,Kellen E

更新日期：2019-10-28 00:00:00

abstract：PURPOSE:Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practitioners is not well known. METHODS:Two nationwide observational telephone surveys were conducted in early ...

journal_title：BMC cancer

authors： Eisinger F,Cals L,Calazel-Benque A,Blay JY,Coscas Y,Dolbeault S,Namer M,Pivot X,Rixe O,Serin D,Roussel C,Morère JF,EDIFICE committee.

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:The aim of this study was to compare surgical treatment received by Aboriginal and non-Aboriginal people with non-small cell lung cancer (NSCLC) in New South Wales (NSW), Australia and to examine whether patient and disease characteristics are associated with any disparities found. An additional objective wa...

journal_title：BMC cancer

authors： Gibberd A,Supramaniam R,Dillon A,Armstrong BK,O'Connell DL

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associated with the real-world mortality risk. METHODS:This was a retrospective German claims data analys...

journal_title：BMC cancer

authors： Hardtstock F,Myers D,Li T,Cizova D,Maywald U,Wilke T,Griesinger F

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...

journal_title：BMC cancer

authors： Letessier A,Sircoulomb F,Ginestier C,Cervera N,Monville F,Gelsi-Boyer V,Esterni B,Geneix J,Finetti P,Zemmour C,Viens P,Charafe-Jauffret E,Jacquemier J,Birnbaum D,Chaffanet M

更新日期：2006-10-13 00:00:00

abstract：BACKGROUND:The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts surviva...

journal_title：BMC cancer

authors： Westgaard A,Tafjord S,Farstad IN,Cvancarova M,Eide TJ,Mathisen O,Clausen OP,Gladhaug IP

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...

journal_title：BMC cancer

authors： Itoh A,Sadamori H,Yabushita K,Monden K,Tatsukawa M,Hioki M,Hyodo T,Omonishi K,Ueki T,Ohno S,Sakaguchi K,Takakura N

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dialysis. The objective of the FASTRACK II clinical trial is to investigate the efficacy of SABR for pr...

journal_title：BMC cancer

authors： Siva S,Chesson B,Bressel M,Pryor D,Higgs B,Reynolds HM,Hardcastle N,Montgomery R,Vanneste B,Khoo V,Ruben J,Lau E,Hofman MS,De Abreu Lourenco R,Sridharan S,Brook NR,Martin J,Lawrentschuk N,Kron T,Foroudi F

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. METHODS:A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall surviv...

journal_title：BMC cancer

authors： Choi JH,Choi YW,Kang SY,Jeong GS,Lee HW,Jeong SH,Park JS,Ahn MS,Sheen SS

更新日期：2020-03-02 00:00:00

abstract：BACKGROUND:Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lentivirus-mediated cytosine deaminase-thymidine kinase (CDglyTK) gene in transplanted breast cancer deli...

journal_title：BMC cancer

authors： Zhang J,Liu Y,Zang M,Zhu S,Chen B,Li S,Xue B,Yan L

更新日期：2019-09-14 00:00:00

abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...

journal_title：BMC cancer

authors： Wang L,Wang R,Pan Y,Sun Y,Zhang J,Chen H

更新日期：2014-03-19 00:00:00