CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma.

abstract：BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...

journal_title：BMC cancer

authors： Park MH,Jo M,Won D,Song HS,Han SB,Song MJ,Hong JT

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Vinflunine is recommended in the European guideline for the treatment of advanced or metastatic urothelial cell carcinoma (UCC) after failure of platinum-based therapy. METHODS:This prospective, non-interventional study investigated the safety and efficacy of vinflunine in platinum-pretreated UCC patients i...

journal_title：BMC cancer

authors： Retz M,de Geeter P,Goebell PJ,Matz U,de Schultz W,Hegele A

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSCC and, although useful for predicting risk, manual assessment of histopathology is subjective and la...

journal_title：BMC cancer

authors： Bose P,Brockton NT,Guggisberg K,Nakoneshny SC,Kornaga E,Klimowicz AC,Tambasco M,Dort JC

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly focused on their gene expressions. The activation and function of the RTKs in ccRCC have not been full...

journal_title：BMC cancer

authors： Zhang Q,Liu JH,Liu JL,Qi CT,Yan L,Chen Y,Yu Q

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...

journal_title：BMC cancer

authors： Gomez-Millan J,Pajares B,Perez-Villa L,Carnero A,Alvarez M,De Luque V,Rivas F,Trigo JM,Toledo MD,Alba E,Medina JA

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients receiving palliative care. METHODS:A retrospective review of clinicopathological data from 378 cons...

journal_title：BMC cancer

authors： Zhao W,Wang P,Jia H,Chen M,Gu X,Liu M,Zhang Z,Cheng W,Wu Z

更新日期：2017-08-02 00:00:00

abstract：BACKGROUND:Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for the treatment of advanced UC after failure of platinum-based chemotherapy. However, to our knowledge...

journal_title：BMC cancer

authors： Bordi P,Tiseo M,Baldari G,Buti S

更新日期：2016-08-12 00:00:00

abstract：BACKGROUND:Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, little is known about the contribution of environmental tobacco smoke (ETS) to RCC incidence. This study...

journal_title：BMC cancer

authors： Theis RP,Dolwick Grieb SM,Burr D,Siddiqui T,Asal NR

更新日期：2008-12-24 00:00:00

abstract：BACKGROUND:Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic approaches is imperatively needed for this disease. We have recently shown that activation of AMP-acti...

journal_title：BMC cancer

authors： Yung MM,Chan DW,Liu VW,Yao KM,Ngan HY

更新日期：2013-07-03 00:00:00

abstract：BACKGROUND:The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblasto...

journal_title：BMC cancer

authors： Korja M,Jokilammi A,Salmi TT,Kalimo H,Pelliniemi TT,Isola J,Rantala I,Haapasalo H,Finne J

更新日期：2009-02-17 00:00:00

abstract：BACKGROUND:RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. The RASSF1 locus contains two CpG islands (A and C) and generates seven transcripts (RASSF1A-RASSF1G) by differential promoter usage and alternative...

journal_title：BMC cancer

authors： Malpeli G,Amato E,Dandrea M,Fumagalli C,Debattisti V,Boninsegna L,Pelosi G,Falconi M,Scarpa A

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...

journal_title：BMC cancer

authors： De-Masi A,Davis E,Cuming T,Chindawi N,Pesola F,Cappello C,Chambers S,Bowring J,Rosenthal AN,Sasieni P,Nathan M

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is ...

journal_title：BMC cancer

authors： Al Sarakbi W,Sasi W,Jiang WG,Roberts T,Newbold RF,Mokbel K

更新日期：2009-08-21 00:00:00

abstract：BACKGROUND:Breast metastasis from lung cancer has been reported, but not from SCLC that is transformed from lung adenocarcinoma during maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Transformation to small cell lung cancer(SCLC), although uncommonly seen, has been asso...

journal_title：BMC cancer

authors： Lin Q,Cai GP,Yang KY,Yang L,Chen CS,Li YP

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:XELOX (capecitabine + oxaliplatin) and FOLFOX 4 (5-FU + folinic acid + oxaliplatin) have shown similar improvements in survival in patients with metastatic colorectal cancer (MCRC). A US cost-minimization study found that the two regimens had similar costs from a healthcare provider perspective but XELOX had...

journal_title：BMC cancer

authors： Tse VC,Ng WT,Lee V,Lee AW,Chua DT,Chau J,McGhee SM

更新日期：2011-07-09 00:00:00

abstract：BACKGROUND:The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non-small cell lung cancer (NSCLC), especially in East Asian patients. We conducted this meta-analysis to compare their efficacy and safety in treatin...

