Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice.

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. METHOD:Women diagnosed with en...

journal_title：BMC cancer

authors： Li P,Shan B,Jia K,Hu F,Xiao Y,Zheng J,Gao YT,Wang H,Gao Y

更新日期：2020-06-20 00:00:00

abstract：BACKGROUND:The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5F...

journal_title：BMC cancer

authors： Rot S,Kaune T,Taubert H,Greither T,Kotrba J,Güttler A,Wichmann H,Bilkenroth U,Wienke A,Al-Nawas B,Bache M,Vordermark D,Wickenhauser C,Bethmann D,Eckert AW,Kappler M

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) usually presents in middle aged men and shows an indolent clinical behavior. However, up to 30% of the patients present a secondary transformation into aggressive diffuse large B cell lymphoma (DLBCL). The aim of the present study was to characterize mo...

journal_title：BMC cancer

authors： Hartmann S,Eray M,Döring C,Lehtinen T,Brunnberg U,Kujala P,Vornanen M,Hansmann ML

更新日期：2014-05-13 00:00:00

abstract：BACKGROUND:To investigate the incidence of gastrointestinal stromal tumors (GISTs) in Taiwan and the impact of imatinib on the overall survival (OS) of GIST patients. METHODS:GISTs were identified from the Taiwan Cancer Registry (TCR) from 1998 to 2008. The age-adjusted incidence rates and the observed OS rates were c...

journal_title：BMC cancer

authors： Chiang NJ,Chen LT,Tsai CR,Chang JS

更新日期：2014-02-18 00:00:00

abstract：BACKGROUND:Exercise has favorable effects on biomarkers associated with a lower risk of breast cancer, however it is unclear if higher doses of exercise provide additional effects. No clinical trial has systematically examined how different exercise volumes influence the mechanisms underlying breast cancer etiology. Th...

journal_title：BMC cancer

authors： Friedenreich CM,MacLaughlin S,Neilson HK,Stanczyk FZ,Yasui Y,Duha A,Lynch BM,Kallal C,Courneya KS

更新日期：2014-12-06 00:00:00

abstract：BACKGROUND:The apoptosis inhibitor-5 (API5), anti-apoptosis protein, is considered a key molecule in the tumor progression and malignant phenotype of tumor cells. Here, we investigated API5 expression in cervical cancer, its clinical significance, and its relationship with phosphorylated extracellular signal-regulated ...

journal_title：BMC cancer

authors： Cho H,Chung JY,Song KH,Noh KH,Kim BW,Chung EJ,Ylaya K,Kim JH,Kim TW,Hewitt SM,Kim JH

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Pro...

journal_title：BMC cancer

authors： Udeh EI,Ofoha CG,Adewole DA,Nnabugwu II

更新日期：2016-07-07 00:00:00

abstract：:... ...

journal_title：BMC cancer

authors： Knoerl R,Weller E,Halpenny B,Berry D

更新日期：2019-05-13 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need for repeat surgery. This individual patient data (IPD) meta-analysis examines MRI's agreement with pa...

journal_title：BMC cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,Mamounas E,von Minckwitz G,Guarneri V,Partridge SC,Wright FC,Choi JH,Bhattacharyya M,Martincich L,Yeh E,Londero V,Houssami N

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...

journal_title：BMC cancer

authors： Mikhitarian K,Martin RH,Ruppel MB,Gillanders WE,Hoda R,Schutte del H,Callahan K,Mitas M,Cole DJ

更新日期：2008-02-20 00:00:00

abstract：BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...

journal_title：BMC cancer

authors： Nakayama T,Ling ZQ,Mukaisho K,Hattori T,Sugihara H

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC. METHODS:We investigated SMAD4 status in PDAC by immunohistochemical methods to explore the relationshi...

journal_title：BMC cancer

authors： Wang Z,Li Y,Zhan S,Zhang L,Zhang S,Tang Q,Li M,Tan Z,Liu S,Xing X

更新日期：2019-11-04 00:00:00

abstract：BACKGROUND:Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs. CASE PRES...

journal_title：BMC cancer

authors： Abe M,Watanabe K,Shinozaki-Ushiku A,Ushiku T,Abe T,Fujihara Y,Amano Y,Zong L,Wang CP,Kubo E,Inaki R,Kinoshita N,Yamashita S,Takai D,Ushijima T,Nagase T,Hoshi K

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Cancer cell resistance to therapeutics can result from acquired or de novo-mediated factors. Here, we have utilised advanced breast cancer cell culture models to elucidate de novo doxorubicin resistance mechanisms. METHODS:The response of breast cancer cell lines (MCF-7 and MDA-MB-231) to doxorubicin was ex...

journal_title：BMC cancer

authors： Lovitt CJ,Shelper TB,Avery VM

更新日期：2018-01-06 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:To determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging in patients with breast lesions. METHODS:English and Chinese studies published prior to June 2009 to assess the diagnostic performance of quantitative DWI in patients with breast lesions were revi...

journal_title：BMC cancer

authors： Chen X,Li WL,Zhang YL,Wu Q,Guo YM,Bai ZL

更新日期：2010-12-29 00:00:00

abstract：:Fasting in disease prevention and treatment has recently become a popular topic, particularly in the context of oncology. Unfortunately, the growing attention paid by the media has created a background of speculations and ambiguous messages. The attitude towards the role of fasting in cancer patients should be very ca...

journal_title：BMC cancer

authors： Caccialanza R,Cereda E,De Lorenzo F,Farina G,Pedrazzoli P,AIOM-SINPE-FAVO Working Group.

