Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.

abstract：BACKGROUND:There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the abov...

journal_title：BMC cancer

authors： Zhao P,Chen Q,Lu W

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy...

journal_title：BMC cancer

authors： Vuolukka K,Auvinen P,Palmgren JE,Aaltomaa S,Kataja V

更新日期：2020-05-20 00:00:00

abstract：BACKGROUND:The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases...

journal_title：BMC cancer

authors： Henkens R,Delvenne P,Arafa M,Moutschen M,Zeddou M,Tautz L,Boniver J,Mustelin T,Rahmouni S

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:To characterize prognostic and risk factors of central nervous system (CNS) metastases in patients with epithelial ovarian cancer (EOC). METHODS:A retrospective analysis of Xijing Hospital electronic medical records was conducted to identify patients with pathologically confirmed EOC and CNS metastases. In ...

journal_title：BMC cancer

authors： Liu BL,Liu SJ,Baskys A,Cheng H,Han Y,Xie C,Song H,Li J,Xin XY

更新日期：2014-11-17 00:00:00

abstract：BACKGROUND:This study investigated whether patients with acquired haemolytic anaemia (AHA) would have elevated cancer risk including that for non-haematological solid tumours. We further examined whether the cancer risk would be different between patients with autoimmune type AHA (AIHA) and patients of non-AIHA. METHO...

journal_title：BMC cancer

authors： Kok VC,Sung FC,Kao CH,Lin CC,Tseng CH

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...

journal_title：BMC cancer

authors： Allen-Brady K,Camp NJ

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LBVI) including lymphatic (LVI) and blood (BVI) vessel invasion is a critical step in cancer metastasis. In breast cancer, the optimal detection method of LBVI remains unclear. This research aimed to compare the prognostic value of different assessments of the LVI and BVI in patients...

journal_title：BMC cancer

authors： Gujam FJ,Going JJ,Mohammed ZM,Orange C,Edwards J,McMillan DC

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...

journal_title：BMC cancer

authors： Matsumoto M,Seike M,Noro R,Soeno C,Sugano T,Takeuchi S,Miyanaga A,Kitamura K,Kubota K,Gemma A

更新日期：2015-04-09 00:00:00

abstract：BACKGROUND:Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for the treatment of advanced UC after failure of platinum-based chemotherapy. However, to our knowledge...

journal_title：BMC cancer

authors： Bordi P,Tiseo M,Baldari G,Buti S

更新日期：2016-08-12 00:00:00

abstract：BACKGROUND:Kv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multiforme (GBM) are lacking. METHODS:We analyzed the expression of Kv10.1 by immunohistochemistry in the...

journal_title：BMC cancer

authors： Martínez R,Stühmer W,Martin S,Schell J,Reichmann A,Rohde V,Pardo L

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a novel target for breast cancer treatment. The aim of this study is t...

journal_title：BMC cancer

authors： Johnston SJ,Ahmad D,Aleskandarany MA,Kurozumi S,Nolan CC,Diez-Rodriguez M,Green AR,Rakha EA

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...

journal_title：BMC cancer

authors： Oberste M,Schaffrath N,Schmidt K,Bloch W,Jäger E,Steindorf K,Hartig P,Joisten N,Zimmer P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CNB) or vacuum-assisted biopsy (VAB). A meta-analysis reported that 25.9% of invasive ductal carcinoma (IDC) cases are preoperat...

journal_title：BMC cancer

authors： Takada K,Kashiwagi S,Asano Y,Goto W,Morisaki T,Takahashi K,Fujita H,Takashima T,Tomita S,Hirakawa K,Ohira M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its u...

journal_title：BMC cancer

authors： Song Q,Chen Q,Wang Q,Yang L,Lv D,Jin G,Liu J,Li B,Fei X

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...

journal_title：BMC cancer

authors： Jeong S,Lee K,Wen X,Kim Y,Cho NY,Jang JJ,Kang GH

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported that NSAID consumption protected against breast cancer, while most cohort studies did not find this ef...

journal_title：BMC cancer

authors： Dierssen-Sotos T,Gómez-Acebo I,de Pedro M,Pérez-Gómez B,Servitja S,Moreno V,Amiano P,Fernandez-Villa T,Barricarte A,Tardon A,Diaz-Santos M,Peiro-Perez R,Marcos-Gragera R,Lope V,Gracia-Lavedan E,Alonso MH,Michelena-Echeves

