Abstract:
BACKGROUND:Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thyroid microcarcinomas. METHODS:Amongst 1459 sequential patients undergoing thyroid surgery at a single center, 132 (9%) cases were diagnosed with PTM. We performed a retrospective analysis of these cases using Fisher's Exact Test. The statistical significance was set at p < 0.05 a priori. RESULTS:A relationship between large PTM and high risk features was observed only for extra-thyroidal cancer extension (ETE). Six of 57 large PTM (11%) but none of the 75 small PTM had ETE (p < 0.01). Lymph node metastases were associated with both small PTM (5/9 cases) and large PTM (4/9 cases). A distant metastases was diagnosed in association with a small PTM. CONCLUSIONS:For PTM, neither small cancer size, nor the absence of high-risk features, excluded the possibility of synchronous lymph node metastases.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Bradley NL,Wiseman SMdoi
10.1186/s12885-017-3120-0subject
Has Abstractpub_date
2017-02-16 00:00:00pages
142issue
1issn
1471-2407pii
10.1186/s12885-017-3120-0journal_volume
17pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA (protein) Napsin A was described to promote resistance to cisplatin by degradation of the tumor sup...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-524
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel who had progression within 12 months while receiving an alternative inhibitor (abiraterone o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07754-9
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour ...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究
doi:10.1186/s12885-016-2345-7
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadju...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07766-5
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastrointestinal (GI) NETs with 177Lu-Dotatate resulted in a significant improvement in progression-free su...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07710-7
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:CD26/dipeptidyl peptidase IV (DPPIV) is a multifunctional membrane protein with a key role in T-cell biology and also serves as a marker of aggressive cancers, including T-cell malignancies. METHODS:Versican expression was measured by real-time RT-PCR and Western blots. Gene silencing of versican in parenta...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-517
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based compara...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-98
更新日期:2008-04-11 00:00:00
abstract:BACKGROUND:The care itinerary for cancer involves difficulties that occur in several different areas, whether in the diagnostic procedures, in surgery, or in adjuvant treatment. The aim of this work was to obtain a valid instrument measuring satisfaction among patients with breast cancer and exploring their care itiner...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-129
更新日期:2007-07-16 00:00:00
abstract:BACKGROUND:Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/F...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-551
更新日期:2014-07-30 00:00:00
abstract:BACKGROUND:In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supportive care, and human resources, make compliance with protocol-driven treatment challenging in low- and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6611-3
更新日期:2020-03-29 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators ("writer," "eraser," and "reader" proteins), which are associated with cancer occurrence and development. Th...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-6638-5
更新日期:2020-02-28 00:00:00
abstract:INTRODUCTION:A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS:Intron 1 of MDM2 was PCR amplified and direct...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-281
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dysfunction after hepatic arterial infusion chemotherapy (HAIC) successfully treated by liver resectio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2749-4
更新日期:2016-09-01 00:00:00
abstract::... ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-5669-2
更新日期:2019-05-13 00:00:00
abstract::It has been highlighted that the original manuscript [1] contains a typesetting error in the surname of Jesson Butcon. This was incorrectly captured as Jessica Butcon in the original manuscript which has since been updated. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4105-3
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4914-4
更新日期:2018-10-19 00:00:00
abstract:BACKGROUND:Previous studies on bladder cancer have shown nodal involvement to be an independent indicator of prognosis and survival. This study aimed at developing an objective method for detection of nodal metastasis from molecular profiles of primary urothelial carcinoma tissues. METHODS:The study included primary b...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-159
更新日期:2006-06-16 00:00:00
abstract:BACKGROUND:The discovery of a solitary pulmonary nodule (SPN) on a chest imaging exam is of major clinical concern. However, the incidence rates of SPNs in a general population have not been estimated. The objective of this study was to provide incidence estimates of SPNs in a general population in 5 northeastern regio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-3029-z
更新日期:2017-01-11 00:00:00
abstract:BACKGROUND:MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. To investigate the progn...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2869-x
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:Salivary gland cancer (SGC) is one of the common malignancies of the head and neck area. It develops in the minor and major salivary glands and sometimes metastasizes to other organs, particularly to the lungs. Inhibitors of differentiation (Id) proteins are negative regulators of basic helix-loop-helix tran...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-141
更新日期:2013-03-22 00:00:00
abstract:BACKGROUND:No scientific consensus has been reached on whether active tobacco smoking causes breast cancer. We examine the association between active smoking and breast cancer risk in Denmark, which has some of the highest smoking and breast cancer rates in women worldwide. METHODS:We used the data from a nationwide D...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3546-4
更新日期:2017-08-22 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, ...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/s12885-017-3371-9
更新日期:2017-06-02 00:00:00
abstract:BACKGROUND:The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encouraging consistent adoption of sun-protective behaviours, incidence rates are not decreasing. There i...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1471-2407-14-162
更新日期:2014-03-07 00:00:00
abstract:BACKGROUND:There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-219
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:High levels of blood glucose are thought to be associated with colorectal cancer (CRC) and hyperinsulinemia, an interstage in the development of CRC. The purpose of this study was to examine associations between incident CRC and blood glucose; plasma insulin; and the homeostasis model assessment for insulin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3874-4
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Methylation of promoter region is the major mechanism affecting gene expression in tumors. Recent methylome studies of brain tumors revealed a list of new epigenetically modified genes. Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-218
更新日期:2012-06-06 00:00:00
abstract:BACKGROUND:Thymidylate synthase (TS) and Topoisomerase I (Topo I) are significant biomarkers in colorectal cancer (CRC). We aimed to study the expression of TS and Topo I in patients with resected CRC who received adjuvant chemotherapy and correlated it with clinical outcome. METHODS:All patients diagnosed with CRC be...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-339
更新日期:2009-09-24 00:00:00
abstract:BACKGROUND:In a phase I study of angiotensin-(1-7) [Ang-(1-7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1-7) induced changes in biomarkers according to cancer type and investigates mechanisms of action engaged in vitro. MET...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-404
更新日期:2012-09-11 00:00:00
abstract:BACKGROUND:About 85% of breast cancer patients attending Komfo Anokye Teaching Hospital (KATH), Ghana, present with stage III/IV disease. In spite of great investments into the early diagnosis and management of breast cancer, late presentation persists and poses a barrier to realising the possible benefits of the gains...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07520-x
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-27
更新日期:2007-02-02 00:00:00