S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: updated results from a phase 3 trial.

abstract：BACKGROUND:The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K ...

journal_title：BMC cancer

authors： Krone B,Kölmel KF,Grange JM

更新日期：2014-08-16 00:00:00

abstract：BACKGROUND:Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers. In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and ...

journal_title：BMC cancer

authors： Sasi W,Jiang WG,Sharma A,Mokbel K

更新日期：2010-04-30 00:00:00

abstract：BACKGROUND:For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the preferred surgical approach worldwide. However, this procedure is associated with considerable morbidity. Several meta-analyses have shown an advantage in ...

journal_title：BMC cancer

authors： Haverkamp L,Brenkman HJ,Seesing MF,Gisbertz SS,van Berge Henegouwen MI,Luyer MD,Nieuwenhuijzen GA,Wijnhoven BP,van Lanschot JJ,de Steur WO,Hartgrink HH,Stoot JH,Hulsewé KW,Spillenaar Bilgen EJ,Rütter JE,Kouwenhoven EA,van

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening with mammography played a role in the decline in mortality. Evaluating the contribution of these int...

journal_title：BMC cancer

authors： Vilaprinyo E,Rué M,Marcos-Gragera R,Martínez-Alonso M

更新日期：2009-03-30 00:00:00

abstract：BACKGROUND:HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 overexpression, which facilitates the formation of cancer stem-like tumorspheres. However, the cellul...

journal_title：BMC cancer

authors： Chang YF,Lim KH,Chiang YW,Sie ZL,Chang J,Ho AS,Cheng CC

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:The epithelial cell adhesion molecule (EpCAM) has been shown to be overexpressed in breast cancer and stem cells and has emerged as an attractive target for immunotherapy of breast cancer patients. This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype. ...

journal_title：BMC cancer

authors： Martowicz A,Spizzo G,Gastl G,Untergasser G

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells...

journal_title：BMC cancer

authors： Quentmeier H,Eberth S,Romani J,Weich HA,Zaborski M,Drexler HG

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct molecular features compared to metastases of known origin. METHODS:Employing genome wide transcripto...

journal_title：BMC cancer

authors： Vikeså J,Møller AK,Kaczkowski B,Borup R,Winther O,Henao R,Krogh A,Perell K,Jensen F,Daugaard G,Nielsen FC

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a b...

journal_title：BMC cancer

authors： Stavik B,Skretting G,Aasheim HC,Tinholt M,Zernichow L,Sletten M,Sandset PM,Iversen N

更新日期：2011-08-17 00:00:00

abstract：BACKGROUND:Adjuvant endocrine therapy can improve disease-free survival and time before recurrence in breast cancer patients. However, it is associated with considerable side effects that negatively affect patients' quality of life and cause non-adherence. The recently demonstrated effect of individual expectations on ...

journal_title：BMC cancer

authors： von Blanckenburg P,Schuricht F,Albert US,Rief W,Nestoriuc Y

更新日期：2013-09-18 00:00:00

abstract：BACKGROUND:Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluate...

journal_title：BMC cancer

authors： Wu Y,Ye S,Goswami S,Pei X,Xiang L,Zhang X,Yang H

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, metastasis, and angioge...

journal_title：BMC cancer

authors： Chang AY,Wang M

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients. METHODS:In total, 90 participants including 60 PTC patients (15 males and 45 fe...

journal_title：BMC cancer

authors： Zarkesh M,Zadeh-Vakili A,Akbarzadeh M,Fanaei SA,Hedayati M,Azizi F

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major ro...

journal_title：BMC cancer

authors： Cegolon L,Salata C,Weiderpass E,Vineis P,Palù G,Mastrangelo G

更新日期：2013-01-03 00:00:00

abstract：BACKGROUND:To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use. METHODS:Pubmed and Embase were searched up the terms radiomics or radiogenomics and gliomas or glioblastomas until February 2019. From 189 articles, 51 ...

journal_title：BMC cancer

authors： Park JE,Kim HS,Kim D,Park SY,Kim JY,Cho SJ,Kim JH

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeasures against IBD-associated neoplasia are crucial. The purpose of this study is to develop a new dia...

journal_title：BMC cancer

authors： Kinugasa H,Hiraoka S,Nouso K,Yamamoto S,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Takahara M,Harada K,Tanaka T,Okada H

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression. The role of miRNAs in choriocarcinoma, however, is not well understood. In this study, we examined the effect of miR-3...

