Abstract:
BACKGROUND:Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple disaster in Fukushima, Japan, and to elucidate factors associated with post-disaster patient delay. Sociodemographic factors (age, employment status, cohabitant status and evacuation status), health characteristics, and health access- and disaster-related factors were specifically considered. METHODS:Records of symptomatic breast cancer patients diagnosed from 2005 to 2016 were retrospectively reviewed to calculate risk ratios (RRs) for patient delay in every year post-disaster compared with the pre-disaster baseline. Total and excessive patient delays were respectively defined as three months or more and twelve months or more from symptom recognition to first medical consultation. Logistic regression analysis was conducted for pre- and post-disaster patient delay in order to reveal any factors potentially associated with patient delay, and changes after the disaster. RESULTS:Two hundred nineteen breast cancer patients (122 pre-disaster and 97 post-disaster) were included. After adjustments for age, significant post-disaster increases in RRs of experiencing both total (RR: 1.66, 95% Confidence Interval (CI): 1.02-2.70, p < 0.05) and excessive patient delay (RR: 4.49, 95% CI: 1.73-11.65, p < 0.01) were observed. The RRs for total patient delay peaked in the fourth year post-disaster, and significant increases in the risk of excessive patient delay were observed in the second, fourth, and fifth years post-disaster, with more than five times the risk observed pre-disaster. A family history of any cancer was the only factor significantly associated with total patient delay post-disaster (odds ratio: 0.38, 95% CI: 0.15-0.95, p < 0.05), while there were no variables associated with delay pre-disaster. CONCLUSIONS:The triple disaster in Fukushima appears to have led to an increased risk of patient delay among breast cancer patients, and this trend has continued for five years following the disaster.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Ozaki A,Nomura S,Leppold C,Tsubokura M,Tanimoto T,Yokota T,Saji S,Sawano T,Tsukada M,Morita T,Ochi S,Kato S,Kami M,Nemoto T,Kanazawa Y,Ohira Hdoi
10.1186/s12885-017-3412-4subject
Has Abstractpub_date
2017-06-19 00:00:00pages
423issue
1issn
1471-2407pii
10.1186/s12885-017-3412-4journal_volume
17pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined. METHODS:Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We con...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3745-z
更新日期:2017-11-14 00:00:00
abstract:BACKGROUND:Cancer has a lot of consequences on patients' quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients' partners and their relationship, such as distress and communication difficulties. These consequences are undertreated, and interventions based on hy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-5046-6
更新日期:2018-11-15 00:00:00
abstract:BACKGROUND:Response-guided neoadjuvant chemotherapy (RG-NACT) with magnetic resonance imaging (MRI) is effective in treating oestrogen receptor positive/human epidermal growth factor receptor-2 negative (ER-positive/HER2-negative) breast cancer. We estimated the expected cost-effectiveness and resources required for it...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2653-y
更新日期:2016-09-05 00:00:00
abstract::It has been highlighted that in the original manuscript [1] Table S3 'An example of the predictive computational modeling process. Specific details on an annexure section of the PD-L1 pathway show the step-by-step reactions, mechanisms, and reaction equations that occur. Such reactions also occurred in all of the othe...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4200-5
更新日期:2018-04-12 00:00:00
abstract:BACKGROUND:Axillary lymph node (ALN) status is an important prognostic factor for breast cancer. We retrospectively used contrast-enhanced computed tomography (CE-CT) to evaluate the presence of ALN, metastasis based on size, shape, and contrasting effects. METHODS:Of 131 consecutive patients who underwent CE-CT follo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-730
更新日期:2014-09-30 00:00:00
abstract:BACKGROUND:The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07534-5
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Traditional beliefs of androgen's stimulating effects on the growth of prostate cancer (PCa) have been challenged in recent years. Our previous in vitro study indicated that physiological normal levels of androgens inhibited the proliferation of PCa cells. In this in vivo study, the ability of testosterone (...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3569-x
更新日期:2017-09-07 00:00:00
abstract:BACKGROUND:Data on cancers is a challenge in most developing countries. Population-based cancer registries are also not common in developing countries despite the usefulness of such registries in informing cancer prevention and control programmes. The availability of population-based data on cancers in Africa varies ac...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-362
更新日期:2014-05-23 00:00:00
abstract:BACKGROUND:Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, is linked to hereditary nonpolyposis colorectal cancer (HNPCC). Because not all MLH1 alterations result in loss of MMR function, accurate characterization of variants and their classification in terms of their effect on M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-382
