Reverse translation of phase I biomarker findings links the activity of angiotensin-(1-7) to repression of hypoxia inducible factor-1α in vascular sarcomas.

abstract：BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic si...

journal_title：BMC cancer

authors： Kloker LD,Berchtold S,Smirnow I,Beil J,Krieg A,Sipos B,Lauer UM

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this disease. However, the mechanism of miRNA-induced mRNA cleavage remains to be investigated. METHOD:In...

journal_title：BMC cancer

authors： Zhou F,Tang D,Xu Y,He H,Wu Y,Lin L,Dong J,Tan W,Dai Y

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:Stimulation of vascular endothelial growth factor (VEGF) has been observed following transarterial chemoembolization (TACE) in hepatocellular cancer (HCC) and may contribute to tumor regrowth. This pilot study examined whether intravenous (IV) bevacizumab, a monoclonal antibody against VEGF, could inhibit ne...

journal_title：BMC cancer

authors： Britten CD,Gomes AS,Wainberg ZA,Elashoff D,Amado R,Xin Y,Busuttil RW,Slamon DJ,Finn RS

更新日期：2012-01-14 00:00:00

abstract：BACKGROUND:As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of cancer-related pain in the outpatient setting. METHODS:We conducted a prospective study to compare rein...

journal_title：BMC cancer

authors： Peng Z,Li L,Chen Y,Feng Z,Fang X

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relationship between the margin-negative (R0) resection rate and findings indicating peripancreatic vascular...

journal_title：BMC cancer

authors： Yasuta S,Kobayashi T,Aizawa H,Takahashi S,Ikeda M,Konishi M,Kojima M,Kuno H,Uesaka K,Morinaga S,Miyamoto A,Toyama H,Takakura N,Sugimachi K,Takayama W

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the an...

journal_title：BMC cancer

authors： Yue T,Zheng X,Dou Y,Zheng X,Sun R,Tian Z,Wei H

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:To investigate whether MRI findings, including texture analysis, can differentiate KRAS mutation status in rectal cancer. METHODS:Totally, 158 patients with pathologically proved rectal cancers and preoperative pelvic MRI examinations were enrolled. Patients were stratified into two groups: KRAS wild-type g...

journal_title：BMC cancer

authors： Xu Y,Xu Q,Ma Y,Duan J,Zhang H,Liu T,Li L,Sun H,Shi K,Xie S,Wang W

更新日期：2019-11-14 00:00:00

abstract：BACKGROUND:Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. METHODS:Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and B...

journal_title：BMC cancer

authors： Zhou Y,Yau C,Gray JW,Chew K,Dairkee SH,Moore DH,Eppenberger U,Eppenberger-Castori S,Benz CC

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. The difficulties in obtaining biopsies at progression make it challenging to investigate the appeara...

journal_title：BMC cancer

authors： Demuth C,Madsen AT,Weber B,Wu L,Meldgaard P,Sorensen BS

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects rel...

journal_title：BMC cancer

authors： Dimou A,Barron G,Merrick DT,Kolfenbach J,Doebele RC

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 an...

journal_title：BMC cancer

authors： Klenke S,Akdeli N,Stelmach P,Heukamp L,Schulte JH,Bachmann HS

更新日期：2019-03-18 00:00:00

abstract：BACKGROUND:Metastatic progression due to development or enrichment of therapy-resistant tumor cells is eventually lethal. Molecular characterization of such chemotherapy resistant tumor cell clones may identify markers responsible for malignant progression and potential targets for new treatment. Here, in a case of sta...

journal_title：BMC cancer

authors： Hjortland GO,Meza-Zepeda LA,Beiske K,Ree AH,Tveito S,Hoifodt H,Bohler PJ,Hole KH,Myklebost O,Fodstad O,Smeland S,Hovig E

更新日期：2011-10-20 00:00:00

abstract：BACKGROUND:Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen rec...

journal_title：BMC cancer

authors： Zekas E,Prossnitz ER

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Hyaluronan (HA) an important component of the extracellular matrix, has been linked to tumor progression and drug resistance in several malignancies. However, limited data is available for ovarian cancer. This study investigated the role of hyaluronan (HA) and a potential link between the HA-CD44 pathway and...

journal_title：BMC cancer

authors： Ricciardelli C,Ween MP,Lokman NA,Tan IA,Pyragius CE,Oehler MK

更新日期：2013-10-14 00:00:00

abstract：BACKGROUND:For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer. METHODS:Using population-based data from the Korea Central Cancer Re...

journal_title：BMC cancer

authors： Kwon WA,Joung JY,Lim J,Oh CM,Jung KW,Kim SH,Seo HK,Park WS,Chung J,Lee KH,Won YJ

更新日期：2018-05-31 00:00:00

abstract：BACKGROUND:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune system. However, the roles and clinical relevance of the collective or individual NADPH oxidase (NO...

