Abstract:
BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies. METHODS:Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates. RESULTS:An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 +/- 1.5, and for females was 5.1 +/- 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 +/- 0.4 for males, but -1.3 +/- 0.4 for females. CONCLUSIONS:There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Patel Tdoi
10.1186/1471-2407-2-10keywords:
subject
Has Abstractpub_date
2002-05-03 00:00:00pages
10issn
1471-2407journal_volume
2pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:The aim of this study was to determine whether radiation (RT)-induced inflammatory responses and organ damage might be modulated by androgen deprivation therapies. METHODS:The mRNA and tissue sections obtained from the lungs, intestines and livers of irradiated mice with or without androgen deprivation were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-92
更新日期:2009-03-25 00:00:00
abstract:BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2869-x
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers. METHODS:PubMed, Web of Science, EMBASE a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4073-7
更新日期:2018-03-07 00:00:00
abstract:BACKGROUND:Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for the treatment of advanced UC after failure of platinum-based chemotherapy. However, to our knowledge...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2666-6
更新日期:2016-08-12 00:00:00
abstract:BACKGROUND:Smoking is by far the most important cause of cancer that can be modified at the individual level. Cancer incidence and mortality rates in Korea are the highest among all Asian countries, and smoking prevalence in Korean men is one of the highest in developed countries. The purpose of the current study was t...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-406
更新日期:2014-06-06 00:00:00
abstract:BACKGROUND:Salivary gland cancer (SGC) is one of the common malignancies of the head and neck area. It develops in the minor and major salivary glands and sometimes metastasizes to other organs, particularly to the lungs. Inhibitors of differentiation (Id) proteins are negative regulators of basic helix-loop-helix tran...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-141
更新日期:2013-03-22 00:00:00
abstract:BACKGROUND:FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis. Consistent with its role in proliferation, elevated expression of FOXM1 has been reported in a variety of human tumour entities. FOXM1 is a gene of interest because recently chemical in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-42
更新日期:2008-02-06 00:00:00
abstract:BACKGROUD:The incidence of recurrent laryngeal nerve (RLN) injury has increased due to RLN lymph node dissection. The aim of this study was to evaluate the ability of intraoperative ultrasonography (IU) to detect RLN nodal metastases in esophageal cancer patients. METHODS:Sixty patients with esophageal cancer underwen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4643-8
更新日期:2018-07-13 00:00:00
abstract:BACKGROUND:Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-negative metastatic breast cancer who had received prior chemotherapy for their metastatic disease. MET...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-14-820
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:pressurized intraperitoneal aerosol chemotherapy (PIPAC), with or without electrostatic precipitation (ePIPAC), was recently introduced in the treatment of peritoneal metastases (PM) from ovarian cancer (OC). Preliminary clinical data are promising, but several methodological issues as well the anticancer ef...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5658-5
更新日期:2019-05-07 00:00:00
abstract:BACKGROUND:Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. CASE PRESENTATION:We describe a pat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-94
更新日期:2005-08-04 00:00:00
abstract:BACKGROUND:Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cancer (PCa) aggressivenes...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-672
更新日期:2010-12-06 00:00:00
abstract:BACKGROUND:Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-218
更新日期:2012-06-06 00:00:00
abstract:BACKGROUND:There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For metastatic prostate cancer (PCa), the bone marrow microenvironment influences metastasis, drug response, and possibly drug resistance. METHODS:Using a nov...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4473-8
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the mechanism of caspase-9 inhibition, with a focus on a possible rol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-166
更新日期:2006-06-23 00:00:00
abstract:BACKGROUND:Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2. METHODS:ATC were generated from PBMC activated for 14 days with anti-CD3 monoclonal antibody in th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-83
更新日期:2013-02-22 00:00:00
abstract:BACKGROUND:Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15, UGT2B17, and UGT2B28 enzymes has not been evaluated in prostate...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3463-6
更新日期:2017-07-03 00:00:00
abstract:BACKGROUND:DEK is a transcription factor involved in stabilization of heterochromatin and cruciform structures. It plays an important role in development and progression of different types of cancer. This study aims to analyze the role of DEK in metastatic colorectal cancer. METHODS:Baseline DEK expression was firstly...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-965
更新日期:2014-12-16 00:00:00
abstract:BACKGROUND:The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic significance in patients with breast cancer. METHODS:PubMed,...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-015-1742-7
更新日期:2015-10-17 00:00:00
abstract:BACKGROUND:Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress for cancer patients. However, objective assessment by medical staff makes it easy to underestimate ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6113-3
更新日期:2019-09-10 00:00:00
abstract:BACKGROUND:The scientific and public debate concerning organized mammography screening is unprecedentedly strong. With research evidence concerning its efficacy being ambiguous, the recommendations pertaining to the age-thresholds for program inclusion vary between - and even within - countries. Data shows that young w...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3180-1
更新日期:2017-03-21 00:00:00
abstract:BACKGROUND:This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC. METHODS:We employed 2 human ESCC cell lines, Eca109 and TE-1, as the model system. The effect of miR-203 and ΔNp63 on cell proliferati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-57
更新日期:2011-02-07 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR mutations and are generally refractory to the 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs). Development of effective therapies for patients with EGFRex20ins mutant non-small-cell ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5820-0
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Febrile neutropenia (FN) is common in breast cancer patients undergoing chemotherapy. Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This study aimed to evaluate the predictive value of patient-related, chemotherapy-related, and genetic risk...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-201
更新日期:2014-03-19 00:00:00
abstract:BACKGROUND:Significant progress in treatment of metastatic castration resistant prostate cancer (mCRPC) has been made. Biomarkers to tailor therapy are scarce. To facilitate decision-making we evaluated dynamic changes of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and prostate specific antigen (PSA) under ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2260-y
更新日期:2016-03-14 00:00:00
abstract:BACKGROUND:In this retrospective study, the authors evaluated the prognostic value of whole-body total lesion glycolysis (WTLG) on FDG/PET images in metastatic breast cancer (MBC) patients. METHODS:We retrospectively evaluated 54 MBC patients who were diagnosed as having one or more metastatic lesions between June 200...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-525
更新日期:2014-07-21 00:00:00
abstract:BACKGROUND:The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant cells is still controversial, and the cell subsets and the mechanisms involved are poorly investiga...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-256
更新日期:2010-06-04 00:00:00
abstract:BACKGROUND:Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increase...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-138
更新日期:2013-03-21 00:00:00
abstract:BACKGROUND:In developed countries, the lifetime risk of developing colorectal cancer (CRC) is 5%, and it is the second leading cause of death from cancer. The presence of family history is a well established risk factor with 25-35% of CRCs attributable to inherited and/or familial factors. The highly penetrant inherite...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-424
更新日期:2011-10-04 00:00:00
abstract:BACKGROUND:The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multiple tyrosine kinase o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1131-2
更新日期:2015-03-08 00:00:00