Metabolic complete response with vinflunine as second-line therapy in a kidney-transplanted patient with advanced urothelial carcinoma: a case report.

abstract：BACKGROUND:New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health. This paper reports on trends in the geographical mortality patterns of the most frequent cancers in Spain, over a period of 2...

journal_title：BMC cancer

authors： López-Abente G,Aragonés N,Pérez-Gómez B,Pollán M,García-Pérez J,Ramis R,Fernández-Navarro P

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare. CASE PRESENTATION:A 50 years-old woman was found to have a pelvic mass on transvaginal ultrasound...

journal_title：BMC cancer

authors： De Leo A,Nannini M,Dondi G,Santini D,Urbini M,Gruppioni E,De Iaco P,Perrone AM,Pantaleo MA

更新日期：2018-03-16 00:00:00

abstract：BACKGROUND:As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms responsible for ES metastasis remain poorly understood. In this study, we aimed to explore whether Wn...

journal_title：BMC cancer

authors： Jin Z,Zhao C,Han X,Han Y

更新日期：2012-10-18 00:00:00

abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...

journal_title：BMC cancer

authors： Glockzin G,Gerken M,Lang SA,Klinkhammer-Schalke M,Piso P,Schlitt HJ

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Ongoing improvements in technique and instruments for video-assisted thoracoscopic surgery (VATS) have made minimally-invasive uniportal VATS lobectomy a reality. However, the outcomes of the procedure are still under investigation, and at present, uniportal VATS lobectomy is performed infrequently at most h...

journal_title：BMC cancer

authors： Wang L,Liu D,Lu J,Zhang S,Yang X

更新日期：2017-01-25 00:00:00

abstract：BACKGROUND:Advances in the knowledge of renal neoplasms have demonstrated the implication of several proteases in their genesis, growth and dissemination. Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase with angiotensinase activity highly expressed in kidney tissues and its expression and activi...

journal_title：BMC cancer

authors： Blanco L,Sanz B,Perez I,Sánchez CE,Cándenas ML,Pinto FM,Gil J,Casis L,López JI,Larrinaga G

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Ramucirumab (RAM) with weekly paclitaxel (wPTX) is a standard second-line therapy for advanced or recurrent gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-PTX), an albumin-bound form of PTX, was developed to improve the therapeutic index of taxane treatment. However, the ABSOLUTE trial showed the...

journal_title：BMC cancer

authors： Hirata K,Hamamoto Y,Ando M,Imamura CK,Yoshimura K,Yamazaki K,Hironaka S,Muro K

更新日期：2020-06-12 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive of the primary brain tumors, with a grim prognosis despite intensive treatment. In the past decades, progress in research has not significantly increased overall survival rate. METHODS:The in vitro antineoplastic effect and mechanism of action of Casiopei...

journal_title：BMC cancer

authors： Trejo-Solís C,Jimenez-Farfan D,Rodriguez-Enriquez S,Fernandez-Valverde F,Cruz-Salgado A,Ruiz-Azuara L,Sotelo J

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the cancer. Here, we sought to identify a molecular signature based on S100A8 expression and to assess ...

journal_title：BMC cancer

authors： Kim SK,Kim EJ,Leem SH,Ha YS,Kim YJ,Kim WJ

更新日期：2010-01-25 00:00:00

abstract：BACKGROUND:In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherite...

journal_title：BMC cancer

authors： Neklason DW,Done MW,Sargent NR,Schwartz AG,Anton-Culver H,Griffin CA,Ahnen DJ,Schildkraut JM,Tomlinson GE,Strong LC,Miller AR,Stopfer JE,Burt RW

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer. METHODS:Patients with recur...

journal_title：BMC cancer

authors： Briasoulis E,Aravantinos G,Kouvatseas G,Pappas P,Biziota E,Sainis I,Makatsoris T,Varthalitis I,Xanthakis I,Vassias A,Klouvas G,Boukovinas I,Fountzilas G,Syrigos KN,Kalofonos H,Samantas E

更新日期：2013-05-29 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...

journal_title：BMC cancer

authors： Kelly-Morland C,Rudman S,Nathan P,Mallett S,Montana G,Cook G,Goh V

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemot...

journal_title：BMC cancer

authors： Kim B,Stephen SL,Hanby AM,Horgan K,Perry SL,Richardson J,Roundhill EA,Valleley EM,Verghese ET,Williams BJ,Thorne JL,Hughes TA

