Abstract：
BACKGROUND:Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how this relationship is influenced by menopausal status. METHODS:Body fat percentage was measured 1 day before and 6 months after surgery in 131 women with stages 0-III breast cancer. Disease outcomes (metastasis and death) were assessed by chart review and telephone contact 7 to 8 years after diagnosis. These data were analyzed by multivariate Cox proportional hazard model analysis. RESULTS:The percentage of women with over 5% gain in body-fat was 56% for premenopausal and 42% for postmenopausal. Rates of distant metastasis and all-cause mortality were 17.6 and 9.9%, respectively over the follow-up period. Distant metastases were predicted in postmenopausal but not premenopausal women with breast cancer by increased body fat percentage (HR = 1.3, p = 0.035), after controlling other potential covariates, including disease severity, estrogen receptor expression, progesterone receptors expression, age, and exercise habit before diagnosis. Survival was not significantly associated with body-fat percentage gains. CONCLUSIONS:Our results suggest that increased body fat percentage 6 months after breast surgery is an important predictor of distant metastasis in postmenopausal Taiwanese women with breast cancer. Clinicians may need to measure patients' body fat periodically. Our findings should be validated in studies with a longer follow-up time.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Liu LN,Lin YC,Miaskowski C,Chen SC,Chen MLdoi
10.1186/s12885-017-3869-1subject
Has Abstractpub_date
2017-12-18 00:00:00pages
863issue
1issn
1471-2407pii
10.1186/s12885-017-3869-1journal_volume
17pub_type
杂志文章相关文献
BMC CANCER文献大全abstract：BACKGROUND:The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection in the current clinical practice. METHODS:Stage I-II NSCLC patients (surgery 55 patients, SBRT 29 patients, median age 68)...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-3986-5
更新日期：2018-01-15 00:00:00
abstract：BACKGROUND:Cancer services are inaccessible in many low-income countries, and few published examples describe oncology programs within the public sector. In 2011, the Rwanda Ministry of Health (RMOH) established Butaro Cancer Center of Excellence (BCCOE) to expand cancer services nationally. In hopes of informing cance...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2256-7
更新日期：2016-03-18 00:00:00
abstract：BACKGROUND:The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-147
更新日期：2008-05-27 00:00:00
abstract：BACKGROUND:Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield higher BED, shorten the total treatmen...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2314-1
更新日期：2016-04-23 00:00:00
abstract：BACKGROUND:Abundant research suggested that the cancer cells avoid destruction by the immune system through down-regulation or mutation of death receptors. Therefore, it is very important that finding the agents that increase the death receptors of cancer cells. In this study, we demonstrated that the snake venom toxin...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-12-228
更新日期：2012-06-08 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-6638-5
更新日期：2020-02-28 00:00:00
abstract：BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-6-249
更新日期：2006-10-20 00:00:00
abstract：BACKGROUND:Growing evidence has indicated that some inflammatory markers, including lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI), can be used as indicators in the prognosis of colorectal cancer (CRC). However, there ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3752-0
更新日期：2017-11-10 00:00:00
abstract：BACKGROUND:Recent reports indicate the existence of breast cancer cells expressing very high levels of the Arylhydrocarbon receptor (AhR), a ubiquitous intracellular receptor best known for mediating toxic action of dioxin and related pollutants. Positive correlation between the degree of AhR overexpression and states ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-9-234
更新日期：2009-07-15 00:00:00
abstract：BACKGROUND:The survival following transarterial chemoembolization (TACE) alone is still low in unresectable hepatocellular carcinoma (HCC) with almost patients developing disease progression after treatment. There is need to investigate additional therapeutic options that would intensify the initial response to TACE. T...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2894-9
更新日期：2016-11-03 00:00:00
abstract：BACKGROUND:Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic approaches is imperatively needed for this disease. We have recently shown that activation of AMP-acti...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-327
更新日期：2013-07-03 00:00:00
abstract：BACKGROUND:The number of Nigerian men presenting with benign prostatic hyperplasia is on the rise because of increase awareness about the ailment. With the renewed effort by the national health insurance scheme to cover the informal sector, it becomes imperative to determine the cost implication for managing Benign Pro...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-016-2431-x
更新日期：2016-07-07 00:00:00
abstract：BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic si...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07121-8
更新日期：2020-07-06 00:00:00
abstract：BACKGROUND:The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005. METHODS:Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS wa...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-10-622
更新日期：2010-11-10 00:00:00
abstract：BACKGROUND:Patients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance. METHODS:Tumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1029-z
更新日期：2015-02-18 00:00:00
abstract：BACKGROUND:From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-1317-7
更新日期：2015-04-23 00:00:00
abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4965-6
更新日期：2018-11-12 00:00:00
abstract：BACKGROUND:Pelvic inflammatory disease (PID) is characterized by infection and inflammation of the upper genital tract in women and is associated with health sequelae. We used a nationwide population-based retrospective cohort study to explore the relationship between PID and the subsequent development of gynecological...
journal_title：BMC cancer
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12885-016-2857-1
更新日期：2016-11-03 00:00:00
abstract：BACKGROUND:Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neoplasia in symptomatic patients in fast-track programs. METHODS:All patients referred for fast-track...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-019-5926-4
更新日期：2019-07-25 00:00:00
abstract：BACKGROUND:Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpose of this study was to elucidate clinical and imaging features of MS based upon a multicenter patie...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究
doi：10.1186/s12885-019-6357-y
更新日期：2019-11-27 00:00:00
abstract：BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thy...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3120-0
更新日期：2017-02-16 00:00:00
abstract：BACKGROUND:Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America. METHODS:Eleven LS hereditary cancer registrie...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-017-3599-4
更新日期：2017-09-05 00:00:00
abstract：BACKGROUND:Hypoxia is an important factor that contributes to tumour aggressiveness and correlates with poor prognosis and resistance to conventional therapy. Therefore, identifying hypoxic environments within tumours is extremely useful for understanding cancer biology and developing novel therapeutic strategies. Seve...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-019-5727-9
更新日期：2019-05-29 00:00:00
abstract：BACKGROUND:Aberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been associated with resistance to HER targeted therapy. In this study, we investigated the effect of simultaneous targeting of IGF-IR and HER (erbB) family, with NVP-AEW541 and afatinib, on proliferati...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-13-41
更新日期：2013-01-31 00:00:00
abstract：INTRODUCTION:A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS:Intron 1 of MDM2 was PCR amplified and direct...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-8-281
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). METHODS:A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-018-4822-7
更新日期：2018-09-21 00:00:00
abstract：BACKGROUND:Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second ...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-015-2033-z
更新日期：2015-12-23 00:00:00
abstract：BACKGROUND:Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship between the severity of potentially remediable cancer-associated circadian disruption and quality of l...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/1471-2407-11-193
更新日期：2011-05-23 00:00:00
abstract：BACKGROUND:A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the research group, 80% of the patients with breast cancer reported a high level of stress symptoms close t...
journal_title：BMC cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1471-2407-12-167
更新日期：2012-05-04 00:00:00
abstract：BACKGROUND:This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. METHODS:In this retrospective case series, intravitreal chemotherapy-assisted en...
journal_title：BMC cancer
pub_type： 杂志文章
doi：10.1186/s12885-020-07314-1
更新日期：2020-08-26 00:00:00
