Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells.

abstract：BACKGROUND:Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-A...

journal_title：BMC cancer

authors： Martin DN,Boersma BJ,Howe TM,Goodman JE,Mechanic LE,Chanock SJ,Ambs S

更新日期：2006-10-27 00:00:00

abstract：BACKGROUND:Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs. CASE PRES...

journal_title：BMC cancer

authors： Abe M,Watanabe K,Shinozaki-Ushiku A,Ushiku T,Abe T,Fujihara Y,Amano Y,Zong L,Wang CP,Kubo E,Inaki R,Kinoshita N,Yamashita S,Takai D,Ushijima T,Nagase T,Hoshi K

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Most currently known breast cancer predisposition genes play a role in DNA repair by homologous recombination. Recent studies conducted on RAD51 paralogs, involved in the same DNA repair pathway, have identified rare germline mutations conferring breast and/or ovarian cancer predisposition in the RAD51C, RAD...

journal_title：BMC cancer

authors： Golmard L,Caux-Moncoutier V,Davy G,Al Ageeli E,Poirot B,Tirapo C,Michaux D,Barbaroux C,d'Enghien CD,Nicolas A,Castéra L,Sastre-Garau X,Stern MH,Houdayer C,Stoppa-Lyonnet D

更新日期：2013-10-19 00:00:00

abstract：BACKGROUND:In the presence of both HIV infection and cervical intraepithelial neoplasia (CIN), the risk of cancer development despite treatment may be greater. We investigated clinical predictors of persistent cytological abnormalities in women who had had a large loop excision of the transformation zone (LLETZ). METH...

journal_title：BMC cancer

authors： Adam Y,van Gelderen CJ,de Bruyn G,McIntyre JA,Turton DA,Martinson NA

更新日期：2008-07-25 00:00:00

abstract：BACKGROUND:Malignant melanoma is an aggressive type of skin cancer, and despite recent advances in treatment, the survival rate of the metastatic form remains low. Nifuroxazide analogues are drugs based on the substitution of the nitrofuran group by benzofuroxan, in view of the pharmacophore similarity of the nitro gro...

journal_title：BMC cancer

authors： Farias CF,Massaoka MH,Girola N,Azevedo RA,Ferreira AK,Jorge SD,Tavares LC,Figueiredo CR,Travassos LR

更新日期：2015-10-27 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating disease. The aim of this study was to evaluate hyperprogression in patients with malignant tumors of d...

journal_title：BMC cancer

authors： Ji Z,Peng Z,Gong J,Zhang X,Li J,Lu M,Lu Z,Shen L

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen rec...

journal_title：BMC cancer

authors： Zekas E,Prossnitz ER

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Little is known about colorectal adenoma patients' ability to adhere to behavioural interventions promoting a change in diet and physical activity. This review aimed to examine health behaviour intervention programmes promoting change in diet and/or physical activity in adenoma patients and characterise inte...

journal_title：BMC cancer

authors： McCahon D,Daley AJ,Jones J,Haslop R,Shajpal A,Taylor A,Wilson S,Dowswell G

更新日期：2015-07-07 00:00:00

abstract：BACKGOUND:Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHO...

journal_title：BMC cancer

authors： Kim MJ,Ki MS,Kim K,Shim HJ,Hwang JE,Bae WK,Chung IJ,Lee DH,Lee JK,Yoon TM,Lim SC,Chung WK,Jeong JU,Lim HS,Choi YD,Cho SH

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of thi...

journal_title：BMC cancer

authors： Fiteni F,Ray IL,Ousmen A,Isambert N,Anota A,Bonnetain F

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:The serine/threonine kinase PIM1 has been implicated as an oncogene in various human cancers including lymphomas, gastric, colorectal and prostate carcinomas. In mouse models, Pim1 is known to cooperate with c-Myc to promote tumorigenicity. However, there has been limited analysis of the tumorigenic potentia...

journal_title：BMC cancer

authors： Kim J,Roh M,Abdulkadir SA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Experimental evidence and clinical studies in breast cancer suggest that some anti-tumor therapy regimens generate stimulation of the immune system that accounts for tumor clinical responses, however, demonstration of the immunostimulatory power of these therapies on cancer patients continues to be a formida...

journal_title：BMC cancer

authors： Bernal-Estévez D,Sánchez R,Tejada RE,Parra-López C

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:BRCA1 and BRCA2 mutations are found in a proportion of families with multiple early-onset breast cancers. There are a large number of different deleterious mutations in both genes, none of which would be detectable using standard genetic association studies. Single common variants and haplotypes of common va...

journal_title：BMC cancer

authors： Turkovic L,Gurrin LC,Bahlo M,Dite GS,Southey MC,Hopper JL

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:EndoPredict (EP) is a clinically validated multianalyte gene expression test to predict distant metastasis in ER-positive, HER2-negative breast cancer treated with endocrine therapy alone. The test is based on the combined analysis of 12 genes in formalin-fixed, paraffin-embedded (FFPE) tissue by reverse tra...

