Different protein expression associated with chemotherapy response in oropharyngeal cancer according to HPV status.

abstract：BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...

journal_title：BMC cancer

authors： Chatterjee A,Mambo E,Zhang Y,Deweese T,Sidransky D

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathway in chondrosarcoma to determine if it can be a target for therapy, which was therefore explored in ...

journal_title：BMC cancer

authors： Peterse EF,Cleven AH,De Jong Y,Briaire-de Bruijn I,Fletcher JA,Danen EH,Cleton-Jansen AM,Bovée JV

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia prom...

journal_title：BMC cancer

authors： Zhang L,Huang G,Li X,Zhang Y,Jiang Y,Shen J,Liu J,Wang Q,Zhu J,Feng X,Dong J,Qian C

更新日期：2013-03-09 00:00:00

abstract：BACKGROUND:In Europe, gastric cancer remains diagnosed at advanced stage (serosal and/or lymph node involvement). Despite curative management combining perioperative systemic chemotherapy and gastrectomy with D1-D2 lymph node dissection, 5-year survival rates of T3 and/or N + patients remain under 30%. More than 50% of...

journal_title：BMC cancer

authors： Glehen O,Passot G,Villeneuve L,Vaudoyer D,Bin-Dorel S,Boschetti G,Piaton E,Garofalo A

更新日期：2014-03-14 00:00:00

abstract：BACKGROUND:Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study its expression at protein level in HCC and its biological function for HCC cell growth. METHOD:Weste...

journal_title：BMC cancer

authors： Guo M,Li J,Wan D,Gu J

更新日期：2006-04-29 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need for repeat surgery. This individual patient data (IPD) meta-analysis examines MRI's agreement with pa...

journal_title：BMC cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,Mamounas E,von Minckwitz G,Guarneri V,Partridge SC,Wright FC,Choi JH,Bhattacharyya M,Martincich L,Yeh E,Londero V,Houssami N

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the popu...

journal_title：BMC cancer

authors： Yoshimura A,Yamada T,Okura N,Takeda T,Furutani W,Kubota Y,Shiotsu S,Hiranuma O,Nishioka N,Chihara Y,Tamiya N,Kaneko Y,Uchino J,Takayama K

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...

journal_title：BMC cancer

authors： Ordás J,Millán Y,Dios R,Reymundo C,de Las Mulas JM

更新日期：2007-09-20 00:00:00

abstract：BACKGROUND:A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. METHODS:In order to evaluate the NuMa gene for breast cancer sus...

journal_title：BMC cancer

authors： Kilpivaara O,Rantanen M,Tamminen A,Aittomäki K,Blomqvist C,Nevanlinna H

更新日期：2008-03-10 00:00:00

abstract：BACKGROUND:The influence of the tumor microenvironment and tumor-stromal interactions on the heterogeneity of response within breast cancer subtypes have just begun to be explored. This study focuses on patients with estrogen receptor-positive/human epidermal growth factor receptor 2-positive (ER+/HER2+) breast cancer ...

journal_title：BMC cancer

authors： Brodsky AS,Xiong J,Yang D,Schorl C,Fenton MA,Graves TA,Sikov WM,Resnick MB,Wang Y

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk. METHODS:Fifty-five thousand nine hundred thirty-seven cases (all prostate canc...

journal_title：BMC cancer

authors： Beckmann K,Russell B,Josephs D,Garmo H,Haggstrom C,Holmberg L,Stattin P,Van Hemelrijck M,Adolfsson J

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...

journal_title：BMC cancer

authors： Glockzin G,Gerken M,Lang SA,Klinkhammer-Schalke M,Piso P,Schlitt HJ

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...

journal_title：BMC cancer

authors： Xia B,Hou L,Kang H,Chang W,Liu Y,Zhang Y,Ding Y

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Neuroendocrine tumors (NETs) of the esophagus are extremely rare, and few cases have been reported worldwide. Thus, a comprehensive nationwide study is needed to understand the characteristics of and treatment strategy for esophageal NETs. METHODS:We collected data on esophageal NET patients from 25 hospita...

journal_title：BMC cancer

authors： Lee CG,Lim YJ,Park SJ,Jang BI,Choi SR,Kim JK,Kim YT,Cho JY,Yang CH,Chun HJ,Song SY,Neuroendocrine tumor study group.

