Abstract:
BACKGROUND:The purpose of the PROLUCA study is to investigate the efficacy of preoperative and early postoperative rehabilitation in a non-hospital setting in patients with operable lung cancer with special focus on exercise. METHODS:Using a 2 x 2 factorial design with continuous effect endpoint (Maximal Oxygen Uptake (VO2peak)), 380 patients with non-small cell lung cancer (NSCLC) stage I-IIIa referred for surgical resection will be randomly assigned to one of four groups: (1) preoperative and early postoperative rehabilitation (starting two weeks after surgery); (2) preoperative and late postoperative rehabilitation (starting six weeks after surgery); (3) early postoperative rehabilitation alone; (4) today's standard care which is postoperative rehabilitation initiated six weeks after surgery. The preoperative rehabilitation program consists of an individually designed, 30-minute home-based exercise program performed daily. The postoperative rehabilitation program consists of a supervised group exercise program comprising cardiovascular and resistance training two-hour weekly for 12 weeks combined with individual counseling. The primary study endpoint is VO2peak and secondary endpoints include: Six-minute walk distance (6MWD), one-repetition-maximum (1RM), pulmonary function, patient-reported outcomes (PROs) on health-related quality of life (HRQoL), symptoms and side effects of the cancer disease and the treatment of the disease, anxiety, depression, wellbeing, lifestyle, hospitalization time, sick leave, work status, postoperative complications (up to 30 days after surgery) and survival. Endpoints will be assessed at baseline, the day before surgery, pre-intervention, post-intervention, six months after surgery and one year after surgery. DISCUSSION:The results of the PROLUCA study may potentially contribute to the identification of the optimal perioperative rehabilitation for operable lung cancer patients focusing on exercise initiated immediately after diagnosis and rehabilitation shortly after surgery. TRIAL REGISTRATION:NCT01893580.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Sommer MS,Trier K,Vibe-Petersen J,Missel M,Christensen M,Larsen KR,Langer SW,Hendriksen C,Clementsen P,Pedersen JH,Langberg Hdoi
10.1186/1471-2407-14-404subject
Has Abstractpub_date
2014-06-04 00:00:00pages
404issn
1471-2407pii
1471-2407-14-404journal_volume
14pub_type
杂志文章,随机对照试验相关文献
BMC CANCER文献大全abstract:BACKGROUND:Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral blood lymphocytes (PBLs) and glioma risk has not been investigated. METHODS:Real-time PCR was used t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-680
更新日期:2014-09-19 00:00:00
abstract:BACKGROUND:We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. METHODS:A total of 133 patients with anaplastic a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-450
更新日期:2009-12-18 00:00:00
abstract:BACKGROUND:The prevalence of patients with gastrointestinal stromal tumourgst (GIST) who fail currently available treatments imatinib and sunitinib (third-line treatment-eligible GIST) is unknown, but is expected to be below an ultra-orphan disease threshold of 2/100,000 population used in England and Wales. Our study ...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/1471-2407-14-364
更新日期:2014-05-24 00:00:00
abstract:BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. METHOD:Women diagnosed with en...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07035-5
更新日期:2020-06-20 00:00:00
abstract:BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-807
更新日期:2014-11-04 00:00:00
abstract:BACKGROUND:Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G), as well as the matched ascites for one case (OV-1946). METHODS:In addition to growth parameters,...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-152
更新日期:2008-05-28 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increased perioperative morbidity, reduced TME quality or better pathological response. Aim of this study ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6538-8
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Currently the majority of cancer patients are considered ineligible for intensive care treatment and oncologists are struggling to get their patients admitted to intensive care units. Critical care and oncology are frequently two separate worlds that communicate rarely and thus do not share novel development...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-612
更新日期:2010-11-08 00:00:00
abstract:BACKGROUND:Immune checkpoint inhibitors (ICIs) reported remarkable achievements in several solid tumours. However, in metastatic colorectal cancer (mCRC) promising results are limited to patients with deficient mismatch repair/microsatellite instability-high (dMMR/MSI-high) tumours due to their immune-enriched microenv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07169-6
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-34
更新日期:2002-12-03 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is a type of head-neck cancer with a distinguishable geographic and racial distribution worldwide. Increasing evidence supports that the accumulation of additional genetic and epigenetic abnormalities is important in driving the NPC tumorigenic process. In this study, we aim to...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2714-2
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-468
