Lentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer.

abstract：BACKGROUND:Regulatory T cells (Tregs), particularly the CD4(+)CD25(+)Foxp3(+) Tregs, down regulate immunity and promote tumor cell growth by directly suppressing CD8(+) and CD4(+) T cells. Alternatively they can promote tumor growth by generating interleukin-10 (IL-10) and transforming growth factor β (TGFβ) in situ, w...

journal_title：BMC cancer

authors： Yu Y,Huang R,Zong X,He X,Mo W

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve t...

journal_title：BMC cancer

authors： Caponigro F,Di Gennaro E,Ionna F,Longo F,Aversa C,Pavone E,Maglione MG,Di Marzo M,Muto P,Cavalcanti E,Petrillo A,Sandomenico F,Maiolino P,D'Aniello R,Botti G,De Cecio R,Losito NS,Scala S,Trotta A,Zotti AI,Bruzzese

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. However, the majority of hu...

journal_title：BMC cancer

authors： Ohnstad HO,Paulsen EB,Noordhuis P,Berg M,Lothe RA,Vassilev LT,Myklebost O

更新日期：2011-05-30 00:00:00

abstract：BACKGROUND:Locally advanced or metastatic adenocarcinoma of the pancreas remains - despite the implementation of new chemotherapy protocols - a disease with short overall survival (OS). METHODS:Eighty-three patients were treated with locally advanced or metastatic adenocarcinoma of the pancreas with either FOLFIRINOX ...

journal_title：BMC cancer

authors： Vogl UM,Andalibi H,Klaus A,Vormittag L,Schima W,Heinrich B,Kafka A,Winkler T,Öhler L

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Angiogenesis is a proliferative process resulting in the development of new blood vessels from existing endothelial cells and is considered crucial for tumor growth and metastasis. Tumor angiogenesis can be quantified by microvascular density (MVD), which is evaluated in highly vascularized tumor areas (hot ...

journal_title：BMC cancer

authors： Paschoal JP,Bernardo V,Canedo NH,Ribeiro OD,Caroli-Bottino A,Pannain VL

更新日期：2014-02-07 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating disease. The aim of this study was to evaluate hyperprogression in patients with malignant tumors of d...

journal_title：BMC cancer

authors： Ji Z,Peng Z,Gong J,Zhang X,Li J,Lu M,Lu Z,Shen L

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50-60 Gy irradiation in breast cancer. However, these agents are also often used clinically for the control of radiation dermatitis induced by high-dose (>60Gy) irradiation with chemotherapy in...

journal_title：BMC cancer

authors： Zenda S,Yamaguchi T,Yokota T,Miyaji T,Mashiko T,Tanaka M,Yonemura M,Takeno M,Okano T,Kawasaki T,Nakamori Y,Ishii S,Shimada S,Kanamaru M,Uchitomi Y

更新日期：2018-09-06 00:00:00

abstract：BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...

journal_title：BMC cancer

authors： Kim MJ,Ki MS,Kim K,Shim HJ,Hwang JE,Bae WK,Chung IJ,Lee DH,Lee JK,Yoon TM,Lim SC,Chung WK,Jeong JU,Lim HS,Choi YD,Cho SH

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:Fos-related antigen 1 (FRA-1) is an immediate early gene encoding a member of AP-1 family of transcription factors involved in cell proliferation, differentiation, apoptosis, and other biological processes. fra-1 gene overexpression has an important role in the process of cellular transformation, and our pre...

journal_title：BMC cancer

authors： Chiappetta G,Ferraro A,Botti G,Monaco M,Pasquinelli R,Vuttariello E,Arnaldi L,Di Bonito M,D'Aiuto G,Pierantoni GM,Fusco A

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...

journal_title：BMC cancer

authors： Cleary CM,White KM,Young RM,Hawkes AL,Leske S,Starfelt LC,Wihardjo K

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This study investigated the role of hyaluronan (HA) and a potential link between the HA-CD44 pathway and...

journal_title：BMC cancer

authors： Ricciardelli C,Ween MP,Lokman NA,Tan IA,Pyragius CE,Oehler MK

更新日期：2013-10-14 00:00:00

abstract：BACKGROUND:The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attractive drug candidates for the targeted therapy of this malignancy. However, the ...

journal_title：BMC cancer

authors： Voisin L,Julien C,Duhamel S,Gopalbhai K,Claveau I,Saba-El-Leil MK,Rodrigue-Gervais IG,Gaboury L,Lamarre D,Basik M,Meloche S

更新日期：2008-11-17 00:00:00

abstract：BACKGROUND:Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenv...

journal_title：BMC cancer

authors： Schlüter A,Weller P,Kanaan O,Nel I,Heusgen L,Höing B,Haßkamp P,Zander S,Mandapathil M,Dominas N,Arnolds J,Stuck BA,Lang S,Bankfalvi A,Brandau S

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim of the present work was to study the growth inhibition of tumor cells by butanol extract of Bifidobac...

journal_title：BMC cancer

authors： Lee DK,Jang S,Kim MJ,Kim JH,Chung MJ,Kim KJ,Ha NJ

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:Over-expression of HER2 in a subset of breast cancers (HER2+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of HER2+ patients to both adjuvant cytotoxic chemotherapy and targeted therapy (e.g. trastuzumab) suggests t...

