Abstract:
BACKGROUND:This study investigated whether patients with acquired haemolytic anaemia (AHA) would have elevated cancer risk including that for non-haematological solid tumours. We further examined whether the cancer risk would be different between patients with autoimmune type AHA (AIHA) and patients of non-AIHA. METHODS:Using nationwide population-based insurance claims data of Taiwan we identified a cohort of patients with AHA with no pre-existing cancer, (n = 3902) and a comparison cohort (n = 39020) without AHA, frequency-matched by gender, age, urbanization of residency and diagnosis date. Incidence and Cox method estimated adjusted hazard ratios (aHR) of cancers controlling covariates by the end of 2010 were calculated. Risks between patients with AIHA and non-AIHA were compared. Sensitivity analysis was carried out to measure the risk of cancer between patients with and without AHA by follow-up years. RESULTS:Patients with AHA had a 90% greater incidence of cancer than controls, with an aHR of 1.78 (95% confidence interval (CI), 1.50-2.12)]. The overall aHRs of cancer for patients with AIHA and non-AIHA were 2.01 (95% CI, 1.56-2.59) and 1.87 (95% CI, 1.53-2.29), respectively, compared with the comparison cohort. The aHRs for lymphatic-haematopoietic malignancy were 19.5 and 9.59 in the AIHA and non-AIHA cohorts, respectively. No hazard of colorectal, lung, liver or breast cancer was significant. CONCLUSIONS:There is a near 2-fold elevated risk for subsequent cancer in patients with AHA, particularly for lymphatic-haematopoietic malignancy, which is much greater for patients with AIHA than non-AIHA. These findings can help clinicians decide patient-centred personalized long-term management.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Kok VC,Sung FC,Kao CH,Lin CC,Tseng CHdoi
10.1186/s12885-016-2098-3subject
Has Abstractpub_date
2016-02-04 00:00:00pages
57issn
1471-2407pii
10.1186/s12885-016-2098-3journal_volume
16pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Circulating tumor cells (CTCs) are detectable in peripheral blood of metastatic breast cancer patients (MBC). In this paper we evaluate a new CTC separation method based on a combination of anti-EpCAM- and anti-cytokeratin magnetic cell separation with the aim to improve CTC detection with low target antigen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-206
更新日期:2012-05-30 00:00:00
abstract:BACKGROUND:Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). METHODS:All eligible studies were found by searching PubMed, Web of Science and EMBASE, and survival resu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07751-y
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an important role in tumor-associated angiogenesis. However, the effects of simultaneously targeting on VE...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2834-8
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:Previous studies on bladder cancer have shown nodal involvement to be an independent indicator of prognosis and survival. This study aimed at developing an objective method for detection of nodal metastasis from molecular profiles of primary urothelial carcinoma tissues. METHODS:The study included primary b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-159
更新日期:2006-06-16 00:00:00
abstract:BACKGROUND:Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-85
更新日期:2009-03-17 00:00:00
abstract:BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07235-z
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophag...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-156
更新日期:2007-08-10 00:00:00
abstract:BACKGROUND:Epidemiological studies show that cigarette smoking increase the risk of nasopharyngeal carcinoma (NPC), however, whether other common, potentially adverse household inhalants increase NPC risk remains uncertain. METHODS:We conducted a large case-control study to explore the effects of household inhalants, ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2035-x
更新日期:2015-12-29 00:00:00
abstract:BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3412-4
更新日期:2017-06-19 00:00:00
abstract:BACKGROUND:Breast cancer places a heavy burden on the Australian healthcare system, but information about the actual number of women living with breast cancer and their current or future health service needs is limited. We used existing population-based data and innovative statistical methods to address this critical r...
journal_title:BMC cancer
pub_type: 历史文章,杂志文章
doi:10.1186/1471-2407-14-936
更新日期:2014-12-11 00:00:00
abstract:BACKGROUND:Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants. Positive correlation between the degree of AhR overexpression and states ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-234
更新日期:2009-07-15 00:00:00
abstract:BACKGROUND:The associations between microRNAs and lung cancer have received increasing attention. This study assess the association between polymorphisms in miR-135a-2, miR-219-2 and miR-211 genes and the risk of lung cancer, as well as the gene-environment interaction between these polymorphisms and cooking oil fume e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2784-1
更新日期:2016-09-23 00:00:00
abstract:BACKGROUND:FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been reported in a variety of human tumour entities. FOXM1 is a gene of interest because recently chemical in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-42
更新日期:2008-02-06 00:00:00
abstract:BACKGROUND:Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to be functional in part. Yet the importance of these RNAs especially for higher biological functions ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6338-1
更新日期:2019-12-03 00:00:00
abstract:BACKGROUND:This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. METHODS:In this retrospective case series, intravitreal chemotherapy-assisted en...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07314-1
更新日期:2020-08-26 00:00:00
abstract:BACKGROUNDS:Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows phenotypic changes (population changes) upon differentiation of CSC during culture and can be used for s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1297-7
更新日期:2015-04-11 00:00:00
abstract:BACKGROUND:Myopericytoma is a rare and usually benign tumor, which is even rarer if it occurs in the liver and stomach space. Previous reports of myopericytoma were mostly related to its pathological manifestations, while imaging reports were rare. Here, we report the computed tomography (CT), computed tomography angio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3146-3
更新日期:2017-02-20 00:00:00
abstract:BACKGROUND:Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-365
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:Currently, clinical studies on the prognosis of prostate cancer (PC) taking aspirin were developing, but the precise mechanism of aspirin on tumor cells was still unclear. In addition, the conclusion that aspirin can improve the prognosis of PC patients continues to be controversial. Therefore, we collected ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-019-6415-5
更新日期:2019-12-05 00:00:00
abstract:BACKGROUND:Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-13-565
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. METHODS:A total of 133 patients with anaplastic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-450
更新日期:2009-12-18 00:00:00
abstract:BACKGROUND:Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in patients with metastatic/relapsed STS following failure of prior chemotherapy by examining data colle...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1182-4
更新日期:2015-03-25 00:00:00
abstract:BACKGROUND:Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, HPV-anal cancer and oropharyngeal cancers are rising. To help ascertain a useful PCR detection protoc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-440
更新日期:2009-12-15 00:00:00
abstract:BACKGROUND:The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. METHODS:We used high-throughp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3948-3
更新日期:2018-01-10 00:00:00
abstract:BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-179
更新日期:2007-09-20 00:00:00
abstract:BACKGROUND:Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5572-x
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-214
更新日期:2007-11-19 00:00:00
abstract::ABSTRACT: BACKGROUND: The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender differences in these respects. METHODS: A questionnaire-based survey of PHC patients in t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-408
更新日期:2011-09-25 00:00:00
abstract:BACKGROUND:In Brazil, the rate of cervical cancer remains high despite the availability of screening programs. With ongoing vaccine development and implementation, information on the prevalence of specific HPV types is needed, particularly among high-risk populations, such as HIV-infected women. METHODS:We performed a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1486-4
更新日期:2015-06-23 00:00:00
abstract:BACKGROUND:Cancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs for the 21 most prevalent cancer sites, and remaining tumour sites combined, in Ontario, Canada. M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2835-7
更新日期:2016-10-18 00:00:00