更新日期:2011-10-31 00:00:00
abstract:BACKGROUND:Although modest improvements in the survival of patients with non-small cell lung cancer (NSCLC) can be achieved with cisplatin-based chemotherapy (CT), its value is disputed in the geriatric setting. In this study, we evaluate the feasibility of vinorelbine/cisplatin CT for elderly NSCLC patients. METHODS:...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-4-69
更新日期:2004-09-29 00:00:00
abstract:BACKGROUND:The 3rd isoform of the metallothionein (MT3) gene family has been shown to be overexpressed in most ductal breast cancers. A previous study has shown that the stable transfection of MCF-7 cells with the MT3 gene inhibits cell growth. The goal of the present study was to determine the role of the unique C-ter...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3355-9
更新日期:2017-05-25 00:00:00
abstract:BACKGROUND:Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the clinical outcomes associated with either one of these combinations. METHODS:From a multi-institutiona...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2407-10-28
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is thought to be a precursor to most invasive and metastatic breast cancers. Understanding the mechanisms regulating the invasive transition of DCIS is critical in order to better understand how some types of DCIS become invasive. W...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1007-5
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health. This paper reports on trends in the geographical mortality patterns of the most frequent cancers in Spain, over a period of 2...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-535
更新日期:2014-07-24 00:00:00
abstract:BACKGROUND:Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is a benign lymphoid proliferation or malignant lymphoma in patients who have been treated with MTX. MTX withdrawal and observation for a short period should be considered in the initial management of patients who develop LPD while on MTX therapy...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2672-8
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) in patients with resectable thoracic esophageal squamo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2696-0
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated in several other cancers, its role in non-small cell lung cancer (NSCLC) is unknown. The aim of the present st...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-348
更新日期:2012-08-09 00:00:00
abstract:BACKGROUND:Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer. METHODS:Patients with recur...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-13-263
更新日期:2013-05-29 00:00:00
abstract:BACKGROUND:Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis. METHODS:The PubMed, Cochrane, and Embase da...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-020-06739-y
更新日期:2020-03-20 00:00:00
abstract:BACKGROUNDS:Cancer stem cell (CSC) research has highlighted the necessity of developing drugs targeting CSCs. We investigated a hepatocellular carcinoma (HCC) cell line that not only has CSC hierarchy but also shows phenotypic changes (population changes) upon differentiation of CSC during culture and can be used for s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1297-7
更新日期:2015-04-11 00:00:00
abstract:BACKGROUND:"Biomarker-driven targeted therapy," the practice of tailoring patients' treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 monoclonal antibody, trastuzumab, was first developed using well-characterized, diverse in vitro brea...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2232-2
更新日期:2016-03-09 00:00:00
abstract:BACKGROUND:Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncogene or a tumour suppressor, depending on the origin of the cancer. Only a few studies have reported ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-164
更新日期:2014-03-07 00:00:00
abstract:BACKGROUND:Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen in white males above the age of 40 years. Here we report a case of paraneoplastic acrokeratosis in a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1527-z
更新日期:2015-07-08 00:00:00
abstract:BACKGROUND:Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer. METHODS:A total of 301 consecutive patients (mean age, 49.8 ± 11.0 years; range, 29-86 years) with breast cancer confirmed by patho...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6578-0
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3869-1
更新日期:2017-12-18 00:00:00
abstract:OBJECTIVE:C-reactive protein (CRP) is considered a useful serum marker for patients with RCC. However, its clinical utility in advanced metastatic renal cell carcinoma (AM-RCC), particularly in deciding whether to perform nephrectomy at the onset, is not well studied. PATIENTS AND METHODS:We retrospectively evaluated ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-337
更新日期:2012-08-02 00:00:00
abstract:BACKGROUND:Weekly docetaxel has occasionally been used in the neoadjuvant to downstage breast cancer to reduce toxicity and possibly enhance quality of life. However, no studies have compared the standard three weekly regimen to the weekly regimen in terms of quality of life. The primary aim of our study was to compare...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1471-2407-11-179
更新日期:2011-05-18 00:00:00