更新日期:2009-10-28 00:00:00
abstract::It has been highlighted that the original manuscript [1] contains a typesetting error in the surname of Jesson Butcon. This was incorrectly captured as Jessica Butcon in the original manuscript which has since been updated. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4105-3
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based design, a novel compound, FLLL32, was generated from curcumin. FLLL32 possesses superior biochemical prop...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-112
更新日期:2011-03-28 00:00:00
abstract:BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-99
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:New Zealand and Australia have the highest incidence and mortality rates from cutaneous melanoma in the world. The predominantly fair-skinned New Zealanders and Australians both enjoy sun, tanned skin and the outdoors, and differences in these activities among generations have been important determinants of ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-372
更新日期:2013-08-06 00:00:00
abstract:BACKGROUND:Cervical cancer is the most common cancer and the leading cause of cancer death among women in Tanzania. Knowledge of and willingness to receive a cervical cancer screening are important determinants of prevention. This study aimed to describe women's awareness of cervical cancer and to explore the attitudes...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6528-x
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-4
更新日期:2008-01-13 00:00:00
abstract:BACKGROUND:Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is optimal. This study aimed to assess the outcome and failure patterns in tonsil cancer patients treated ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3571-3
更新日期:2017-08-30 00:00:00
abstract:BACKGROUND:Malignant Pleural Mesothelioma (MPM) is an aggressive tumor arising from mesothelial cells lining the pleural cavities characterized by resistance to standard therapies. Most of the molecular steps responsible for pleural transformation remain unclear; however, several growth factor signaling cascades are kn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1363-1
更新日期:2015-05-08 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This stu...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2801-4
更新日期:2016-10-18 00:00:00
abstract:BACKGROUND:Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis. The arginine-lowering agent PEGylated arginine deiminase (ADI-PEG 20) has shown efficacy as a monot...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-621
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-324
更新日期:2010-06-23 00:00:00
abstract:BACKGROUND:Given their frequency of occurrence in the United States, cancer and heart disease often coexist. For patients requiring open-heart surgery, this raises concern that the use of cardiopulmonary bypass (CPB) may cause a transient immunosuppression with the potential to promote the spread and growth of coexisti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-519
更新日期:2013-11-03 00:00:00
abstract:BACKGROUND:UroVysion fluorescence in situ hybridization (uFISH) was reported to have superior sensitivity to urine cytology. However uFISH studies are limited by varying definitions of what is considered a positive result, absence of histopathology and small sample size. The aim of our study was to better determine the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3227-3
更新日期:2017-04-07 00:00:00
abstract:BACKGROUND:High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible for treatment with poly(ADP-ribose) polymerase inhibitors (PARPi). The aim of this study was to ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-019-5535-2
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-517
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global mediator. CASE PRESENTATIONS:We report a series of four patients, diagnosed with cutaneous T-cell ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-017-3194-8
更新日期:2017-03-16 00:00:00
abstract:BACKGROUND:Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3531-y
更新日期:2017-08-11 00:00:00
abstract:BACKGROUND:The purpose of the PROLUCA study is to investigate the efficacy of preoperative and early postoperative rehabilitation in a non-hospital setting in patients with operable lung cancer with special focus on exercise. METHODS:Using a 2 x 2 factorial design with continuous effect endpoint (Maximal Oxygen Uptake...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2407-14-404
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND:The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcino...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-30
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Ongoing improvements in technique and instruments for video-assisted thoracoscopic surgery (VATS) have made minimally-invasive uniportal VATS lobectomy a reality. However, the outcomes of the procedure are still under investigation, and at present, uniportal VATS lobectomy is performed infrequently at most h...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3069-z
更新日期:2017-01-25 00:00:00
abstract:BACKGROUND:Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. METHODS:A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall surviv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6666-1
更新日期:2020-03-02 00:00:00