Worldwide trends in mortality from biliary tract malignancies.


BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies. METHODS:Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates. RESULTS:An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 +/- 1.5, and for females was 5.1 +/- 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 +/- 0.4 for males, but -1.3 +/- 0.4 for females. CONCLUSIONS:There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.


BMC Cancer


BMC cancer


Patel T





Has Abstract


2002-05-03 00:00:00








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    abstract:BACKGROUND:Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked ...

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    authors: Song Q,Yi F,Zhang Y,Jun Li DK,Wei Y,Yu H,Zhang Y

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    abstract:BACKGROUND:Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathway in chondrosarcoma to determine if it can be a target for therapy, which was therefore explored in ...

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    authors: Peterse EF,Cleven AH,De Jong Y,Briaire-de Bruijn I,Fletcher JA,Danen EH,Cleton-Jansen AM,Bovée JV

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    authors: Schäfer S,Weibel S,Donat U,Zhang Q,Aguilar RJ,Chen NG,Szalay AA

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  • Metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component causing diagnostic challenges.

    abstract:BACKGROUND:Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component. CASE PRESENTATION:A 47-year-old woman presented with left breas...

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    abstract:BACKGROUND:Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. METHODS:To compare the functional role of E-cadherin and P-cadherin in inva...

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    pub_type: 杂志文章


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