HOXB4 promotes the malignant progression of ovarian cancer via DHDDS.

abstract：BACKGROUND:Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 ...

journal_title：BMC cancer

authors： Jiang L,Campagne C,Sundström E,Sousa P,Imran S,Seltenhammer M,Pielberg G,Olsson MJ,Egidy G,Andersson L,Golovko A

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity an...

journal_title：BMC cancer

authors： Eskew JD,Sadikot T,Morales P,Duren A,Dunwiddie I,Swink M,Zhang X,Hembruff S,Donnelly A,Rajewski RA,Blagg BS,Manjarrez JR,Matts RL,Holzbeierlein JM,Vielhauer GA

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism. METHODS:The expre...

journal_title：BMC cancer

authors： Tu XP,Li H,Chen LS,Luo XN,Lu ZM,Zhang SY,Chen SH

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and postoperative chemotherapy. However, these reg...

journal_title：BMC cancer

authors： Slagter AE,Jansen EPM,van Laarhoven HWM,van Sandick JW,van Grieken NCT,Sikorska K,Cats A,Muller-Timmermans P,Hulshof MCCM,Boot H,Los M,Beerepoot LV,Peters FPJ,Hospers GAP,van Etten B,Hartgrink HH,van Berge Henegouwen MI,

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased express...

journal_title：BMC cancer

authors： Veltman JD,Lambers ME,van Nimwegen M,Hendriks RW,Hoogsteden HC,Aerts JG,Hegmans JP

更新日期：2010-08-30 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is associated with poorer outcomes in some cancers. Its effect on ovarian cancer is less clear. We consider the effect of DM on overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective cohort study of 215 patie...

journal_title：BMC cancer

authors： Akhavan S,Ghahghaei-Nezamabadi A,Modaresgilani M,Mousavi AS,Sepidarkish M,Tehranian A,Rezayof E

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Clinical trials where cancer patients were treated with protease inhibitors have suggested that the serine protease, prostasin, may act as a tumour suppressor. Prostasin is proteolytically activated by the serine protease, matriptase, which has a very high oncogenic potential. Prostasin is inhibited by prote...

journal_title：BMC cancer

authors： Selzer-Plon J,Bornholdt J,Friis S,Bisgaard HC,Lothe IM,Tveit KM,Kure EH,Vogel U,Vogel LK

更新日期：2009-06-25 00:00:00

abstract：BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...

journal_title：BMC cancer

authors： Inari H,Teruya N,Kishi M,Horii R,Akiyama F,Takahashi S,Ito Y,Ueno T,Iwase T,Ohno S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. METHOD:Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow ...

journal_title：BMC cancer

authors： Xiao H,He M,Xie G,Liu Y,Zhao Y,Ye X,Li X,Zhang M

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in distinct cancer entities can be determined by a comprehensive expression analysis of the 13 human AQPs....

journal_title：BMC cancer

authors： Warth A,Muley T,Meister M,Herpel E,Pathil A,Hoffmann H,Schnabel PA,Bender C,Buness A,Schirmacher P,Kuner R

更新日期：2011-05-06 00:00:00

abstract：BACKGROUND:Twist, a transcription factor of the basic helix-loop-helix class, is reported to regulate cancer metastasis. It is known to induce epithelial-mesenchymal transition (EMT). In this study, we evaluated the expression of twist and its effect on cell migration in hepatocellular carcinoma (HCC). METHODS:We exam...

journal_title：BMC cancer

authors： Matsuo N,Shiraha H,Fujikawa T,Takaoka N,Ueda N,Tanaka S,Nishina S,Nakanishi Y,Uemura M,Takaki A,Nakamura S,Kobayashi Y,Nouso K,Yagi T,Yamamoto K

更新日期：2009-07-18 00:00:00

abstract：BACKGROUND:Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to deve...

journal_title：BMC cancer

authors： Luo J,Liu P,Wang L,Huang Y,Wang Y,Geng W,Chen D,Bai Y,Yang Z

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Although Temozolomide is effective against glioblastoma, the prognosis remains dismal and new regimens with synergistic activity are sought for. METHODS:In this phase-I/II trial, pegylated liposomal doxorubicin (Caelyx, PEG-Dox) and prolonged administration of Temozolomide in addition to radiotherapy was in...

journal_title：BMC cancer

authors： Beier CP,Schmid C,Gorlia T,Kleinletzenberger C,Beier D,Grauer O,Steinbrecher A,Hirschmann B,Brawanski A,Dietmaier C,Jauch-Worley T,Kölbl O,Pietsch T,Proescholdt M,Rümmele P,Muigg A,Stockhammer G,Hegi M,Bogdahn U,Hau

更新日期：2009-09-02 00:00:00

abstract：BACKGROUND:Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric cancer and their clinicopathological and prognostic value were de...

