Abstract:
BACKGROUND:Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers. In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and correlated this with several clinico-pathological and prognostic factors. METHODS:SOCS1-7 mRNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples (n = 127) and normal background breast tissue (n = 31). Transcript levels of expression were determined using real-time PCR and analyzed against TNM stage, tumour grade and clinical outcome over a 10 year follow-up period. RESULTS:SOCS1,4,5,6 and 7 expression decreased with increased TNM stage (TNM1 vs. TNM3 p = 0.039, TNM1 vs. TNM4 p = 0.016, TNM2 vs. TNM4 p = 0.025, TNM1 vs. TNM3 p = 0.012, and TNM1 vs. TNM3 p = 0.044 respectively). SOCS2 and 3 expression decreased with increased Nottingham Prognostic Index (NPI) (NPI1 vs. NPI3 p = 0.033, and NPI2 vs. NPI3 p = 0.041 respectively). SOCS7 expression decreased with higher tumour grade (Grade 3 vs. Grade 2 p = 0.037). After a median follow up period of 10 years, we found higher levels of SOCS1,2 and 7 expression among those patients who remained disease-free compared to those who developed local recurrence (p = 0.0073, p = 0.021, and p = 0.039 respectively). Similarly, we found higher levels of SOCS 2,4, and 7 expression in those who remained disease-free compared to those who developed distant recurrence (p = 0.022, p = 0.024, and p = 0.033 respectively). Patients who remained disease-free had higher levels of SOCS1 and 2 expression compared to those who died from breast cancer (p = 0.02 and p = 0.033 respectively). The disease free survival (DFS) and overall survival (OS) curves showed that higher levels of SOCS1, 3 and 7 were significant predictors of higher DFS (p = 0.015, p = 0.024 and 0.03 respectively) and OS (p = 0.005, p = 0.013 and p = 0.035 respectively). Higher levels of SOCS 4 were significant in predicting better OS (p = 0.007) but not DFS. Immunohistochemical staining of representative samples showed a correlation between SOCS1, 3, 7 protein staining and the SOCS1, 3, 7 mRNA expression. CONCLUSION:Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Sasi W,Jiang WG,Sharma A,Mokbel Kdoi
10.1186/1471-2407-10-178subject
Has Abstractpub_date
2010-04-30 00:00:00pages
178issn
1471-2407pii
1471-2407-10-178journal_volume
10pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Mucosal melanomas represent about 1% of all melanoma cases and classically have a worse prognosis than cutaneous melanomas. Due to the rarity of mucosal melanomas, only limited clinical studies with metastatic mucosal melanoma are available. Mucosal melanomas most commonly contain mutations in the gene CKIT,...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-516
更新日期:2014-07-16 00:00:00
abstract:BACKGROUND:Solitary plasmacytoma (SP) is a localized neoplastic plasma cell disorder with an annual incidence of less than 450 cases. Given the rarity of this disorder, it is difficult to conduct large-scale population studies. Consequently, very limited information on the disorder is available, making it difficult to ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3015-5
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway inhibitory genes are silenced by CpG hypermethylation, and other studies have suggested that genistein...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-145
更新日期:2012-04-11 00:00:00
abstract:BACKGROUND:Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluated a well-established hepatic tumor cell line, HepG2, and an adul...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-402
更新日期:2012-09-10 00:00:00
abstract:BACKGROUND:Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. METHODS:We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-14-391
更新日期:2014-06-02 00:00:00
abstract:BACKGROUND:The survival following transarterial chemoembolization (TACE) alone is still low in unresectable hepatocellular carcinoma (HCC) with almost patients developing disease progression after treatment. There is need to investigate additional therapeutic options that would intensify the initial response to TACE. T...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2894-9
更新日期:2016-11-03 00:00:00
abstract:BACKGROUND:Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma (PMBCL). However, their CNA-based profile and clinical impact still remain unc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07293-3
更新日期:2020-08-27 00:00:00
abstract:BACKGROUND:Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, including CAPRA-S, are currently used for disease prognostication. However, high...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07438-4
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:A universal hallmark of cancer cells is the change in their glycosylation phenotype. One of the most frequent alterations in the normal glycosylation pattern observed during carcinogenesis is the enhancement of α(1,6)linked fucose residues of glycoproteins, due to the up-regulation of the α(1,6)fucosyltransf...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-508
更新日期:2011-12-07 00:00:00