journal_title：BMC cancer

authors： Pang RT,Leung CO,Lee CL,Lam KK,Ye TM,Chiu PC,Yeung WS

更新日期：2013-01-18 00:00:00

abstract：BACKGROUND:This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. METHODS:We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohort) with c...

journal_title：BMC cancer

authors： Yang L,Wu Q,Xu L,Zhang W,Zhu Y,Liu H,Xu J,Gu J

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...

journal_title：BMC cancer

authors： Kelly-Morland C,Rudman S,Nathan P,Mallett S,Montana G,Cook G,Goh V

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker for lymphatic endothelium, provides powerful tools for studying tumor lymphangiogenesis. The purpose ...

journal_title：BMC cancer

authors： Zhang SQ,Yu H,Zhang LL

更新日期：2009-02-21 00:00:00

abstract：BACKGROUND:Brain metastases (BM) represent one of the most frequent complications related to cancer, and their treatment continues to evolve. We have evaluated the activity, toxicity and the impact on Quality of Life (QoL) of a concomitant treatment with whole brain radiotherapy (WBRT) and Temozolomide (TMZ) in patient...

journal_title：BMC cancer

authors： Addeo R,Caraglia M,Faiola V,Capasso E,Vincenzi B,Montella L,Guarrasi R,Caserta L,Del Prete S

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:Randomized controlled trials have established concurrent chemo-radiotherapy as the preferred treatment option for inoperable local-regionally advanced head and neck squamous cell carcinomas (HNSCCs). Because many patients have multiple co-morbidities and would not fulfill the eligibility criteria of clinical...

journal_title：BMC cancer

authors： Schlumpf M,Fischer C,Naehrig D,Rochlitz C,Buess M

更新日期：2013-12-27 00:00:00

abstract：BACKGROUND:The length of interval between successive childbirths (birth interval) might influence the incidence of breast cancer, either by stimulating or by inhibiting the factors that are responsible for the initiation of breast cancer or its early development. METHODS:This is a case-control study nested in a cohort...

journal_title：BMC cancer

authors： Katuwal S,Tapanainen JS,Pukkala E,Kauppila A

更新日期：2019-03-04 00:00:00

abstract：BACKGROUND:Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this moment, there are no specific treatment recommendations for patients with limited nodal recurrences a...

journal_title：BMC cancer

authors： De Bruycker A,Spiessens A,Dirix P,Koutsouvelis N,Semac I,Liefhooghe N,Gomez-Iturriaga A,Everaerts W,Otte F,Papachristofilou A,Scorsetti M,Shelan M,Siva S,Ameye F,Guckenberger M,Heikkilä R,Putora PM,Zapatero A,Conde-Mo

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, we evaluated the mechanism of cell death induced by ICRP in HeLa and MCF-7 cells. METHODS:Cell deat...

journal_title：BMC cancer

authors： Martínez-Torres AC,Reyes-Ruiz A,Calvillo-Rodriguez KM,Alvarez-Valadez KM,Uscanga-Palomeque AC,Tamez-Guerra RS,Rodríguez-Padilla C

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological v...

journal_title：BMC cancer

authors： Jia N,Cormack FC,Xie B,Shiue Z,Najafian B,Gralow JR

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is a plausible candidate. CHEK2 encodes a checkpoint...

journal_title：BMC cancer

authors： Rashid MU,Muhammad N,Faisal S,Amin A,Hamann U

更新日期：2013-06-27 00:00:00

abstract：BACKGROUND:Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In present study, we explored the mechanism of how TG2 may be involved in cell migration. METHODS:To study t...

journal_title：BMC cancer

authors： Kumar A,Hu J,LaVoie HA,Walsh KB,DiPette DJ,Singh US

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified. METHODS:One candidate is iron deficiency, as this is common in young women ...

journal_title：BMC cancer

authors： Jian J,Yang Q,Shao Y,Axelrod D,Smith J,Singh B,Krauter S,Chiriboga L,Yang Z,Li J,Huang X

更新日期：2013-06-24 00:00:00

abstract：:It has been highlighted that in the original manuscript [1] Table S3 'An example of the predictive computational modeling process. Specific details on an annexure section of the PD-L1 pathway show the step-by-step reactions, mechanisms, and reaction equations that occur. Such reactions also occurred in all of the othe...

journal_title：BMC cancer

authors： Brogden KA,Parashar D,Hallier AR,Braun T,Qian F,Rizvi NA,Bossler AD,Milhem MM,Chan TA,Abbasi T,Vali S

更新日期：2018-04-12 00:00:00