The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation.

abstract：BACKGROUND:The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy. METHODS:Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrol...

journal_title：BMC cancer

authors： Liu WS,Hsin CH,Chou YH,Liu JT,Wu MF,Tseng SW,Lee JK,Tseng HC,Wang TH,Su MC,Lee H

更新日期：2010-03-18 00:00:00

abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...

journal_title：BMC cancer

authors： Glockzin G,Gerken M,Lang SA,Klinkhammer-Schalke M,Piso P,Schlitt HJ

更新日期：2014-11-04 00:00:00

abstract：BACKGROUND:Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion of lung cancer patients (~ 30%). Once diagnosed, patients have a poor prognosis surviving typically ...

journal_title：BMC cancer

authors： Shah N,Liu Z,Tallman RM,Mohammad A,Sprowls SA,Saralkar PA,Vickers SD,Pinti MV,Gao W,Lockman PR

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. METHODS:A total of 133 patients with anaplastic a...

journal_title：BMC cancer

authors： Park CK,Lee SH,Han JH,Kim CY,Kim DW,Paek SH,Kim DG,Heo DS,Kim IH,Jung HW

更新日期：2009-12-18 00:00:00

abstract：BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...

journal_title：BMC cancer

authors： Shibata MA,Morimoto J,Shibata E,Kurose H,Akamatsu K,Li ZL,Kusakabe M,Ohmichi M,Otsuki Y

更新日期：2010-10-19 00:00:00

abstract：BACKGROUND:Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor signaling cascades are kn...

journal_title：BMC cancer

authors： Pignochino Y,Dell'Aglio C,Inghilleri S,Zorzetto M,Basiricò M,Capozzi F,Canta M,Piloni D,Cemmi F,Sangiolo D,Gammaitoni L,Soster M,Marchiò S,Pozzi E,Morbini P,Luisetti M,Aglietta M,Grignani G,Stella GM

更新日期：2015-05-08 00:00:00

abstract：BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...

journal_title：BMC cancer

authors： Matsumoto M,Seike M,Noro R,Soeno C,Sugano T,Takeuchi S,Miyanaga A,Kitamura K,Kubota K,Gemma A

更新日期：2015-04-09 00:00:00

abstract：BACKGROUND:Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers. In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and ...

journal_title：BMC cancer

authors： Sasi W,Jiang WG,Sharma A,Mokbel K

更新日期：2010-04-30 00:00:00

abstract：BACKGROUND:Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer p...

journal_title：BMC cancer

authors： Vidlickova I,Dequiedt F,Jelenska L,Sedlakova O,Pastorek M,Stuchlik S,Pastorek J,Zatovicova M,Pastorekova S

更新日期：2016-03-19 00:00:00

abstract：BACKGROUND:CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumulating data have shown that CD73 is a key regulatory molecule involved in cancer growth and metastasi...

journal_title：BMC cancer

authors： Gao ZW,Wang HP,Lin F,Wang X,Long M,Zhang HZ,Dong K

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. SFRP1 (the secreted frizzled-related protein 1), a putative tumor suppressor gene mapped onto chromosome 8p12-p11.1, the frequent loss of heterozygosity (LOH) region in human HCC, encodes a Wingless-type (Wnt) signaling antagonist...

journal_title：BMC cancer

authors： Huang J,Zhang YL,Teng XM,Lin Y,Zheng DL,Yang PY,Han ZG

更新日期：2007-07-12 00:00:00

abstract：BACKGROUND:Salivary gland cancer (SGC) is one of the common malignancies of the head and neck area. It develops in the minor and major salivary glands and sometimes metastasizes to other organs, particularly to the lungs. Inhibitors of differentiation (Id) proteins are negative regulators of basic helix-loop-helix tran...

journal_title：BMC cancer

authors： Sumida T,Murase R,Onishi-Ishikawa A,McAllister SD,Hamakawa H,Desprez PY

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-based regimens may be beneficial, particularly for patients with wild-type (WT) KRAS. CASE PRESENTAT...

journal_title：BMC cancer

authors： Ma J,Yang QL,Ling Y

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding the molecular biology and progression of cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its...

journal_title：BMC cancer

authors： Liu XH,Liu ZL,Sun M,Liu J,Wang ZX,De W

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the mechanisms underlying chemotherapy resistance and tumour progression in patient...

