Abstract:
BACKGROUND:It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in patients with HER2-negative metastatic breast cancer. METHODS:We searched Pubmed, Embase, and Cochrane Library Central Resister of Controlled Trials through were July 2019 for randomized controlled trials that evaluated the efficacy of bevacizumab plus chemotherapy in HER2-negative metastatic breast cancer. Data on included study characteristics, outcomes, and risk of bias were abstracted by two reviewers. RESULTS:A total of 16 RCT studies involving 5689 patients were included. The results showed that bevacizumab (Bev) - taxanes (Tax) - capecitabine (Cap) has highest-ranking and is probably more effective for prolonging progression-free survival (PFS) than Tax, Cap, Bev-Tax and Bev-Cap, which was no convincing differences among Bev-Cap-vinorelbine, Bev-Tax-everolimus, Bev-Tax-trebananib, Bev-exemestane, Bev-Cap-cyclophosphamide in Bev-containing regimens. For overall response rate (ORR), Bev-Tax-Cap is superior to Tax, Cap and Bev-Cap, while Bev-Tax-trebananib is superior to Cap. The cumulative probability ranking showed that Bev-Tax-Cap or Bev-Tax-trebananib may have best pathological response rate in HER2-negative metastatic breast cancer. CONCLUSION:Our results provide moderate quality evidence that bevacizumab-taxanes-capecitabine maybe the most effective bevacizumab plus chemotherapy on PFS and ORR in HER2-negative metastatic breast cancer, however it should be also considered that bevacizumab may add toxicity to chemotherapy and whether improve overall survival (OS) or not.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Sun Z,Lan X,Xu S,Li S,Xi Ydoi
10.1186/s12885-020-6674-1subject
Has Abstractpub_date
2020-03-04 00:00:00pages
180issue
1issn
1471-2407pii
10.1186/s12885-020-6674-1journal_volume
20pub_type
杂志文章,meta分析相关文献
BMC CANCER文献大全abstract:BACKGROUND:In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely undiscovered. This study aims to evaluate the role of a novel circRNAs and related molecular mechan...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6269-x
更新日期:2019-11-08 00:00:00
abstract:BACKGROUND:The purpose of this case report is to describe a conjunctiva and eyelid Kaposi's sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection. CAS...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4611-3
更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of special interest for the treatment of deregulated androgen receptor(AR)-signaling...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-130
更新日期:2012-03-30 00:00:00
abstract:BACKGROUND:Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involved in human cancer. However, there is limited information regarding the clinical significance of cyt...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-178
更新日期:2009-06-09 00:00:00
abstract:BACKGROUND:Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their metastatic disease. MET...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-820
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as first-line palliative combination chemotherapy. We also analyzed the predictive or prognostic value of...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-148
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of breast cancer, without tumor-specific treatment options and accounts for 15% of all types of breast ca...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-120
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:Peritoneal dissemination is the most common type of recurrence in advanced gastric cancer. The main mechanism is thought to be via the exfoliation of free cancer cells (FCCs) from tumor in the gastric serosa. The frequency of recurrence thus increases once the tumor cells penetrate the serosa. However, this ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-57
更新日期:2013-02-04 00:00:00
abstract:BACKGROUND:As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms responsible for ES metastasis remain poorly understood. In this study, we aimed to explore whether Wn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-480
更新日期:2012-10-18 00:00:00
abstract:BACKGROUND:Resilience has been linked to psychological adaptation to many challenging life events. The present study aims to explore the level of resilience in oral cancer patients and the key factors associated with resilience, and to evaluate the relationship between resilience and anxiety. METHODS:A multiple center...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-019-5679-0
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Deaf people represent 0.1% of the French population and their access to public health campaigns is limited due to their frequent illiteracy and the infrequent use of sign language in campaigns. There is also a lack of general health knowledge in spite of the existence of French Deaf Care Units (UASS). The ai...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3972-3
更新日期:2018-01-23 00:00:00
abstract:BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07698-0
更新日期:2020-12-02 00:00:00
abstract:BACKGROUND:The prevalence of patients with gastrointestinal stromal tumourgst (GIST) who fail currently available treatments imatinib and sunitinib (third-line treatment-eligible GIST) is unknown, but is expected to be below an ultra-orphan disease threshold of 2/100,000 population used in England and Wales. Our study ...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/1471-2407-14-364
更新日期:2014-05-24 00:00:00
abstract:BACKGROUND:Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial. In this study we aimed to determine the expression of these enzymes relatively to the expres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4508-1
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ≥65 years marks the potential for hypomethylating agents in elderly AML. Nevertheless the situation ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-015-1432-5
更新日期:2015-05-26 00:00:00
abstract:BACKGROUND:Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and JAK2 are critical for inflamm...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-018-5045-7
更新日期:2018-11-19 00:00:00
abstract:BACKGROUND:The main aim of this study is to estimate the rate of false negative and true IC on the Program for the Early Detection of Breast Cancer (PEDBC) run by the Girona Health Region (GHR) and compare the clinicopathological characteristics of these tumors with those detected within the same program. METHODS:A re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-558
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This in vitro study, for the first ti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-441
更新日期:2010-08-19 00:00:00
abstract:BACKGROUND:CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 expression in tumors has been discussed, but hepatocellular carcinoma (HCC) has not been included in these ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3460-9
更新日期:2017-07-07 00:00:00
abstract:BACKGROUND:Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mortality. The Sept9 DNA-methylation assay is among the most well studied blood-based screening markers...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1832-6
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in human pancreatic carcinomas. METHODS:In this study, we established a MBD1-knock-down pancreatic cancer ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-121
更新日期:2008-04-29 00:00:00
abstract:BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06987-y
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is sti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6482-7
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:There are large ethnic differences in cervical cancer survival in New Zealand that are only partly explained by stage at diagnosis. We investigated the association of comorbidity with cervical cancer survival, and whether comorbidity accounted for the previously observed ethnic differences in survival. METH...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-132
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07350-x
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcino...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-30
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to investigate the association between metformin use and risk and prognosis of patients with EC. METHODS:...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12885-018-4334-5
更新日期:2018-04-18 00:00:00
abstract:BACKGROUND:Significant progress in treatment of metastatic castration resistant prostate cancer (mCRPC) has been made. Biomarkers to tailor therapy are scarce. To facilitate decision-making we evaluated dynamic changes of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and prostate specific antigen (PSA) under ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2260-y
更新日期:2016-03-14 00:00:00
abstract:BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4475-6
更新日期:2018-05-11 00:00:00
abstract::Following publication of the original article [1], the authors reported that the incorrect Fig. 2A was published in the article. The recovery times required to achieve a normal neutrophil count was omitted. The corrected Fig. 2 is given below. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-5626-0
更新日期:2019-05-23 00:00:00