journal_title：BMC cancer

authors： Kronenwett R,Bohmann K,Prinzler J,Sinn BV,Haufe F,Roth C,Averdick M,Ropers T,Windbergs C,Brase JC,Weber KE,Fisch K,Müller BM,Schmidt M,Filipits M,Dubsky P,Petry C,Dietel M,Denkert C

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clin...

journal_title：BMC cancer

authors： Charles KA,Harris BD,Haddad CR,Clarke SJ,Guminski A,Stevens M,Dodds T,Gill AJ,Back M,Veivers D,Eade T

更新日期：2016-02-18 00:00:00

abstract：BACKGROUND:Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such as liver, gut and skin. Cytokine receptor associated kinases JAK1 and JAK2 are critical for inflamm...

journal_title：BMC cancer

authors： von Bubnoff N,Ihorst G,Grishina O,Röthling N,Bertz H,Duyster J,Finke J,Zeiser R

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is ...

journal_title：BMC cancer

authors： Al Sarakbi W,Sasi W,Jiang WG,Roberts T,Newbold RF,Mokbel K

更新日期：2009-08-21 00:00:00

abstract：BACKGROUND:The aim of this study was to compare surgical treatment received by Aboriginal and non-Aboriginal people with non-small cell lung cancer (NSCLC) in New South Wales (NSW), Australia and to examine whether patient and disease characteristics are associated with any disparities found. An additional objective wa...

journal_title：BMC cancer

authors： Gibberd A,Supramaniam R,Dillon A,Armstrong BK,O'Connell DL

更新日期：2016-04-25 00:00:00

abstract：BACKGROUND:Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant type of stromal cell, in which TGF-β signaling is activated. Among the s...

journal_title：BMC cancer

authors： Horie M,Saito A,Noguchi S,Yamaguchi Y,Ohshima M,Morishita Y,Suzuki HI,Kohyama T,Nagase T

更新日期：2014-08-09 00:00:00

abstract：BACKGROUND:Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can ...

journal_title：BMC cancer

authors： Ellsworth RE,Ellsworth DL,Patney HL,Deyarmin B,Love B,Hooke JA,Shriver CD

更新日期：2008-10-14 00:00:00

abstract：BACKGROUND:Programmed cell death 1 (PD1) inhibitors have recently shown promising anti-cancer effects in a number of solid tumor types. A predictive biomarker to this class of drugs has not been clearly identified; however, overexpression of the PD1 ligand (PD-L1) has shown particular promise in lung adenocarcinoma. In...

journal_title：BMC cancer

authors： Tessier-Cloutier B,Kalloger SE,Al-Kandari M,Milne K,Gao D,Nelson BH,Renouf DJ,Sheffield BS,Schaeffer DF

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people. The aim ...

journal_title：BMC cancer

authors： Putthanachote N,Promthet S,Hurst C,Suwanrungruang K,Chopjitt P,Wiangnon S,Chen SL,Yen AM,Chen TH

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial...

journal_title：BMC cancer

authors： Ploos van Amstel FK,Prins JB,van der Graaf WT,Peters ME,Ottevanger PB

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. METHODS:We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohort) with c...

journal_title：BMC cancer

authors： Yang L,Wu Q,Xu L,Zhang W,Zhu Y,Liu H,Xu J,Gu J

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Cancer has a lot of consequences on patients' quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients' partners and their relationship, such as distress and communication difficulties. These consequences are undertreated, and interventions based on hy...

journal_title：BMC cancer

authors： Grégoire C,Faymonville ME,Vanhaudenhuyse A,Charland-Verville V,Jerusalem G,Bragard I

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer t...

journal_title：BMC cancer

authors： Wang S,Zheng Z,Chen P,Wu M

更新日期：2019-02-07 00:00:00

abstract：BACKGROUND:Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood. The aim of this study was ...

journal_title：BMC cancer

authors： Lu R,Wu C,Guo L,Liu Y,Mo W,Wang H,Ding J,Wong ET,Yu M

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:In vitro and in vivo studies have suggested that osteopontin (OPN) is associated with many types of cancers. However, no studies have reported the incidence of OPN polymorphisms and the risk of gastric cancer. The aim of this study was to investigate the association between OPN polymorphisms and gastric canc...

journal_title：BMC cancer

authors： Zhao F,Chen X,Meng T,Hao B,Zhang Z,Zhang G

更新日期：2012-10-16 00:00:00

abstract：BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple dis...

journal_title：BMC cancer

authors： Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether th...

journal_title：BMC cancer

authors： Liu C,Lu P,Lu Y,Xu H,Wang S,Chen J

更新日期：2007-10-24 00:00:00