Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells.

abstract：BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...

journal_title：BMC cancer

authors： Chatterjee A,Mambo E,Zhang Y,Deweese T,Sidransky D

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:Excision repair cross-complementing group 2 (ERCC2) plays important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of ERCC2 gene are suspected to influence the risks of oral cancer. We performed a meta-analysis to systematically summarize the possible association of ERC...

journal_title：BMC cancer

authors： Zhang E,Cui Z,Xu Z,Duan W,Huang S,Tan X,Yin Z,Sun C,Lu L

更新日期：2013-12-12 00:00:00

abstract：BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...

journal_title：BMC cancer

authors： Matsushita J,Okamura K,Nakabayashi K,Suzuki T,Horibe Y,Kawai T,Sakurai T,Yamashita S,Higami Y,Ichihara G,Hata K,Nohara K

更新日期：2018-03-22 00:00:00

abstract：:Following publication of the original article [1], the authors notified us of a misleading data presentation in Table 4. ...

journal_title：BMC cancer

authors： Martínez-González NA,Neuner-Jehle S,Plate A,Rosemann T,Senn O

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether th...

journal_title：BMC cancer

authors： Liu C,Lu P,Lu Y,Xu H,Wang S,Chen J

更新日期：2007-10-24 00:00:00

abstract：BACKGROUND:Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is k...

journal_title：BMC cancer

authors： Cowman S,Fan YN,Pizer B,Sée V

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement membrane breakdown is one of the hallmarks of invasion; therefore...

journal_title：BMC cancer

authors： Dykes SS,Steffan JJ,Cardelli JA

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:The cost-effectiveness of human papillomavirus (HPV) vaccination in women pre-sexual debut has been demonstrated in many countries. This study aimed to estimate the cost-effectiveness of a 3-dose bivalent HPV vaccination at ages 12 to 55 year in both rural and urban settings in China. METHODS:The Markov coh...

journal_title：BMC cancer

authors： Liu YJ,Zhang Q,Hu SY,Zhao FH

更新日期：2016-02-26 00:00:00

abstract：BACKGROUND:Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regime...

journal_title：BMC cancer

authors： Jensen AD,Krauss J,Potthoff K,Desta A,Habl G,Mavtratzas A,Windemuth-Kiesselbach C,Debus J,Münter MW

更新日期：2011-05-19 00:00:00

abstract：BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochr...

journal_title：BMC cancer

authors： Sun Z,Lan X,Xu S,Li S,Xi Y

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objec...

journal_title：BMC cancer

authors： Wang L,Wang R,Pan Y,Sun Y,Zhang J,Chen H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence major emphasis is being laid on identification of novel molecular targets and development of multi-ta...

journal_title：BMC cancer

authors： Macha MA,Matta A,Chauhan S,Siu KM,Ralhan R

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:Humans are exposed to an array of both harmful and beneficial hormonally active compounds in the environment and through diet. Two such chemicals are Bisphenol A (BPA), a plasticizer, and genistein, a component of soy. Prepubertal exposure to BPA increased mammary carcinogenesis, while genistein suppressed c...

journal_title：BMC cancer

authors： Wang J,Jenkins S,Lamartiniere CA

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported the correlation between the prognosis of COAD and the immune system. The current study aimed to deve...

journal_title：BMC cancer

authors： Luo J,Liu P,Wang L,Huang Y,Wang Y,Geng W,Chen D,Bai Y,Yang Z

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Neoadjuvant systemic therapy (NST) is increasingly used in the treatment of breast cancer, yet it is clear that there is significant geographical variation in its use in the UK. This study aimed to examine stated practice across UK breast units, in terms of indications for use, radiological monitoring, patho...

journal_title：BMC cancer

authors： Whitehead I,Irwin GW,Bannon F,Coles CE,Copson E,Cutress RI,Dave RV,Gardiner MD,Grayson M,Holcombe C,Irshad S,O'Brien C,O'Connell RL,Palmieri C,Shaaban AM,Sharma N,Singh JK,Potter S,McIntosh SA,NeST Study Research Co

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...

journal_title：BMC cancer

authors： Call J,Walentas CD,Eickhoff JC,Scherzer N

更新日期：2012-03-19 00:00:00

abstract：BACKGROUND:Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion of lung cancer patients (~ 30%). Once diagnosed, patients have a poor prognosis surviving typically ...