journal_title：BMC cancer

authors： Cho SY,Kim S,Son MJ,Kim G,Singh P,Kim HN,Choi HG,Yoo HJ,Ko YB,Lee BS,Eun HS

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the prognostic and predictive significance of tumor length in patients with esophageal squamous cell carcinoma undergoing radical resection. METHODS:Tumor length and other clinicopathological variables were retrospectively evaluated in 1435 patients with squamo...

journal_title：BMC cancer

authors： Wu J,Chen QX

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005. METHODS:Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS wa...

journal_title：BMC cancer

authors： Hamidou Z,Causeret S,Dabakuyo TS,Gentil J,Arnould L,Roignot P,Altwegg T,Poillot ML,Bonnetain F,Arveux P

更新日期：2010-11-10 00:00:00

abstract：BACKGROUND:Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its...

journal_title：BMC cancer

authors： Zhao J,Hu C,Wang C,Yu W,Guo Y,Shi M,Shui Y,Wei Q

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2 (COX-2) has been reported to be involved in the critical steps in carcinogenesis. However, possible...

journal_title：BMC cancer

authors： Zhang XH,Huang DP,Guo GL,Chen GR,Zhang HX,Wan L,Chen SY

更新日期：2008-01-13 00:00:00

abstract：BACKGROUND:The facts that LPA is present at high concentration in ovarian cancer patients' ascites and it may serve as a stimulator to cell migration, implicate the role of LPA in the ovarian cancer metastasis. Since LPA mediates various biological functions through its interaction with LPA receptors, we aim to investi...

journal_title：BMC cancer

authors： Yu X,Zhang Y,Chen H

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:The mammalian FOXO (forkhead box, O subclass) proteins are a family of pleiotropic transcription factors involved in the regulation of a broad range of cellular processes critical for survival. Despite the essential and diverse roles of the FOXO family members in human cells and their involvement in tumor pa...

journal_title：BMC cancer

authors： Dallas PB,Egli S,Terry PA,Kees UR

更新日期：2007-04-19 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intens...

journal_title：BMC cancer

authors： Siva S,Callahan J,Kron T,Martin OA,MacManus MP,Ball DL,Hicks RJ,Hofman MS

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:The standard therapy regimen of conventional osteosarcoma includes neoadjuvant chemotherapy followed by surgical resection and postoperative chemotherapy. The percentage of necrotic tissue following induction chemotherapy is assessed by using the Huvos grading system, which classifies patients as "poor respo...

journal_title：BMC cancer

authors： Salas S,Jiguet-Jiglaire C,Campion L,Bartoli C,Frassineti F,Deville JL,Maues De Paula A,Forest F,Jézéquel P,Gentet JC,Bouvier C

更新日期：2014-08-20 00:00:00

abstract：BACKGROUND:Plenty of studies have demonstrated the prognostic value of various inflammation-based indexes in cancer. This study was designed to investigate the prognostic value of the C-reactive protein/albumin (CRP/Alb) ratio in esophageal squamous cell carcinoma. METHODS:A retrospective study of 423 cases with newly...

journal_title：BMC cancer

authors： Wei XL,Wang FH,Zhang DS,Qiu MZ,Ren C,Jin Y,Zhou YX,Wang DS,He MM,Bai L,Wang F,Luo HY,Li YH,Xu RH

更新日期：2015-05-02 00:00:00

abstract：BACKGROUND:Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectomy (RAE). Previous studies had demonstrated the better short-term outcomes in MIE or RAE when compare...

journal_title：BMC cancer

authors： Yang Y,Zhang X,Li B,Li Z,Sun Y,Mao T,Hua R,Yang Y,Guo X,He Y,Li H,Chen H,Tan L

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tumour-associated stroma. Studies in animal models have shown influence of tumour-associated macrophag...

journal_title：BMC cancer

authors： Bacman D,Merkel S,Croner R,Papadopoulos T,Brueckl W,Dimmler A

更新日期：2007-08-10 00:00:00

abstract：BACKGROUND:Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of recurrent glioblastoma, too. In both cases, adjuvant treatment, mostly using temozolomide, can improve...

journal_title：BMC cancer

authors： Straube C,Scherb H,Gempt J,Kirschke J,Zimmer C,Schmidt-Graf F,Meyer B,Combs SE

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncogene or a tumour suppressor, depending on the origin of the cancer. Only a few studies have reported ...

journal_title：BMC cancer

authors： Jeong D,Heo S,Sung Ahn T,Lee S,Park S,Kim H,Park D,Byung Bae S,Lee SS,Soo Lee M,Kim CJ,Jun Baek M

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY ...

journal_title：BMC cancer

authors： Domínguez-Sánchez MS,Sáez C,Japón MA,Aguilera A,Luna R

更新日期：2011-02-17 00:00:00