Prognostic significance of classified extramural tumor deposits and extracapsular lymph node invasion in T3-4 colorectal cancer: a retrospective single-center study.

abstract：BACKGROUND:Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua),...

journal_title：BMC cancer

authors： Nyaga SG,Lohani A,Jaruga P,Trzeciak AR,Dizdaroglu M,Evans MK

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...

journal_title：BMC cancer

authors： Oberste M,Schaffrath N,Schmidt K,Bloch W,Jäger E,Steindorf K,Hartig P,Joisten N,Zimmer P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:The principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is sti...

journal_title：BMC cancer

authors： Suh HY,Choi H,Paeng JC,Cheon GJ,Chung JK,Kang KW

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the incidence and prognostic value of disseminated tumor cells in bone marrow of breast carcinoma patients with early disease, and to analyze this finding in relation to lymph node involvement, determined by sentinel lymph node (SLN) biopsy analysis, and to prognostic...

journal_title：BMC cancer

authors： Solá M,Margelí M,Castellá E,Julian JF,Rull M,Gubern JM,Mariscal A,Barnadas A,Fraile M

更新日期：2011-06-16 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ova...

journal_title：BMC cancer

authors： Serce NB,Boesl A,Klaman I,von Serényi S,Noetzel E,Press MF,Dimmler A,Hartmann A,Sehouli J,Knuechel R,Beckmann MW,Fasching PA,Dahl E

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:Brain metastases (BM) represent one of the most frequent complications related to cancer, and their treatment continues to evolve. We have evaluated the activity, toxicity and the impact on Quality of Life (QoL) of a concomitant treatment with whole brain radiotherapy (WBRT) and Temozolomide (TMZ) in patient...

journal_title：BMC cancer

authors： Addeo R,Caraglia M,Faiola V,Capasso E,Vincenzi B,Montella L,Guarrasi R,Caserta L,Del Prete S

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:Albendazole (ABZ) is a microtubule-targeting anthelmintic with a remarkable activity against a variety of human cancer cells. In this study, we examined if the antitumor activity of ABZ could be enhanced by its combination with other microtubule-binding agents. METHODS:The interactions between ABZ and micro...

journal_title：BMC cancer

authors： Ehteda A,Galettis P,Pillai K,Morris DL

更新日期：2013-02-23 00:00:00

abstract：BACKGROUND:Despite introduction of effective chemotherapy protocols, it has remained uncertain, if patients with colorectal cancer (CRC) liver metastases should receive adjuvant therapy. Clinical or molecular predictors may help to select patients at high risk for disease recurrence and death who obtain a survival adva...

journal_title：BMC cancer

authors： Rahbari NN,Reissfelder C,Schulze-Bergkamen H,Jäger D,Büchler MW,Weitz J,Koch M

更新日期：2014-03-11 00:00:00

abstract：BACKGROUND:Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms f...

journal_title：BMC cancer

authors： Blank S,Rachakonda S,Keller G,Weichert W,Lordick F,Langer R,Springfeld C,Bruckner T,Becker K,Kumar R,Ott K

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome that is commonly associated with a germline mutation in the tumor suppressor gene p53. Loss of p53 results in increased expression of CD44, a cancer stem cell (CSC) marker, which is involved in the scavenging of reactive oxygen species...

journal_title：BMC cancer

authors： Yoshida GJ,Fuchimoto Y,Osumi T,Shimada H,Hosaka S,Morioka H,Mukai M,Masugi Y,Sakamoto M,Kuroda T

更新日期：2012-10-02 00:00:00

abstract：BACKGROUND:Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma. METHODS:Here we investigated genomic aberrations affecting genes of the intrinsic apop...

journal_title：BMC cancer

authors： Lamers F,Schild L,Koster J,Speleman F,Øra I,Westerhout EM,van Sluis P,Versteeg R,Caron HN,Molenaar JJ

更新日期：2012-07-12 00:00:00

abstract：BACKGROUND:To validate the robust predictive values of tumor vascularity and hand-foot-skin reaction (HFSR) in combination treatment of transarterial chemoembolization (TACE) and sorafenib for patients with intermediate hepatocellular carcinoma (HCC), and then select the potential candidates who would survive best from...

journal_title：BMC cancer

authors： Wang E,Xia D,Bai W,Yuan J,Li X,Niu J,Yin Z,Xia J,Cai H,Fan D,Han G,Liu L

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academic-clinical practice three-year project to increase breast cancer screening among young breast cancer survivor...

journal_title：BMC cancer

authors： Katapodi MC,Northouse LL,Schafenacker AM,Duquette D,Duffy SA,Ronis DL,Anderson B,Janz NK,McLosky J,Milliron KJ,Merajver SD,Duong LM,Copeland G

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC). METHODS:The specimens of NSCLC from 305 Chinese patients with follow-up were analyzed for CD133 protein expression and VM by immunohistochemical and histoche...

journal_title：BMC cancer

authors： Wu S,Yu L,Wang D,Zhou L,Cheng Z,Chai D,Ma L,Tao Y

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death and upregulation of 78-kDa glucose-regulated protein (GRP78). We hypothesized that chemotherapy induc...