journal_title：BMC cancer

authors： Shah N,Liu Z,Tallman RM,Mohammad A,Sprowls SA,Saralkar PA,Vickers SD,Pinti MV,Gao W,Lockman PR

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Peritoneal dissemination is the most common type of recurrence in advanced gastric cancer. The main mechanism is thought to be via the exfoliation of free cancer cells (FCCs) from tumor in the gastric serosa. The frequency of recurrence thus increases once the tumor cells penetrate the serosa. However, this ...

journal_title：BMC cancer

authors： Huang B,Sun Z,Wang Z,Lu C,Xing C,Zhao B,Xu H

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:In this era of oxaliplatin-based adjuvant therapy, the optimal sequence in which chemoradiotherapy should be administered for pathological stage N2 rectal cancer is unknown. The aim of this study was to investigate this sequence. METHODS:In the primary adjuvant concurrent chemoradiotherapy (A-CRT) group (n ...

journal_title：BMC cancer

authors： Feng YR,Jin J,Ren H,Wang X,Wang SL,Wang WH,Song YW,Liu YP,Tang Y,Li N,Liu XF,Fang H,Yu ZH,Li YX

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions in 109 cervical cancer patients. METHODS:We used immunohistochemistry of formalin-fixed, paraffin...

journal_title：BMC cancer

authors： Arellano-Llamas A,Garcia FJ,Perez D,Cantu D,Espinosa M,De la Garza JG,Maldonado V,Melendez-Zajgla J

更新日期：2006-10-26 00:00:00

abstract：BACKGROUND:High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia prom...

journal_title：BMC cancer

authors： Zhang L,Huang G,Li X,Zhang Y,Jiang Y,Shen J,Liu J,Wang Q,Zhu J,Feng X,Dong J,Qian C

更新日期：2013-03-09 00:00:00

abstract：BACKGROUND:Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct molecular features compared to metastases of known origin. METHODS:Employing genome wide transcripto...

journal_title：BMC cancer

authors： Vikeså J,Møller AK,Kaczkowski B,Borup R,Winther O,Henao R,Krogh A,Perell K,Jensen F,Daugaard G,Nielsen FC

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to be functional in part. Yet the importance of these RNAs especially for higher biological functions ...

journal_title：BMC cancer

authors： Smolander J,Stupnikov A,Glazko G,Dehmer M,Emmert-Streib F

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:The aim of the trial was to compare two active adjuvant chemotherapy regimens in patients with early stage colorectal cancer (CRC). METHODS:Patients were assigned to oxaliplatin, leucovorin and 5-FU for 12 cycles (group A, FOLFOX6) or oxaliplatin and capecitabine for eight cycles (group B, CAPOX). Primary e...

journal_title：BMC cancer

authors： Pectasides D,Karavasilis V,Papaxoinis G,Gourgioti G,Makatsoris T,Raptou G,Vrettou E,Sgouros J,Samantas E,Basdanis G,Papakostas P,Bafaloukos D,Kotoula V,Kalofonos HP,Scopa CD,Pentheroudakis G,Fountzilas G

更新日期：2015-05-10 00:00:00

abstract：BACKGROUND:The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are ...

journal_title：BMC cancer

authors： Hughes B,Yip D,Goldstein D,Waring P,Beshay V,Chong G

更新日期：2004-10-09 00:00:00

abstract：BACKGROUND:Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and par...

journal_title：BMC cancer

authors： Haffner MC,Petridou B,Peyrat JP,Révillion F,Müller-Holzner E,Daxenbichler G,Marth C,Doppler W

更新日期：2007-07-25 00:00:00

abstract：BACKGROUND:Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 protein overexpression, a second line gene amplification test is generally deemed necessary for cases ...

journal_title：BMC cancer

authors： Moelans CB,de Weger RA,Ezendam C,van Diest PJ

更新日期：2009-01-05 00:00:00

abstract：BACKGROUND:Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and ...

journal_title：BMC cancer

authors： Plummer HK 3rd,Dhar MS,Cekanova M,Schuller HM

更新日期：2005-08-18 00:00:00

abstract：BACKGROUND:Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the androgen receptor (AR) and progesterone receptor (PgR) are expressed in MBC. AR activation in breas...

journal_title：BMC cancer

authors： Takuwa H,Tsuji W,Shintaku M,Yotsumoto F

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increase...

journal_title：BMC cancer

authors： Guinan EM,Hussey J,McGarrigle SA,Healy LA,O'Sullivan JN,Bennett K,Connolly EM

更新日期：2013-03-21 00:00:00