journal_title：BMC cancer

authors： Hicks DG,Janarthanan BR,Vardarajan R,Kulkarni SA,Khoury T,Dim D,Budd GT,Yoder BJ,Tubbs R,Schreeder MT,Estopinal NC,Beck RA,Wang Y,Ring BZ,Seitz RS,Ross DT

更新日期：2010-03-22 00:00:00

abstract：BACKGROUND:Presently available flow cytometric methods of bromodeoxyuridine (BrdUrd) labelling do not provide information on the cell cycle time (TC) and the growth fraction (GF). In this paper, we describe a novel and simple method to estimate TC and GF from flow cytometric analysis of a single tumour sample after Brd...

journal_title：BMC cancer

authors： Eidukevicius R,Characiejus D,Janavicius R,Kazlauskaite N,Pasukoniene V,Mauricas M,Den Otter W

更新日期：2005-09-22 00:00:00

abstract：BACKGROUND:Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. Due to the high frequency of breast cancer in LFS/LFL families, these...

journal_title：BMC cancer

authors： Silva AG,Ewald IP,Sapienza M,Pinheiro M,Peixoto A,de Nóbrega AF,Carraro DM,Teixeira MR,Ashton-Prolla P,Achatz MI,Rosenberg C,Krepischi AC

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been reported to promote tumorigenesis and progression in several human malignancies. The purpose of this study was to explore the function of BDNF in lung squamous cell carcinoma (SCC) and adenocarcinoma (ADC). METHODS:The expression of BDNF was examined in 110 ...

journal_title：BMC cancer

authors： Zhang SY,Hui LP,Li CY,Gao J,Cui ZS,Qiu XS

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Rhabdoid tumors are rare cancers of early childhood arising in the kidney, central nervous system and other organs. The majority are caused by somatic inactivating mutations or deletions affecting the tumor suppressor locus SMARCB1 [OMIM 601607]. Germ-line SMARCB1 inactivation has been reported in associatio...

journal_title：BMC cancer

authors： Dagar V,Chow CW,Ashley DM,Algar EM

更新日期：2009-12-13 00:00:00

abstract：BACKGROUND:Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for therapy due to its high activation in GBMs as well as other cancers. The dual pan-PI3K/mTOR kinase...

journal_title：BMC cancer

authors： Netland IA,Førde HE,Sleire L,Leiss L,Rahman MA,Skeie BS,Gjerde CH,Enger PØ,Goplen D

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear. METHODS:The Cancer Genome Atlas (TCGA) database indicated that a high level of HOXB4 in OV was correlated with poor prognosis. The biological functions ...

journal_title：BMC cancer

authors： Li N,Gou JH,Xiong J,You JJ,Li ZY

更新日期：2020-03-16 00:00:00

abstract：BACKGROUND:Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the degradation of ECM macromolecules. The MMPs and their nat...

journal_title：BMC cancer

authors： Balducci C,Lilli C,Stabellini G,Marinucci L,Giustozzi G,Becchetti A,Cagini L,Locci P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23-31 months. There are several treatment options including chemotherapy and sometimes endocrine therapy. Currently, there is no standard treatment for patients with MBC who have already be...

journal_title：BMC cancer

authors： Fumet JD,Wickre M,Jacquot JP,Bizollon MH,Melis A,Vanoli A,Viel E

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. These findings suggest that E6 performs critical functions in normal adult cervix and skin, highli...

journal_title：BMC cancer

authors： Mendoza-Villanueva D,Diaz-Chavez J,Uribe-Figueroa L,Rangel-Escareão C,Hidalgo-Miranda A,March-Mifsut S,Jimenez-Sanchez G,Lambert P,Gariglio P

更新日期：2008-11-26 00:00:00

abstract：BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...

journal_title：BMC cancer

authors： Martarelli D,Catalano A,Procopio A,Orecchia S,Libener R,Santoni G

更新日期：2006-05-17 00:00:00

abstract：BACKGROUND:Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsi...

journal_title：BMC cancer

authors： Yu Y,Wang Q,Sun J,Zhao J,Chen S,Li Y

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast cancer. The current study evaluated the prognostic impact of TOP2A protein on luminal breast cancer....

journal_title：BMC cancer

authors： An X,Xu F,Luo R,Zheng Q,Lu J,Yang Y,Qin T,Yuan Z,Shi Y,Jiang W,Wang S

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic ant...

journal_title：BMC cancer

authors： Eilard MS,Andersson M,Naredi P,Geronymakis C,Lindnér P,Cahlin C,Bennet W,Rizell M

更新日期：2019-06-11 00:00:00

abstract：BACKGROUND:Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The purpose of this study was to investigate the prognostic factors for disease-specific survival at the in...

journal_title：BMC cancer

authors： Shinoda Y,Kobayashi E,Kobayashi H,Mori T,Asano N,Nakayama R,Morioka H,Iwata S,Yonemoto T,Ishii T,Hiruma T,Kawai A,Kawano H

更新日期：2020-09-14 00:00:00