更新日期：2015-09-11 00:00:00

abstract：BACKGROUND:Along with the marked increase in early gastric cancer (EGC) in the Eastern countries, there has been an effort to adopt the sentinel node concept in EGC to preserve gastric function and reduce the occurrence of postoperative complications. Based on promising results from a previous quality control study, th...

journal_title：BMC cancer

authors： Park JY,Kim YW,Ryu KW,Nam BH,Lee YJ,Jeong SH,Park JH,Hur H,Han SU,Min JS,An JY,Hyung WJ,Cho GS,Jeong GA,Jeong O,Park YK,Jung MR,Yoon HM,Eom BW

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its fu...

journal_title：BMC cancer

authors： Benedicto A,Marquez J,Herrero A,Olaso E,Kolaczkowska E,Arteta B

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC. METHODS:We investigated SMAD4 status in PDAC by immunohistochemical methods to explore the relationshi...

journal_title：BMC cancer

authors： Wang Z,Li Y,Zhan S,Zhang L,Zhang S,Tang Q,Li M,Tan Z,Liu S,Xing X

更新日期：2019-11-04 00:00:00

abstract：BACKGROUND:Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not been evaluated. This study examines the chronological changes of gut microbiota i...

journal_title：BMC cancer

authors： Chua LL,Rajasuriar R,Lim YAL,Woo YL,Loke P,Ariffin H

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:The purpose of this case report is to describe a conjunctiva and eyelid Kaposi's sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection. CAS...

journal_title：BMC cancer

authors： Sousa Neves F,Braga J,Cardoso da Costa J,Sequeira J,Prazeres S

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) are both expressed by a number of malignant tumors, including those of the breast. In the latter, both behave as potent inhibitors of invasion. Nevertheless, the signaling pathways whereby the activated GnRH/GnRHR system exerts this effect have n...

journal_title：BMC cancer

authors： Aguilar-Rojas A,Huerta-Reyes M,Maya-Núñez G,Arechavaleta-Velásco F,Conn PM,Ulloa-Aguirre A,Valdés J

更新日期：2012-11-23 00:00:00

abstract：BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...

journal_title：BMC cancer

authors： Rot S,Kaune T,Taubert H,Greither T,Kotrba J,Güttler A,Wichmann H,Bilkenroth U,Wienke A,Al-Nawas B,Bache M,Vordermark D,Wickenhauser C,Bethmann D,Eckert AW,Kappler M

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...

journal_title：BMC cancer

authors： Ejegod DM,Rebolj M,Bonde J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) in patients with resectable thoracic esophageal squamo...

journal_title：BMC cancer

authors： Toyokawa T,Kubo N,Tamura T,Sakurai K,Amano R,Tanaka H,Muguruma K,Yashiro M,Hirakawa K,Ohira M

更新日期：2016-09-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC cancer

authors： Schiavone G,Epistolio S,Martin V,Molinari F,Barizzi J,Mazzucchelli L,Frattini M,Wannesson L

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:To identify and to assess factors enhancing or hindering the delivery of breast and cervical cancer screening services in Malawi with regard to accessibility, uptake, acceptability and effectiveness. METHODS:Systematic review of published scientific evidence. A search of six bibliographic databases and grey...

journal_title：BMC cancer

authors： Pittalis C,Panteli E,Schouten E,Magongwa I,Gajewski J

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Cancer stem cell (CSC) hypothesis has not been well demonstrated by the lack of the most convincing evidence concerning a single cell capable of giving rise to a tumor. The scarcity in quantity and improper approaches for isolation and purification of CSCs have become the major obstacles for great developmen...

journal_title：BMC cancer

authors： Li HZ,Yi TB,Wu ZY

更新日期：2008-05-14 00:00:00

abstract：BACKGROUND:Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment and highly specialized skill sets. METHODS:We have designed and developed an assay, CpGlobal, which ...

journal_title：BMC cancer

authors： Anisowicz A,Huang H,Braunschweiger KI,Liu Z,Giese H,Wang H,Mamaev S,Olejnik J,Massion PP,Del Mastro RG

更新日期：2008-08-03 00:00:00

abstract：BACKGROUND:The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). METHODS:Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy. Expression of hepcidin mRNA was evaluated by real-time PCR, and compared in tumors differ...

journal_title：BMC cancer

authors： Kijima H,Sawada T,Tomosugi N,Kubota K

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...

journal_title：BMC cancer

authors： Borch KB,Braaten T,Lund E,Weiderpass E

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

journal_title：BMC cancer

authors： Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and...

journal_title：BMC cancer

authors： Olsson Möller U,Rydén L,Malmström M

更新日期：2020-05-29 00:00:00