Vinflunine in routine clinical practice for the treatment of advanced or metastatic urothelial cell carcinoma - data from a prospective, multicenter experience.

abstract：BACKGROUND:The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel who had progression within 12 months while receiving an alternative inhibitor (abiraterone o...

journal_title：BMC cancer

authors： Zhang PF,Xie D,Li Q

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ≥65 years marks the potential for hypomethylating agents in elderly AML. Nevertheless the situation ...

journal_title：BMC cancer

authors： Grishina O,Schmoor C,Döhner K,Hackanson B,Lubrich B,May AM,Cieslik C,Müller MJ,Lübbert M

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fractionated radiotherapy is desired to render these hypoxic tumour regions more radiosensitive. Hypoxia a...

journal_title：BMC cancer

authors： Schilling D,Bayer C,Geurts-Moespot A,Sweep FC,Pruschy M,Mengele K,Sprague LD,Molls M

更新日期：2007-07-30 00:00:00

abstract：BACKGROUND:To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC). METHODS:We analyzed the outcome of 130 patients with BM from BC who received whole-brain radiotherapy (WBRT) (without surgery or rad...

journal_title：BMC cancer

authors： Le Scodan R,Jouanneau L,Massard C,Gutierrez M,Kirova Y,Cherel P,Gachet J,Labib A,Mouret-Fourme E

更新日期：2011-09-19 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play role in tumor dissemination and are an independent survival predictor in breast cancer (BC) patients. The aim of this study was to assess correlation between CTCs and tumor MMP1 in BC. METHOD...

journal_title：BMC cancer

authors： Cierna Z,Mego M,Janega P,Karaba M,Minarik G,Benca J,Sedlácková T,Cingelova S,Gronesova P,Manasova D,Pindak D,Sufliarsky J,Danihel L,Reuben JM,Mardiak J

更新日期：2014-06-28 00:00:00

abstract：BACKGROUND:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. Th...

journal_title：BMC cancer

authors： Ye F,Zhou C,Cheng Q,Shen J,Chen H

更新日期：2008-04-18 00:00:00

abstract：BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...

journal_title：BMC cancer

authors： Zhou P,Wang C,Hu Z,Chen W,Qi W,Li A

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction and increased physical activity may suppress hormonal, energy-sensing, and inflammatory factor...

journal_title：BMC cancer

authors： Demark-Wahnefried W,Nix JW,Hunter GR,Rais-Bahrami S,Desmond RA,Chacko B,Morrow CD,Azrad M,Frugé AD,Tsuruta Y,Ptacek T,Tully SA,Segal R,Grizzle WE

更新日期：2016-02-05 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in cancer invasion, metastasis, and chemoresistance. Additionally, EMT is partially responsible for che...

journal_title：BMC cancer

authors： Zhang Z,Zheng S,Lin Y,Sun J,Ding N,Chen J,Zhong J,Shi L,Xue M

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials, including co-administration...

journal_title：BMC cancer

authors： Li L,Huang Y,Gao Y,Shi T,Xu Y,Li H,Hyytiäinen M,Keski-Oja J,Jiang Q,Hu Y,Du Z

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Oesophageal squamous cell carcinoma (OSCC) is a major health burden in Sub-Saharan Africa, and novel chemotherapies are urgently required to combat this disease. The heat shock protein 90 (HSP90) inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) has previously been proposed as a possible candidate ...

journal_title：BMC cancer

authors： Hadley KE,Hendricks DT

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine EAC cases were available in Tissue Microarrays (TMA) format. A discovery cohort of 166 EAC cases ...

journal_title：BMC cancer

authors： Humphries MP,Craig SG,Kacprzyk R,Fisher NC,Bingham V,McQuaid S,Murray GI,McManus D,Turkington RC,James J,Salto-Tellez M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and induction of an...

journal_title：BMC cancer

authors： Weijer R,Broekgaarden M,van Golen RF,Bulle E,Nieuwenhuis E,Jongejan A,Moerland PD,van Kampen AH,van Gulik TM,Heger M

更新日期：2015-12-26 00:00:00

abstract：BACKGROUND:Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/...

journal_title：BMC cancer

authors： Sinilnikova OM,Dondon MG,Eon-Marchais S,Damiola F,Barjhoux L,Marcou M,Verny-Pierre C,Sornin V,Toulemonde L,Beauvallet J,Le Gal D,Mebirouk N,Belotti M,Caron O,Gauthier-Villars M,Coupier I,Buecher B,Lortholary A,Dugast