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:The incidence of thyroid cancer and the number of patients who die from this disease are increasing globally. Differentiated thyroid cancer (DTC) is the histologic subtype present in most patients and is primarily responsible for the increased overall incidence of thyroid cancer. Sorafenib is a multikinase i...

journal_title：BMC cancer

authors： Brose MS,Nutting CM,Sherman SI,Shong YK,Smit JW,Reike G,Chung J,Kalmus J,Kappeler C,Schlumberger M

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (M...

journal_title：BMC cancer

authors： Zarzour AH,Selim M,Abd-Elsayed AA,Hameed DA,Abdelaziz MA

更新日期：2008-08-29 00:00:00

abstract：BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...

journal_title：BMC cancer

authors： Khaddour K,Singh V,Shayuk M

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities. Sigma-2 receptors, which are overexpressed in several tumors, represent promising targets for triggering selective pancreatic cancer cells death. METHODS:We selected five differe...

journal_title：BMC cancer

authors： Pati ML,Hornick JR,Niso M,Berardi F,Spitzer D,Abate C,Hawkins W

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Renal cell carcinoma (RCC) is a seventh ranked malignancy with poor prognosis. RCC is lethal at metastatic stage as it does not respond to conventional systemic treatments, and there is an urgent need to find out promising novel biomarkers for effective treatment. The goal of this study was to evaluate the b...

journal_title：BMC cancer

authors： Karim S,Al-Maghrabi JA,Farsi HM,Al-Sayyad AJ,Schulten HJ,Buhmeida A,Mirza Z,Al-Boogmi AA,Ashgan FT,Shabaad MM,NourEldin HF,Al-Ghamdi KB,Abuzenadah A,Chaudhary AG,Al-Qahtani MH

更新日期：2016-09-30 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutati...

journal_title：BMC cancer

authors： Kitkumthorn N,Yanatatsanajit P,Kiatpongsan S,Phokaew C,Triratanachat S,Trivijitsilp P,Termrungruanglert W,Tresukosol D,Niruthisard S,Mutirangura A

更新日期：2006-03-08 00:00:00

abstract：BACKGROUND:Standard radiotherapy is the treatment of first choice in patients with symptomatic spinal metastases, but is only moderately effective. Stereotactic body radiation therapy is increasingly used to treat spinal metastases, without randomized evidence of superiority over standard radiotherapy. The VERTICAL stu...

journal_title：BMC cancer

authors： van der Velden JM,Verkooijen HM,Seravalli E,Hes J,Gerlich AS,Kasperts N,Eppinga WS,Verlaan JJ,van Vulpen M

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and functional causality between CCR7 expression and lymph node metastasis in patients with esophageal squamous ...

journal_title：BMC cancer

authors： Irino T,Takeuchi H,Matsuda S,Saikawa Y,Kawakubo H,Wada N,Takahashi T,Nakamura R,Fukuda K,Omori T,Kitagawa Y

更新日期：2014-04-26 00:00:00

abstract：BACKGROUND:Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical instability and low cell penetrance. A new paradigm to improve Gemcitabine's therapeutic index is to a...

journal_title：BMC cancer

authors： Papa AL,Basu S,Sengupta P,Banerjee D,Sengupta S,Harfouche R

更新日期：2012-09-22 00:00:00

abstract：BACKGROUND:Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model's lack of cellular components of the tumor's microenvironment. In this study, we aim to determine if the intact lung micr...

journal_title：BMC cancer

authors： Mishra DK,Miller RA,Pence KA,Kim MP

更新日期：2018-04-18 00:00:00

abstract：BACKGROUND:Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-based regimens may be beneficial, particularly for patients with wild-type (WT) KRAS. CASE PRESENTAT...

journal_title：BMC cancer

authors： Ma J,Yang QL,Ling Y

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the androgen receptor (AR) and progesterone receptor (PgR) are expressed in MBC. AR activation in breas...

journal_title：BMC cancer

authors： Takuwa H,Tsuji W,Shintaku M,Yotsumoto F

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Febrile neutropenia (FN) occurs following myelosuppressive chemotherapy and is associated with morbidity, mortality, costs, and chemotherapy reductions and delays. Granulocyte colony-stimulating factors (G-CSFs) stimulate neutrophil production and may reduce FN incidence when given prophylactically following...

journal_title：BMC cancer

authors： Cooper KL,Madan J,Whyte S,Stevenson MD,Akehurst RL

更新日期：2011-09-23 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...

journal_title：BMC cancer

authors： Zoni E,Minoli M,Bovet C,Wehrhan A,Piscuoglio S,Ng CKY,Gray PC,Spahn M,Thalmann GN,Kruithof-de Julio M

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung cancer (NSCLC) specimens and cell lines. However, the underlying mechanisms of miR-148b in regulatin...

journal_title：BMC cancer

authors： Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

更新日期：2019-03-08 00:00:00