Abstract:
BACKGROUND:Despite introduction of effective chemotherapy protocols, it has remained uncertain, if patients with colorectal cancer (CRC) liver metastases should receive adjuvant therapy. Clinical or molecular predictors may help to select patients at high risk for disease recurrence and death who obtain a survival advantage by adjuvant chemotherapy. METHODS:A total of 297 patients with potentially curative resection of CRC liver metastases were analyzed. These patients had no neoadjuvant therapy, no extrahepatic disease and negative resection margins. The primary endpoint was overall survival. Patients' risk status was evaluated using the Memorial Sloan-Kettering Cancer Center clinical risk score (MSKCC-CRS). Multivariable analyses were performed using Cox proportional hazard models. RESULTS:A total of 137 (43%) patients had a MSKCC-CRS > 2. Adjuvant chemotherapy was administered to 116 (37%) patients. Patients who received adjuvant chemotherapy were of younger age (p = 0.03) with no significant difference in the presence of multiple metastases (p = 0.72) or bilobar metastases (p = 0.08). On multivariate analysis adjuvant chemotherapy was associated with improved survival in the entire cohort (Hazard ratio 0.69; 95% confidence interval 0.69-0.98). It improved survival markedly in high-risk patients with a MSKCC-CRS > 2 (HR 0.40; 95% CI 0.23-0.69), whereas it was of no benefit in patients with a MSKCC-CRS ≤ 2 (HR 0.90; 95% CI 0.57-1.43). CONCLUSIONS:The MSKCC-CRS offers a tool to select patients for adjuvant therapy after resection of CRC liver metastases. Validation in independent patient cohorts is required.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Rahbari NN,Reissfelder C,Schulze-Bergkamen H,Jäger D,Büchler MW,Weitz J,Koch Mdoi
10.1186/1471-2407-14-174subject
Has Abstractpub_date
2014-03-11 00:00:00pages
174issn
1471-2407pii
1471-2407-14-174journal_volume
14pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms responsible for ES metastasis remain poorly understood. In this study, we aimed to explore whether Wn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-480
更新日期:2012-10-18 00:00:00
abstract:BACKGROUND:We report an extremely rare case of vaginal clear cell carcinoma, which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol (DES) exposure. CASE PRESENTATION:In this case, the patient was a Chinese woman with a history of two decades of intermittent vaginal p...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-6026-1
更新日期:2019-08-13 00:00:00
abstract:BACKGROUND:Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2094-7
更新日期:2016-02-04 00:00:00
abstract:BACKGROUND:The Nijmegen Breakage Syndrome is a chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency, and increased frequency of cancers. Familial studies on relatives of these patients indicated that they also appear to be at increased risk of cancer. METHODS:In a candid...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-181
更新日期:2009-06-12 00:00:00
abstract:BACKGROUND:When individuals stop working due to cancer this represents a loss to society - the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from all adult cancers and from the 20 highest mortality adult cancers in Ireland in 2011, and project the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2854-4
更新日期:2016-10-18 00:00:00
abstract:BACKGROUND:5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good performance status. We investigated this combination as neoadjuvant therapy for locally advanced pancreatic cancer (LAPC). METHODS:In this retrospectiv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-199
更新日期:2012-05-29 00:00:00
abstract:BACKGROUND:Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. METHODS:We conducted a nested case-control study of ASA use after a breast cancer diagnosis among women using Swedish National Registries. We assessed prospectively recorded ASA exposure during several...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-14-391
更新日期:2014-06-02 00:00:00
abstract:BACKGROUND:Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2089-4
更新日期:2016-02-18 00:00:00
abstract:BACKGROUND:Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway inhibitory genes are silenced by CpG hypermethylation, and other studies have suggested that genistein...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-145
更新日期:2012-04-11 00:00:00
abstract:BACKGROUND:Stimulation of vascular endothelial growth factor (VEGF) has been observed following transarterial chemoembolization (TACE) in hepatocellular cancer (HCC) and may contribute to tumor regrowth. This pilot study examined whether intravenous (IV) bevacizumab, a monoclonal antibody against VEGF, could inhibit ne...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-12-16
更新日期:2012-01-14 00:00:00
abstract:BACKGROUND:Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a contr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-350
更新日期:2010-07-02 00:00:00
abstract:BACKGROUND:This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). METHODS:A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4822-7
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-017-3371-9
更新日期:2017-06-02 00:00:00
abstract:BACKGROUND:The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. METHODS:Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-566
更新日期:2010-10-19 00:00:00
abstract:BACKGROUND:A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the research group, 80% of the patients with breast cancer reported a high level of stress symptoms close t...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-12-167
更新日期:2012-05-04 00:00:00
abstract:BACKGROUND:In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions in 109 cervical cancer patients. METHODS:We used immunohistochemistry of formalin-fixed, paraffin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-256
更新日期:2006-10-26 00:00:00
abstract:BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial r...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-95
更新日期:2006-04-18 00:00:00
abstract:BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-662
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06987-y
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, particularly in health promotion and prevention. There are no randomized controlled trials in Latin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3870-8
更新日期:2017-12-13 00:00:00
abstract:BACKGROUND:Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for the treatment of advanced UC after failure of platinum-based chemotherapy. However, to our knowledge...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2666-6
更新日期:2016-08-12 00:00:00
abstract:BACKGROUND:Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS:The SHMT1 and MTHFR genotypes w...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-525
更新日期:2010-10-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC cancer
pub_type: 已发布勘误
doi:10.1186/s12885-020-07704-5
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Response-guided neoadjuvant chemotherapy (RG-NACT) with magnetic resonance imaging (MRI) is effective in treating oestrogen receptor positive/human epidermal growth factor receptor-2 negative (ER-positive/HER2-negative) breast cancer. We estimated the expected cost-effectiveness and resources required for it...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2653-y
更新日期:2016-09-05 00:00:00
abstract:BACKGROUND:Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing and analyzing data from large-scale projects, such as TCGA, is a demanding task. It is difficult to di...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5965-x
更新日期:2019-08-20 00:00:00
abstract:BACKGROUND:Total mesorectal excision is the standard surgical treatment for mid- and low-rectal cancer. Laparoscopy represents a clear leap forward in the management of rectal cancer patients, offering significant improvements in post-operative measures such as pain, first bowel movement, and hospital length of stay. H...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-017-3200-1
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. The RASSF1 locus contains two CpG islands (A and C) and generates seven transcripts (RASSF1A-RASSF1G) by differential promoter usage and alternative...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-351
更新日期:2011-08-12 00:00:00
abstract:BACKGROUND:Conditional survival (CS) measures the probability that patients will survive an additional number of years given that they have already survived for a certain period of time. METHODS:In total, 2935 gastric cancer patients who had undergone curative gastrectomy between 1995 and 2011 were enrolled. The Cox p...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2022-2
更新日期:2015-12-23 00:00:00
abstract:BACKGROUND:Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-19
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy. The anticipated consequence of all therapies is induction of tumor apoptosis. The highly resistance nature of PDACs to all therapies sugges...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4061-y
更新日期:2018-02-06 00:00:00