journal_title：BMC cancer

authors： Zhang W,Wei Y,Yu D,Xu J,Peng J

更新日期：2018-08-02 00:00:00

abstract：BACKGROUND:Human Papillomavirus (HPV) genotyping has an increasingly important role in cervical cancer screening and vaccination monitoring, however, without an internationally agreed standard reference assay. The test results from the most widely used genotyping assays are read manually and hence prone to inter-observ...

journal_title：BMC cancer

authors： Ejegod DM,Rebolj M,Bonde J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophag...

journal_title：BMC cancer

authors： Bacman D,Merkel S,Croner R,Papadopoulos T,Brueckl W,Dimmler A

更新日期：2007-08-10 00:00:00

abstract：BACKGROUND:We report an extremely rare case of vaginal clear cell carcinoma, which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol (DES) exposure. CASE PRESENTATION:In this case, the patient was a Chinese woman with a history of two decades of intermittent vaginal p...

journal_title：BMC cancer

authors： Pang L,Li L,Zhu L,Lang J,Bi Y

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:While epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert a breakthrough effect, the incidence of skin disorders as a side effect has significantly reduced patients' quality of life. This study aimed to develop a treatment for inflammatory ulcers as one of the side effects of afat...

journal_title：BMC cancer

authors： Sano K,Nakadate K,Hanada K

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...

journal_title：BMC cancer

authors： Lee C,Lee J,Choi SA,Kim SK,Wang KC,Park SH,Kim SH,Lee JY,Phi JH

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid instrument measuring satisfaction among patients with breast cancer and exploring their care itiner...

journal_title：BMC cancer

authors： Defossez G,Mathoulin-Pelissier S,Ingrand I,Gasquet I,Sifer-Riviere L,Ingrand P,Salamon R,Migeot V,REPERES research network.

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and...

journal_title：BMC cancer

authors： Olsson Möller U,Rydén L,Malmström M

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence...

journal_title：BMC cancer

authors： Pfirrmann D,Tug S,Brosteanu O,Mehdorn M,Busse M,Grimminger PP,Lordick F,Glatz T,Hoeppner J,Lang H,Simon P,Gockel I

更新日期：2017-06-14 00:00:00

abstract：BACKGROUND:The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic models predict that radon could deliver a carcinogenic dose to breast tissue. Our previous work suggeste...

journal_title：BMC cancer

authors： Peng C,DuPre N,VoPham T,Heng YJ,Baker GM,Rubadue CA,Glass K,Sonawane A,Zeleznik O,Kraft P,Hankinson SE,Eliassen AH,Hart JE,Laden F,Tamimi RM

更新日期：2020-07-28 00:00:00

abstract：BACKGROUND:The facts that LPA is present at high concentration in ovarian cancer patients' ascites and it may serve as a stimulator to cell migration, implicate the role of LPA in the ovarian cancer metastasis. Since LPA mediates various biological functions through its interaction with LPA receptors, we aim to investi...

journal_title：BMC cancer

authors： Yu X,Zhang Y,Chen H

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:The expression of HER2, estrogen (ER) and progesterone (PR) receptor can change during the course of the disease in breast cancer (BC). Therefore, reassessment of these markers at the time of disease progression might help to optimize treatment decisions. In this context, characterization of circulating tumo...

journal_title：BMC cancer

authors： Aktas B,Kasimir-Bauer S,Müller V,Janni W,Fehm T,Wallwiener D,Pantel K,Tewes M,DETECT Study Group.

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. METHODS:A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall surviv...

journal_title：BMC cancer

authors： Choi JH,Choi YW,Kang SY,Jeong GS,Lee HW,Jeong SH,Park JS,Ahn MS,Sheen SS

更新日期：2020-03-02 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX). METHODS:Genomic DNA was isolated from who...

journal_title：BMC cancer

authors： Oh SY,Kwon HC,Kim SH,Lee S,Lee JH,Hwang JA,Hong SH,Graves CA,Camphausen K,Kim HJ,Lee YS

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Aboriginal status has been unreliably and incompletely recorded in health and vital registration data collections for the most populous areas of Australia, including NSW where 29% of Australian Aboriginal people reside. This paper reports an assessment of Aboriginal status recording in NSW cancer registratio...

journal_title：BMC cancer

authors： Morrell S,You H,Baker D

更新日期：2012-05-06 00:00:00