journal_title：BMC cancer

authors： Lapin M,Tjensvoll K,Oltedal S,Javle M,Smaaland R,Gilje B,Nordgård O

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS:The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were...

journal_title：BMC cancer

authors： Stücker I,Loriot MA,N'koutchou G,Cénée S,Bodin L,Mulot C,Gelu-Simeon M,Pelletier L,Bronowicki JP,Degos F,Beaune P,Laurent-Puig P,Hémon D,Trinchet JC,Pelletier G

更新日期：2007-11-19 00:00:00

abstract：BACKGROUND:Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody used in association with chemotherapy in met...

journal_title：BMC cancer

authors： Lereclus E,Tout M,Girault A,Baroukh N,Caulet M,Borg C,Bouché O,Ternant D,Paintaud G,Lecomte T,Raoul W

更新日期：2017-03-27 00:00:00

abstract：BACKGROUND:Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism is not fully elucidate...

journal_title：BMC cancer

authors： Sato Y,Kubo T,Morimoto K,Yanagihara K,Seyama T

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone metastasis was investigated in a cohort of patients. We have tried to draw the criteria to use adjuvant bisphosphonate. METHODS:Consecutive breast cancer patients undergoing surgery between 19...

journal_title：BMC cancer

authors： Koizumi M,Yoshimoto M,Kasumi F,Iwase T

更新日期：2010-07-21 00:00:00

abstract：CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Wang X,Chen J,Wang J,Yu F,Zhao S,Zhang Y,Tang H,Peng Z

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are ...

journal_title：BMC cancer

authors： Hughes B,Yip D,Goldstein D,Waring P,Beshay V,Chong G

更新日期：2004-10-09 00:00:00

abstract：BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...

journal_title：BMC cancer

authors： Havre PA,Dang LH,Ohnuma K,Iwata S,Morimoto C,Dang NH

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether...

journal_title：BMC cancer

authors： Borch KB,Braaten T,Lund E,Weiderpass E

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Pneumatosis cystoides intestinalis (PCI) is a rare self-limiting condition characterized by air-filled cysts within intestinal walls. Diagnosis should be prudent because it can mimic pneumoperitoneum leading to unnecessary treatment such as surgical exploration. Although various drugs including anti-neoplast...

journal_title：BMC cancer

authors： Lee YS,Han JJ,Kim SY,Maeng CH

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:About 5-10% of breast cancer is due to inherited disease predisposition. Many previously identified susceptibility factors are involved in the maintenance of genomic integrity. AATF plays an important role in the regulation of gene transcription and cell proliferation. It induces apoptosis by associating wit...

journal_title：BMC cancer

authors： Haanpää M,Reiman M,Nikkilä J,Erkko H,Pylkäs K,Winqvist R

更新日期：2009-12-21 00:00:00

abstract：BACKGROUND:We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival (OS) in an expanded access cohort of trastuzumab-treated HER2-positive patients with metastatic brea...

journal_title：BMC cancer

authors： Toi M,Sperinde J,Huang W,Saji S,Winslow J,Jin X,Tan Y,Ohno S,Nakamura S,Iwata H,Masuda N,Aogi K,Morita S,Petropoulos C,Bates M

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LBVI) including lymphatic (LVI) and blood (BVI) vessel invasion is a critical step in cancer metastasis. In breast cancer, the optimal detection method of LBVI remains unclear. This research aimed to compare the prognostic value of different assessments of the LVI and BVI in patients...

journal_title：BMC cancer

authors： Gujam FJ,Going JJ,Mohammed ZM,Orange C,Edwards J,McMillan DC

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:Cancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs for the 21 most prevalent cancer sites, and remaining tumour sites combined, in Ontario, Canada. M...

journal_title：BMC cancer

authors： de Oliveira C,Pataky R,Bremner KE,Rangrej J,Chan KK,Cheung WY,Hoch JS,Peacock S,Krahn MD

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lentivirus-mediated cytosine deaminase-thymidine kinase (CDglyTK) gene in transplanted breast cancer deli...

journal_title：BMC cancer

authors： Zhang J,Liu Y,Zang M,Zhu S,Chen B,Li S,Xue B,Yan L

更新日期：2019-09-14 00:00:00

abstract：BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in s...

journal_title：BMC cancer

authors： Patel T

更新日期：2002-05-03 00:00:00