Abstract:
BACKGROUND:Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants. Positive correlation between the degree of AhR overexpression and states of increasing transformation of mammary epithelial cells appears to occur in the absence of any exogenous AhR ligands. These observations have raised many questions such as why and how AhR is overexpressed in breast cancer and its physiological roles in the progression to advanced carcinogenic transformation. To address those questions, we hypothesized that AhR overexpression occurs in cells experiencing deficiencies in normally required estrogen receptor (ER) signaling, and the basic role of AhR in such cases is to guide the affected cells to develop orchestrated cellular changes aimed at substituting the normal functions of ER. At the same time, the AhR serves as the mediator of the cell survival program in the absence of ER signaling. METHODS:We subjected two lines of Michigan Cancer Foundation (MCF) mammary epithelial cells to 3 different types ER interacting agents for a number of passages and followed the changes in the expression of AhR mRNA. The resulting sublines were analyzed for phenotypical changes and unique molecular characteristics. RESULTS:MCF10AT1 cells continuously exposed to 17-beta-estradiol (E2) developed sub-lines that show AhR overexpression with the characteristic phenotype of increased proliferation, and distinct resistance to apoptosis. When these chemically selected cell lines were treated with a specific AhR antagonist, 3-methoxy-4-nitroflavone (MNF), both of the above abnormal cellular characteristics disappeared, indicating the pivotal role of AhR in expressing those cellular phenotypes. The most prominent molecular characteristics of these AhR overexpressing MCF cells were found to be overexpression of ErbB2 and COX-2. Furthermore, we could demonstrate that suppression of AhR functions through anti-AhR siRNA or MNF causes the recovery of ERalpha functions. CONCLUSION:One of the main causes for AhR overexpression in these MCF breast cancer cells appears to be the loss of ERalpha functions. This phenomenon is likely to be based on the mutually antagonistic relationship between ER and AhR.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Wong PS,Li W,Vogel CF,Matsumura Fdoi
10.1186/1471-2407-9-234subject
Has Abstractpub_date
2009-07-15 00:00:00pages
234issn
1471-2407pii
1471-2407-9-234journal_volume
9pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5' untrans...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3595-8
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution, workplace exposures and history of previous respiratory diseases with special consideration given ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-285
更新日期:2010-06-14 00:00:00
abstract:BACKGROUND:Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α), transcriptional regulators of several genes involved in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-293
更新日期:2012-07-17 00:00:00
abstract:BACKGROUND:The differentiation of pancreatic ductal adenocarcinoma (PDAC) could be associated with prognosis and may influence the choices of clinical management. No applicable methods could reliably predict the tumor differentiation preoperatively. Thus, the aim of this study was to compare the metabonomic profiling o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3703-9
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) comprises a heterogeneous group of diseases which are generally associated with poor prognosis. Up to now, no targeted treatment beyond anti-VEGF therapy has been approved for TNBC and cytotoxic agents remain the mainstay of treatment. Ixazomib is a selective and reversib...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4979-0
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Oesophageal squamous cell carcinoma (OSCC) is a major health burden in Sub-Saharan Africa, and novel chemotherapies are urgently required to combat this disease. The heat shock protein 90 (HSP90) inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) has previously been proposed as a possible candidate ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-334
更新日期:2014-05-15 00:00:00
abstract:BACKGROUND:There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). METHODS:Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3030-6
更新日期:2017-01-04 00:00:00
abstract:BACKGROUND:The radiopharmaceutical (131)I-meta-iodobenzylguanidine ((131)I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from (131)I-MIBG is likely to be obtained by its combination with chemotherapy. We previously reported enhanced antitumour efficacy of (131)I-MIBG by inhibit...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2656-8
更新日期:2016-08-11 00:00:00
abstract:BACKGROUND:Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear. METHODS:The Cancer Genome Atlas (TCGA) database indicated that a high level of HOXB4 in OV was correlated with poor prognosis. The biological functions ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06725-4
更新日期:2020-03-16 00:00:00
abstract:BACKGROUND:Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this moment, there are no specific treatment recommendations for patients with limited nodal recurrences a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06911-4
更新日期:2020-05-12 00:00:00
abstract:BACKGROUND:Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. METHO...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1512-6
更新日期:2015-07-04 00:00:00
abstract:BACKGROUND:Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2701-7
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This study investigated the role of hyaluronan (HA) and a potential link between the HA-CD44 pathway and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-476
更新日期:2013-10-14 00:00:00
abstract:BACKGROUND:Persistent high-risk human papillomavirus (HPV) infection is correlated with an increased risk of developing intraepithelial lesion or malignancy (NILM). The aims of the current study is to establish a method named BioPerfectus Multiplex Real Time (BMRT) HPV assay for simultaneous typing and quantifying HPVs...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1874-9
更新日期:2015-11-06 00:00:00
abstract:BACKGROUND:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. Th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-108
更新日期:2008-04-18 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ≥65 years marks the potential for hypomethylating agents in elderly AML. Nevertheless the situation ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-015-1432-5
更新日期:2015-05-26 00:00:00
abstract:BACKGROUND:The use of computerized systems to support evidence-based practice is commonplace in contemporary medicine. Despite the prolific use of electronic support systems there has been relatively little research on the uptake of web-based systems in the oncology setting. Our objective was to examine the uptake of a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-112
更新日期:2013-03-12 00:00:00
abstract:BACKGROUND:Despite being a mainstay for treating superficial bladder carcinoma and a promising agent for interstitial cystitis, the precise mechanism of Bacillus Calmette-Guerin (BCG) remains poorly understood. It is particularly unclear whether BCG is capable of altering gene expression beyond its well-recognized pro-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-204
更新日期:2007-11-02 00:00:00
abstract:BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-566
更新日期:2010-10-19 00:00:00
abstract:BACKGROUND:Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement membrane breakdown is one of the hallmarks of invasion; therefore...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3660-3
更新日期:2017-10-04 00:00:00
abstract:BACKGROUND:Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney cancer is rising across the sexes in some of these countries, a trend which may possibly reflect the ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-293
更新日期:2008-10-09 00:00:00
abstract:BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-017-3485-0
更新日期:2017-07-18 00:00:00
abstract:BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-612
更新日期:2010-11-08 00:00:00
abstract:BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2869-x
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival rates of only 50-60%. Neo-adjuvant and adjuvant chemotherapy (CTX) has been applied to achieve pre-...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-510
更新日期:2011-12-07 00:00:00
abstract:BACKGROUND:Microarray gene-profiling of invasive breast cancer has identified different subtypes including luminal A, luminal B, HER2-overexpressing and basal-like groups. Basal-like invasive breast cancer is associated with a worse prognosis. However, the prognosis of basal-like ductal carcinoma in situ (DCIS) is stil...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-653
更新日期:2010-11-30 00:00:00
abstract:BACKGROUND:Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. METHODS:PRL-3 genomic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-122
更新日期:2011-04-06 00:00:00
abstract:BACKGROUND:The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX). METHODS:Genomic DNA was isolated from who...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-43
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, risk stratification and prognostication. However, the genetic mechanisms that give rise to ALL remain p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6709-7
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-90
更新日期:2012-03-19 00:00:00