Abstract:
BACKGROUND:Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological variant, collapsing focal segmental glomerulosclerosis (CFSGS). CASE PRESENTATION:We describe a breast cancer patient who developed heavy proteinuria (protein/creatinine ratio 9.1) and nephrotic syndrome following treatment with oral ibandronate for 29 months. CFSGS was proven by biopsy. There was no improvement 1 month after ibandronate was discontinued. Prednisone and tacrolimus were started and she experienced a decreased in proteinuria. CONCLUSION:In patient who develops ibandronate-associated CFSGS, proteinuria appears to be at least partially reversible with the treatment of prednisone and/or tacrolimus if the syndrome is recognized early and ibandronate is stopped.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Jia N,Cormack FC,Xie B,Shiue Z,Najafian B,Gralow JRdoi
10.1186/s12885-015-1536-ysubject
Has Abstractpub_date
2015-07-22 00:00:00pages
535issn
1471-2407pii
10.1186/s12885-015-1536-yjournal_volume
15pub_type
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