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Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma.

Abstract：

BACKGROUND:Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this study was to evaluate the hemostatic status of nasopharyngeal carcinoma (NPC) patients by assessing plasma D-dimer levels to investigate its value as a prognostic marker. METHODS:We retrospectively analysed 717 patients with nasopharyngeal carcinoma, and we applied Cox regression and log-rank tests to assess the association of D-dimer levels with disease-free survival (DFS), distant metastasis-free survival (DMFS), and overall survival (OS). D-dimer levels were measured using a quantitative D-dimer latex agglutination assay. RESULTS:Using the 3rd quartile values (0.8 μg/L) as the optimal cut-offs, we found that patients with high D-dimer levels have a shorter 3-year DFS, (79%, 95%CI (73.1-84.9)) vs. (69%, 95%CI (59.2-78.8)), DMFS (87%, 95%CI (83.1-90.9)) vs. (77%, 95%CI (69.2-84.8)), and overall survival (82%, 95%CI (76.1-87.9)) vs. (76%, 95%CI (66.2-85.8)). Multivariate analysis revealed that pre-treatment D-dimer levels and EBV DNA were significant independent factors for DFS, DMFS, and OS in NPC patients. Subgroup analyses indicated that the plasma D-dimer levels could effectively stratify patient prognosis for early cancer, advanced stage cancer, and patients with EBV DNA ≥4000 copies/ml. CONCLUSIONS:High D-dimer levels were associated with poor disease-free survival, distant metastasis-free survival, overall survival, and increased risk of mortality in NPC patients. Prospective trials are required to assess the prognostic value of D-dimer levels.

journal_name

BMC Cancer

journal_title

BMC cancer

authors

Chen WH,Tang LQ,Wang FW,Li CP,Tian XP,Huang XX,Mai SJ,Liao YJ,Deng HX,Chen QY,Liu H,Zhang L,Guo SS,Liu LT,Yan SM,Li CF,Zhang JP,Liu Q,Liu XW,Liu LZ,Mai HQ,Zeng MS,Xie D

doi

10.1186/1471-2407-14-583

subject

Has Abstract

pub_date

2014-08-10 00:00:00

pages

583

issn

1471-2407

pii

1471-2407-14-583

journal_volume

14

pub_type

杂志文章

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