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression of hepatocellular carcinoma. METHODS:In the present study, the e...

journal_title：BMC cancer

authors： An J,Zhang Z,Liu Z,Wang R,Hui D,Jin Y

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lentivirus-mediated cytosine deaminase-thymidine kinase (CDglyTK) gene in transplanted breast cancer deli...

journal_title：BMC cancer

authors： Zhang J,Liu Y,Zang M,Zhu S,Chen B,Li S,Xue B,Yan L

更新日期：2019-09-14 00:00:00

abstract：BACKGROUND:There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the abov...

journal_title：BMC cancer

authors： Zhao P,Chen Q,Lu W

更新日期：2017-11-09 00:00:00

abstract：BACKGROUND:The development and evaluation of new therapeutic approaches for malignant mesothelioma has been sparse due, in part, to lack of suitable tumor models. METHODS:We established primary mesothelioma cultures from pleural and ascitic fluids of five patients with advanced mesothelioma. Electron microscopy and im...

journal_title：BMC cancer

authors： Kalra N,Zhang J,Thomas A,Xi L,Cheung M,Talarchek J,Burkett S,Tsokos MG,Chen Y,Raffeld M,Miettinen M,Pastan I,Testa JR,Hassan R

更新日期：2015-05-08 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1alpha and STAT3 have been implicated in HCC progression, thus representing interesting targets for molecu...

journal_title：BMC cancer

authors： Moser C,Lang SA,Mori A,Hellerbrand C,Schlitt HJ,Geissler EK,Fogler WE,Stoeltzing O

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic th...

journal_title：BMC cancer

authors： Paiva TF Jr,de Jesus VH,Marques RA,da Costa AA,de Macedo MP,Peresi PM,Damascena A,Rossi BM,Begnami MD,de Lima VC

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a contr...

journal_title：BMC cancer

authors： Dorn J,Spatz H,Schmieder M,Barth TF,Blatz A,Henne-Bruns D,Knippschild U,Kramer K

更新日期：2010-07-02 00:00:00

abstract：BACKGROUND:Forkhead box P3(FOXP3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity. However, the research on the prognostic significance of tumor-infiltrating FOXP3+ Tregs in breast cancer is still limited and the ...

journal_title：BMC cancer

authors： Shou J,Zhang Z,Lai Y,Chen Z,Huang J

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (HCY), marker of folate metabolism was also investigated. METHODS:The SHMT1 and MTHFR genotypes w...

journal_title：BMC cancer

authors： Komlósi V,Hitre E,Pap E,Adleff V,Réti A,Székely E,Bíró A,Rudnai P,Schoket B,Müller J,Tóth B,Ottó S,Kásler M,Kralovánszky J,Budai B

更新日期：2010-10-04 00:00:00

abstract：BACKGROUND:We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment of metastatic colorectal cancer. METHODS:This trial was a randomized, two-armed, non-inferiority p...

journal_title：BMC cancer

authors： Kim ST,Hong YS,Lim HY,Lee J,Kim TW,Kim KP,Kim SY,Baek JY,Kim JH,Lee KW,Chung IJ,Cho SH,Lee KH,Shin SJ,Kang HJ,Shin DB,Lee JW,Jo SJ,Park YS

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Durvalumab is a standard drug used during maintenance therapy after chemoradiotherapy in patients with locally advanced non-small cell lung cancer (LA-NSCLC). However, little is known about the clinical benefits of durvalumab after chemoradiotherapy in patients with LA-NSCLC with a performance status (PS) of...

journal_title：BMC cancer

authors： Kaira K,Mouri A,Kato S,Yoshimura K,Kagamu H,Kobayashi K

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are crucially involved in the regulation of multiple stages of cancer progression. Elevated MMP levels have been associated with the development of metastases and poor prognosis in several types of cancer. However, the role of MMPs in osteosarcoma and their prognostic value i...

journal_title：BMC cancer

authors： Kunz P,Sähr H,Lehner B,Fischer C,Seebach E,Fellenberg J

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant type of stromal cell, in which TGF-β signaling is activated. Among the s...

journal_title：BMC cancer

authors： Horie M,Saito A,Noguchi S,Yamaguchi Y,Ohshima M,Morishita Y,Suzuki HI,Kohyama T,Nagase T

更新日期：2014-08-09 00:00:00