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological v...

journal_title：BMC cancer

authors： Jia N,Cormack FC,Xie B,Shiue Z,Najafian B,Gralow JR

更新日期：2015-07-22 00:00:00

abstract：:After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article. ...

journal_title：BMC cancer

authors： Kaveh F,Baumbusch LO,Nebdal D,Børresen-Dale AL,Lingjærde OC,Edvardsen H,Kristensen VN,Solvang HK

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Survival after diagnosis is a fundamental concern in cancer epidemiology. In resource-rich settings, ambient clinical databases, municipal data and cancer registries make survival estimation in real-world populations relatively straightforward. In resource-poor settings, given the deficiencies in a variety o...

journal_title：BMC cancer

authors： Freeman E,Semeere A,Wenger M,Bwana M,Asirwa FC,Busakhala N,Oga E,Jedy-Agba E,Kwaghe V,Iregbu K,Jaquet A,Dabis F,Yumo HA,Dusingize JC,Bangsberg D,Anastos K,Phiri S,Bohlius J,Egger M,Yiannoutsos C,Wools-Kaloustian K

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively considered a dormant variant of GC, and it infrequently progresses to advanced GC. The aim of this study ...

journal_title：BMC cancer

authors： Nakayama T,Ling ZQ,Mukaisho K,Hattori T,Sugihara H

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote cancer progression including cell survival, metastasis, and chemoresistance. The main objective of ...

journal_title：BMC cancer

authors： Oo KK,Kamolhan T,Soni A,Thongchot S,Mitrpant C,O-Charoenrat P,Thuwajit C,Thuwajit P

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism of action of ARC was further investigated by comparing in vitro and in vivo activity with other ...

journal_title：BMC cancer

authors： Stockwin LH,Yu SX,Stotler H,Hollingshead MG,Newton DL

更新日期：2009-02-20 00:00:00

abstract：BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...

journal_title：BMC cancer

authors： Inari H,Teruya N,Kishi M,Horii R,Akiyama F,Takahashi S,Ito Y,Ueno T,Iwase T,Ohno S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:An understanding of growth dynamics of tumors is important in understanding progression of cancer and designing appropriate treatment strategies. We perform a comparative study of the hyperbolastic growth models with the Weibull and Gompertz models, which are prevalently used in the field of tumor growth. M...

journal_title：BMC cancer

authors： Eby WM,Tabatabai MA,Bursac Z

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the androgen receptor (AR) and progesterone receptor (PgR) are expressed in MBC. AR activation in breas...

journal_title：BMC cancer

authors： Takuwa H,Tsuji W,Shintaku M,Yotsumoto F

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Wnt-2 plays an oncogenic role in cancer, but which Frizzled receptor(s) mediates the Wnt-2 signaling pathway in lung cancer remains unclear. We sought to (1) identify and evaluate the activation of Wnt-2 signaling through Frizzled-8 in non-small cell lung cancer, and (2) test whether a novel expression const...

journal_title：BMC cancer

authors： Bravo DT,Yang YL,Kuchenbecker K,Hung MS,Xu Z,Jablons DM,You L

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is impo...

journal_title：BMC cancer

authors： Gil-Kulik P,Dudzińska E,Radzikowska-Büchner E,Wawer J,Jojczuk M,Nogalski A,Wawer GA,Feldo M,Kocki W,Cioch M,Bogucka-Kocka A,Rahnama M,Kocki J

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:High-risk Human Papillomavirus (HPV) testing is replacing cytology in cervical cancer screening as it is more sensitive for preinvasive cervical lesions. However, the bottleneck of HPV testing is the many false positive test results (positive tests without cervical lesions). Here, we evaluated to what extent...

journal_title：BMC cancer

authors： Preisler S,Rebolj M,Ejegod DM,Lynge E,Rygaard C,Bonde J

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients...

journal_title：BMC cancer

authors： Elkiran ET,Mar N,Aygen B,Gursu F,Karaoglu A,Koca S

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specif...

journal_title：BMC cancer

authors： Xiao J,Egger ME,McMasters KM,Hao H

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age. METHODS:This single-center retrospective study included 39 infants (42 eyes) aged ≤3 months who were diagnosed with unilat...

journal_title：BMC cancer

authors： Chen Q,Zhang B,Dong Y,Mo X,Zhang L,Xia J,Zhang J,Zhang S

更新日期：2019-07-15 00:00:00