Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2 genes in yeast.

abstract：BACKGROUND:Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemot...

journal_title：BMC cancer

authors： Kim B,Stephen SL,Hanby AM,Horgan K,Perry SL,Richardson J,Roundhill EA,Valleley EM,Verghese ET,Williams BJ,Thorne JL,Hughes TA

更新日期：2015-09-11 00:00:00

abstract：BACKGROUND:Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of ...

journal_title：BMC cancer

authors： Folyovich A,Varga V,Várallyay G,Kozák L,Bakos M,Scheidl E,Béres-Molnár KA,Kajdácsi Z,Bereczki D

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CNB) or vacuum-assisted biopsy (VAB). A meta-analysis reported that 25.9% of invasive ductal carcinoma (IDC) cases are preoperat...

journal_title：BMC cancer

authors： Takada K,Kashiwagi S,Asano Y,Goto W,Morisaki T,Takahashi K,Fujita H,Takashima T,Tomita S,Hirakawa K,Ohira M

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. The STAT5 induced IGF-I acts as an endocrine and par...

journal_title：BMC cancer

authors： Haffner MC,Petridou B,Peyrat JP,Révillion F,Müller-Holzner E,Daxenbichler G,Marth C,Doppler W

更新日期：2007-07-25 00:00:00

abstract：BACKGROUND:Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features. METHODS:VX...

journal_title：BMC cancer

authors： Mei LJ,Yang XJ,Tang L,Hassan AH,Yonemura Y,Li Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive. METHODS:We developed a pathway based classifier approach to predict pr...

journal_title：BMC cancer

authors： Herbsleb M,Christensen OF,Thykjaer T,Wiuf C,Borre M,Orntoft TF,Dyrskjøt L

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are ...

journal_title：BMC cancer

authors： Hughes B,Yip D,Goldstein D,Waring P,Beshay V,Chong G

更新日期：2004-10-09 00:00:00

abstract：BACKGROUND:The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases...

journal_title：BMC cancer

authors： Henkens R,Delvenne P,Arafa M,Moutschen M,Zeddou M,Tautz L,Boniver J,Mustelin T,Rahmouni S

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:Platelet to Lymphocyte ratio (PLR) is thought to be associated with a worse outcome in multiple types of cancer. However, the prognostic significance of PLR has not been investigated in the prostate cancer (PCa) patients receiving hormonal therapy. The objective of this study was to determine the prognostic ...

journal_title：BMC cancer

authors： Wang Y,Xu F,Pan J,Zhu Y,Shao X,Sha J,Wang Z,Cai Y,Liu Q,Dong B,Xue W,Huang Y

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Gastric Helicobacter pylori (H. pylori) infection and colorectal polyps are more prevalent in African Americans than in the general population. We aimed to investigate whether gastric H. pylori infection is associated with colorectal polyps in African Americans. METHODS:Medical records of African Americans,...

journal_title：BMC cancer

authors： Brim H,Zahaf M,Laiyemo AO,Nouraie M,Pérez-Pérez GI,Smoot DT,Lee E,Razjouyan H,Ashktorab H

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). The use of bevacizumab to reduce angiogenesis has been associated with improved clinical outcomes. However, an urgent need for prognostic/predictive biomarkers for anti-angiogenic th...

journal_title：BMC cancer

authors： Paiva TF Jr,de Jesus VH,Marques RA,da Costa AA,de Macedo MP,Peresi PM,Damascena A,Rossi BM,Begnami MD,de Lima VC

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogran...

journal_title：BMC cancer

authors： Nielsen K,Binderup T,Langer SW,Kjaer A,Knigge P,Grøndahl V,Melchior L,Federspiel B,Knigge U

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Aquaporins (AQPs) have been recognized to promote tumor progression, invasion, and metastasis and are therefore recognized as promising targets for novel anti-cancer therapies. Potentially relevant AQPs in distinct cancer entities can be determined by a comprehensive expression analysis of the 13 human AQPs....

journal_title：BMC cancer

authors： Warth A,Muley T,Meister M,Herpel E,Pathil A,Hoffmann H,Schnabel PA,Bender C,Buness A,Schirmacher P,Kuner R

更新日期：2011-05-06 00:00:00

abstract：BACKGROUND:The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples fr...

journal_title：BMC cancer

authors： Ge M,Zhan Q,Zhang Z,Ji X,Zhou X,Huang R,Liang X

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood. METHODS:Expression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological character...

journal_title：BMC cancer

authors： An Y,Wang S,Li S,Zhang L,Wang D,Wang H,Zhu S,Zhu W,Li Y,Chen W,Ji S,Guo X

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting mutation status is insufficient to predict response. We hypothesized that prote...