journal_title：BMC cancer

authors： Raiter A,Lipovetzki J,Lubin I,Yerushalmi R

更新日期：2020-04-19 00:00:00

abstract：BACKGROUNDS:Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed promising results for gastric cancers. However, the influence of preoperative adverse events (AEs) on postoperative complications remains unknown. The aim of this study was to identify correlations between them. METHODS:Clinical data and l...

journal_title：BMC cancer

authors： Li SX,Seo SH,Choi YY,Nakagawa M,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms responsible for ES metastasis remain poorly understood. In this study, we aimed to explore whether Wn...

journal_title：BMC cancer

authors： Jin Z,Zhao C,Han X,Han Y

更新日期：2012-10-18 00:00:00

abstract：BACKGROUND:The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative effect of common risk variants in DNA (polygenic risk). Assessing a woman's breast cancer risk by testi...

journal_title：BMC cancer

authors： Yanes T,Meiser B,Young MA,Kaur R,Mitchell G,Barlow-Stewart K,Roscioli T,Halliday J,James P

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association between pre-operative plasma metabolites and risk of biochemical-, local- and metastatic-recurrence,...

journal_title：BMC cancer

authors： Zoni E,Minoli M,Bovet C,Wehrhan A,Piscuoglio S,Ng CKY,Gray PC,Spahn M,Thalmann GN,Kruithof-de Julio M

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported ...

journal_title：BMC cancer

authors： Shang L,Fang Z,Liu J,Du F,Jing H,Xu Y,Dong K,Zhang X,Wu H,Jing C,Li L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations. METHODS:Subjects with biopsy confirmed untreated lung cancer, and others at risk for developing lung cancer, provided a urine sample. A colorimetric sens...

journal_title：BMC cancer

authors： Mazzone PJ,Wang XF,Lim S,Choi H,Jett J,Vachani A,Zhang Q,Beukemann M,Seeley M,Martino R,Rhodes P

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Pneumatosis cystoides intestinalis (PCI) is a rare self-limiting condition characterized by air-filled cysts within intestinal walls. Diagnosis should be prudent because it can mimic pneumoperitoneum leading to unnecessary treatment such as surgical exploration. Although various drugs including anti-neoplast...

journal_title：BMC cancer

authors： Lee YS,Han JJ,Kim SY,Maeng CH

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:Muscle invasive bladder cancer (MIBC) is often lethal and non-MIBC (NMIBC) can recur and progress, yet prognostic markers are currently inadequate. SAM68, a member of RNA-binding proteins, has been reported to contribute to progression of other cancers. The aim of this study is to investigate the potential u...

journal_title：BMC cancer

authors： Zhang Z,Yu C,Li Y,Jiang L,Zhou F

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:In China, there are currently no approved therapies for the treatment of metastatic renal cell carcinoma (mRCC) following progression with vascular endothelial growth factor (VEGF)-targeted agents. In the phase 3 RECORD-1 trial, the mammalian target of rapamycin (mTOR) inhibitor everolimus afforded clinical ...

journal_title：BMC cancer

authors： Guo J,Huang Y,Zhang X,Zhou F,Sun Y,Qin S,Ye Z,Wang H,Jappe A,Straub P,Pirotta N,Gogov S

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling. METHODS:To test the importance of TGFβ signaling to...

journal_title：BMC cancer

authors： Simms NA,Rajput A,Sharratt EA,Ongchin M,Teggart CA,Wang J,Brattain MG

更新日期：2012-06-06 00:00:00

abstract：BACKGROUND:Breast metastasis from lung cancer has been reported, but not from SCLC that is transformed from lung adenocarcinoma during maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Transformation to small cell lung cancer(SCLC), although uncommonly seen, has been asso...

journal_title：BMC cancer

authors： Lin Q,Cai GP,Yang KY,Yang L,Chen CS,Li YP

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need for repeat surgery. This individual patient data (IPD) meta-analysis examines MRI's agreement with pa...

journal_title：BMC cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,Mamounas E,von Minckwitz G,Guarneri V,Partridge SC,Wright FC,Choi JH,Bhattacharyya M,Martincich L,Yeh E,Londero V,Houssami N

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...

journal_title：BMC cancer

authors： Inari H,Teruya N,Kishi M,Horii R,Akiyama F,Takahashi S,Ito Y,Ueno T,Iwase T,Ohno S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Most staging systems for soft tissue sarcoma are based on histologic malignancy-grade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth per se should influence a tumor's metastatic capability. Therefore we hypothesized that the unf...

journal_title：BMC cancer

authors： Rydholm A,Gustafson P

更新日期：2003-05-26 00:00:00

abstract：BACKGROUND:The purpose of our study was to investigate the immunohistochemical expression of TGF-beta1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We also aimed to evaluate the expression of TGF-beta1 and p27 in the context of other cell cycle an...

journal_title：BMC cancer

authors： Culhaci N,Sagol O,Karademir S,Astarcioglu H,Astarcioglu I,Soyturk M,Oztop I,Obuz F

更新日期：2005-08-08 00:00:00