journal_title：BMC cancer

authors： Gan L,He J,Zhang X,Zhang YJ,Yu GZ,Chen Y,Pan J,Wang JJ,Wang X

更新日期：2012-12-02 00:00:00

abstract：BACKGROUND:Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significanc...

journal_title：BMC cancer

authors： Song Y,Song S,Zhang D,Zhang Y,Chen L,Qian L,Shi M,Zhao H,Jiang Z,Guo N

更新日期：2006-12-28 00:00:00

abstract：BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...

journal_title：BMC cancer

authors： Humphries MP,Craig SG,Kacprzyk R,Fisher NC,Bingham V,McQuaid S,Murray GI,McManus D,Turkington RC,James J,Salto-Tellez M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet delivery, but self-guided interventions have shown limited efficacy. The aim of this study is to test t...

journal_title：BMC cancer

authors： Lyhne JD,Smith A'B,Frostholm L,Fink P,Jensen LH

更新日期：2020-03-16 00:00:00

abstract：BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangemen...

journal_title：BMC cancer

authors： Wang L,Sun Y,Sun Y,Meng L,Xu X

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast cancer is a highly heterogeneous disease, the responses of different patients to everolimus may ...

journal_title：BMC cancer

authors： Yi Z,Ma F,Liu B,Guan X,Li L,Li C,Qian H,Xu B

更新日期：2019-05-14 00:00:00

abstract：BACKGROUNDS:Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed promising results for gastric cancers. However, the influence of preoperative adverse events (AEs) on postoperative complications remains unknown. The aim of this study was to identify correlations between them. METHODS:Clinical data and l...

journal_title：BMC cancer

authors： Li SX,Seo SH,Choi YY,Nakagawa M,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 in CRC and the mechanism underlying that function is still unclear. METHODS:After analyzing the expression of miR-21 and Sec23A in CRC cell lines, we transfected the highest miR-21 e...

journal_title：BMC cancer

authors： Li C,Zhao L,Chen Y,He T,Chen X,Mao J,Li C,Lyu J,Meng QH

更新日期：2016-08-05 00:00:00

abstract：BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...

journal_title：BMC cancer

authors： Ehteda A,Galettis P,Pillai K,Morris DL

更新日期：2013-02-23 00:00:00

abstract：BACKGROUND:Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection of patients who might benefit form adjuvant chemotherapy (ACT). Presence of circulating tumor DNA (ctDNA) is indicative for MRD and has hi...

journal_title：BMC cancer

authors： Schraa SJ,van Rooijen KL,van der Kruijssen DEW,Rubio Alarcón C,Phallen J,Sausen M,Simmons J,Coupé VMH,van Grevenstein WMU,Elias S,Verkooijen HM,Laclé MM,Bosch LJW,van den Broek D,Meijer GA,Velculescu VE,Fijneman RJA,Vin

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such approach. Here we investigated the concordance between mutations found in the primary tumor and pancre...

journal_title：BMC cancer

authors： Choi MH,Mejlænder-Andersen E,Manueldas S,El Jellas K,Steine SJ,Tjensvoll K,Sætran HA,Knappskog S,Hoem D,Nordgård O,Hovland R,Molven A

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma (DLBCL) remains unconfirmed. This study aimed to identify the prognostic importance of H. pylori...

journal_title：BMC cancer

authors： Cheng Y,Xiao Y,Zhou R,Liao Y,Zhou J,Ma X

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gastric cancer remains controversial. METHODS:Major databases were systematically searched. The qua...

journal_title：BMC cancer

authors： Wu Z,Zhao J,Gao P,Song Y,Sun J,Chen X,Ma B,Wang Z

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk. METHODS:Fifty-five thousand nine hundred thirty-seven cases (all prostate canc...

journal_title：BMC cancer

authors： Beckmann K,Russell B,Josephs D,Garmo H,Haggstrom C,Holmberg L,Stattin P,Van Hemelrijck M,Adolfsson J

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect varies substantially among ...

journal_title：BMC cancer

authors： Tranberg M,Bech BH,Blaakær J,Jensen JS,Svanholm H,Andersen B

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression of several cancers such as breast cancer. Here, the consequence of NAMPT inhibition by miR-154 was ...

journal_title：BMC cancer

authors： Bolandghamat Pour Z,Nourbakhsh M,Mousavizadeh K,Madjd Z,Ghorbanhosseini SS,Abdolvahabi Z,Hesari Z,Ezzati Mobasser S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesized c-Met ...

journal_title：BMC cancer

authors： Park CH,Cho SY,Ha JD,Jung H,Kim HR,Lee CO,Jang IY,Chae CH,Lee HK,Choi SU

更新日期：2016-01-22 00:00:00