journal_title：BMC cancer

authors： Carroll MJ,Parent CR,Page D,Kreeger PK

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:We report updated progression-free survival (PFS) and overall survival (OS) data from a trial that compared capecitabine plus oxaliplatin (CapeOX) versus S-1 plus oxaliplatin (SOX) for the first-line treatment of metastatic colorectal cancer. METHODS:This trial was a randomized, two-armed, non-inferiority p...

journal_title：BMC cancer

authors： Kim ST,Hong YS,Lim HY,Lee J,Kim TW,Kim KP,Kim SY,Baek JY,Kim JH,Lee KW,Chung IJ,Cho SH,Lee KH,Shin SJ,Kang HJ,Shin DB,Lee JW,Jo SJ,Park YS

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies. This study aimed to identify the key prognosis impacting genes and relevant subtypes for LUAD. ME...

journal_title：BMC cancer

authors： Lv Z,Lei T

更新日期：2020-01-27 00:00:00

abstract：BACKGROUND:Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer. METHODS:Patients with recur...

journal_title：BMC cancer

authors： Briasoulis E,Aravantinos G,Kouvatseas G,Pappas P,Biziota E,Sainis I,Makatsoris T,Varthalitis I,Xanthakis I,Vassias A,Klouvas G,Boukovinas I,Fountzilas G,Syrigos KN,Kalofonos H,Samantas E

更新日期：2013-05-29 00:00:00

abstract：BACKGROUND:Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regression following pCRT has stro...

journal_title：BMC cancer

authors： Jameson MB,Gormly K,Espinoza D,Hague W,Asghari G,Jeffery GM,Price TJ,Karapetis CS,Arendse M,Armstrong J,Childs J,Frizelle FA,Ngan S,Stevenson A,Oostendorp M,Ackland SP

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Cancer stem cell (CSC) hypothesis has not been well demonstrated by the lack of the most convincing evidence concerning a single cell capable of giving rise to a tumor. The scarcity in quantity and improper approaches for isolation and purification of CSCs have become the major obstacles for great developmen...

journal_title：BMC cancer

authors： Li HZ,Yi TB,Wu ZY

更新日期：2008-05-14 00:00:00

abstract：BACKGROUND:Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective in all patients, and the factors predicting responses among this population remain unknown. METHODS...

journal_title：BMC cancer

authors： Morita M,Tamiya M,Fujimoto D,Tamiya A,Suzuki H,Hirano K,Fukuda Y,Yokoyama T,Kominami R,Kanazu M,Uchida J,Hara S,Yamashita S,Tomioka H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely unknown. An Imaging-Genomics analysis was performed to reveal the mechanistic associations between MR...

journal_title：BMC cancer

authors： Grossmann P,Gutman DA,Dunn WD Jr,Holder CA,Aerts HJ

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This study investigated the role of hyaluronan (HA) and a potential link between the HA-CD44 pathway and...

journal_title：BMC cancer

authors： Ricciardelli C,Ween MP,Lokman NA,Tan IA,Pyragius CE,Oehler MK

更新日期：2013-10-14 00:00:00

abstract：INTRODUCTION:A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS:Intron 1 of MDM2 was PCR amplified and direct...

journal_title：BMC cancer

authors： Paulin FE,O'Neill M,McGregor G,Cassidy A,Ashfield A,Ali CW,Munro AJ,Baker L,Purdie CA,Lane DP,Thompson AM

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, water soluble and non-toxic molecule is shown to have potent anti-cancer property. METHODS:In this st...

journal_title：BMC cancer

authors： Ravi M,Tentu S,Baskar G,Rohan Prasad S,Raghavan S,Jayaprakash P,Jeyakanthan J,Rayala SK,Venkatraman G

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the oncogene HER-2 status at both the protein and the gene levels. ME...

journal_title：BMC cancer

authors： Ordás J,Millán Y,Dios R,Reymundo C,de Las Mulas JM

更新日期：2007-09-20 00:00:00

abstract：BACKGROUND:Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 mutations, and are characterized by the development of central nervous system tumors, sarcomas, adrenocortical carcinomas, and other early-onset tumors. Due to the high frequency of breast cancer in LFS/LFL families, these...

journal_title：BMC cancer

authors： Silva AG,Ewald IP,Sapienza M,Pinheiro M,Peixoto A,de Nóbrega AF,Carraro DM,Teixeira MR,Ashton-Prolla P,Achatz MI,Rosenberg C,Krepischi AC

更新日期：2012-06-12 00:00:00

abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...

journal_title：BMC cancer

authors： Ryan AV,Wilson S,Wakelam MJ,Warmington SA,Dunn JA,Hobbs RF,Martin A,Ismail T

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigration of cancer cells through e...

journal_title：BMC cancer

authors： Kouam PN,Rezniczek GA,Adamietz IA,Bühler H

更新日期：2019-10-16 00:00:00