更新日期：2016-08-20 00:00:00

abstract：BACKGROUND:Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progression of hormone-naïve, organ-confined tumors. In localized prostate c...

journal_title：BMC cancer

authors： Hsiao JJ,Ng BH,Smits MM,Wang J,Jasavala RJ,Martinez HD,Lee J,Alston JJ,Misonou H,Trimmer JS,Wright ME

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K ...

journal_title：BMC cancer

authors： Krone B,Kölmel KF,Grange JM

更新日期：2014-08-16 00:00:00

abstract：BACKGROUND:Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. ...

journal_title：BMC cancer

authors： Radoï L,Menvielle G,Cyr D,Lapôtre-Ledoux B,Stücker I,Luce D,ICARE Study Group.

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Primary treatment of carcinoma of the oro-/hypopharynx or larynx may consist of combined platinum-containing chemoradiotherapy. In order to improve clinical outcome (i.e. local control/overall survival), combined therapy is intensified by the addition of the EGFR inhibitor cetuximab (Erbitux®). Radiation the...

journal_title：BMC cancer

authors： Habl G,Jensen AD,Potthoff K,Uhl M,Hof H,Hajda J,Simon C,Debus J,Krempien R,Münter MW

更新日期：2010-11-26 00:00:00

abstract：BACKGROUND:Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors, notably ASF/SF2. The altered expression pattern of hnRNP A2/B1 and/or splicing variant B1 alone in ...

journal_title：BMC cancer

authors： Boukakis G,Patrinou-Georgoula M,Lekarakou M,Valavanis C,Guialis A

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. Notably, tumor-stroma signals affect the pattern of infiltrated immune cells and the profile of tumor-released cytokines. Among the known molecules that are engaged in stimulating the metastatic spread of t...

journal_title：BMC cancer

authors： Grum-Schwensen B,Klingelhöfer J,Beck M,Bonefeld CM,Hamerlik P,Guldberg P,Grigorian M,Lukanidin E,Ambartsumian N

更新日期：2015-02-12 00:00:00

abstract：BACKGROUND:The diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and CTSB was detected in biopsy tissues from nasopharyngeal carcinoma (NPC). However, whether CTSD and C...

journal_title：BMC cancer

authors： Tan G,Liu Q,Tang X,Kang T,Li Y,Lu J,Zhao X,Tang F

更新日期：2016-03-19 00:00:00

abstract：BACKGROUND:Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adverse events (IRAEs) can occur during treatment. These side effects occur due to stimulation of the i...

journal_title：BMC cancer

authors： Khaddour K,Singh V,Shayuk M

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Abnormal glucose and lipids levels may impact survival after breast cancer (BC) diagnosis, but their association to other causes of mortality such as cardiovascular (CV) disease may result in a competing risk problem. METHODS:We assessed serum glucose, triglycerides (TG) and total cholesterol (TC) measured ...

journal_title：BMC cancer

authors： Wulaningsih W,Vahdaninia M,Rowley M,Holmberg L,Garmo H,Malmstrom H,Lambe M,Hammar N,Walldius G,Jungner I,Coolen AC,Van Hemelrijck M

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:In Ethiopia, the incidence of new cases of breast cancer is currently increasing resulting to high rates of morbidity and mortality. Breast cancer is by far the most common cancer accounting for more than one out of three cancer cases in women and one out of every five in the general population. The study wa...

journal_title：BMC cancer

authors： Deressa BT,Cihoric N,Badra EV,Tsikkinis A,Rauch D

更新日期：2019-04-25 00:00:00

abstract：BACKGROUND:To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. METHODS:Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nati...

journal_title：BMC cancer

authors： Colonna M,Mitton N,Bossard N,Belot A,Grosclaude P,French Network of Cancer Registries (FRANCIM).

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global mediator. CASE PRESENTATIONS:We report a series of four patients, diagnosed with cutaneous T-cell ...

journal_title：BMC cancer

authors： Song JS,Tawa M,Chau NG,Kupper TS,LeBoeuf NR

更新日期：2017-03-16 00:00:00

abstract：BACKGROUND:CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and functional causality between CCR7 expression and lymph node metastasis in patients with esophageal squamous ...

journal_title：BMC cancer

authors： Irino T,Takeuchi H,Matsuda S,Saikawa Y,Kawakubo H,Wada N,Takahashi T,Nakamura R,Fukuda K,Omori T,Kitagawa Y

更新日期：2014-04-26 00:00:00