abstract:BACKGROUND:As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of cancer-related pain in the outpatient setting. METHODS:We conducted a prospective study to compare rein...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07270-w
更新日期:2020-09-04 00:00:00
abstract:BACKGROUND:The purpose of this case report is to describe a conjunctiva and eyelid Kaposi's sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection. CAS...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4611-3
更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lentivirus-mediated cytosine deaminase-thymidine kinase (CDglyTK) gene in transplanted breast cancer deli...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6111-5
更新日期:2019-09-14 00:00:00
abstract:BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07081-z
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-282
更新日期:2013-06-11 00:00:00
abstract:BACKGROUND:Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib is used for mRCC chemotherapy based on the favorable results of a recent clinical trial, but specifi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1443-2
更新日期:2015-05-22 00:00:00
abstract:BACKGROUND:The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS:In a candid...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-181
更新日期:2009-06-12 00:00:00
abstract:BACKGROUND:Extramural tumor deposits (TDs) and extracapsular lymph node involvement (ECLNI) are considered to be poor prognostic factors in patients with T3-4, N0-2, M0 colorectal cancer (CRC). Although TDs are known to have multiple origins and pleomorphic features, the prognostic significances of the different type o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1885-6
更新日期:2015-11-06 00:00:00
abstract:BACKGROUND:It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. METHODS:The methods of im...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-133
更新日期:2010-04-08 00:00:00
abstract:BACKGROUND:Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia are presented using nation-wide data from two population-based cancer registries. These rates are a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-18
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The purpose of this study was to investigate the prognostic factors for disease-specific survival at the in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07384-1
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. METHOD:Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6203-2
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:We describe a patient who underwent transurethral resection of the prostate for urinary obstructive symptoms and had histological findings of adenocarcinoma of the prostate with prostatic localization of chronic lymphocitic leukemia (CLL). The contemporary presence of CLL, adenocarcinoma of the prostate and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-95
更新日期:2004-12-22 00:00:00
abstract:BACKGROUND:Less than 1% of all breast cancer cases are found in men, who reportedly have inferior outcomes compared with matched women patients. Ethnic differences may also affect their prognosis. Here, we investigated overall survival (OS) and major prognostic factors for male breast cancer (MBC) in a cohort of Egypti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-227
更新日期:2014-03-28 00:00:00
abstract:BACKGROUND:Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer tre...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3806-3
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds of breast cancer, without tumor-specific treatment options and accounts for 15% of all types of breast ca...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-120
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:A candidate oncogene GIG47, previously known as a neudesin with a neurotrophic activity, was identified by applying the differential expression analysis method. METHODS:As a first step to understand the molecular role of GIG47, we analyzed the expression profile of GIG47 in multiple human cancers including ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-274
更新日期:2012-07-02 00:00:00
abstract:BACKGROUND:Colon cancer patients with the same stage show diverse clinical behavior due to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray expression patterns, to analyze whether the molecular classification correlated with the histopathological stages or other clinical paramete...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-260
更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-164
更新日期:2006-06-23 00:00:00
abstract:BACKGROUND:Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS:All patients diagnosed with CRC be...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-339
更新日期:2009-09-24 00:00:00
abstract:BACKGROUND:Oncolytic viruses, including vaccinia virus (VACV), are a promising alternative to classical mono-cancer treatment methods such as surgery, chemo- or radiotherapy. However, combined therapeutic modalities may be more effective than mono-therapies. In this study, we enhanced the effectiveness of oncolytic vir...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-366
更新日期:2012-08-23 00:00:00